Search results for " Rene"
showing 10 items of 263 documents
Cilium induction triggers differentiation of glioma stem cells.
2020
Glioblastoma multiforme (GBM) possesses glioma stem cells (GSCs) that promote self-renewal, tumor propagation, and relapse. Understanding the mechanisms of GSCs self-renewal can offer targeted therapeutic interventions. However, insufficient knowledge of GSCs' fundamental biology is a significant bottleneck hindering these efforts. Here, we show that patient-derived GSCs recruit elevated levels of proteins that ensure the temporal cilium disassembly, leading to suppressed ciliogenesis. Depleting the cilia disassembly complex components is sufficient to induce ciliogenesis in a subset of GSCs via relocating platelet-derived growth factor receptor-alpha (PDGFR-α) to a newly induced cilium. Im…
Entrepreneurship in Rural Areas and Sustainable Development - to What Extent Self-Government Activities Support them. A Case Study of Opole Voivodesh…
2020
Entrepreneurship acts as a catalyst for resolving many economic and social issues. It is often seen as the key factor in driving employment rates in rural areas, particularly among young people. It significantly impacts the overall development of the region, including the quality of life. More job opportunities help create employment for a number of people within their own social system. More specifically, it encourages young and well-educated people to stay in village areas which otherwise become increasingly depopulated. This brings us to a problem; to overcome the existing challenges, rural areas must not only drive the development but also ensure its sustainability. Sustainable rural de…
Promoting the Flexibility of Thermal Prosumers Equipped with Heat Pumps to Support Power Grid Management
2023
The increasing share of renewable energy sources in energy systems will lead to unpredictable moments of surplus/deficit in energy production. To address this issue, users with heat pumps can provide support to power grid operators through flexible unit operation achieved via Demand Response programs. For buildings connected to low-temperature heating networks with ensured third-party access, further room for flexibility can be explored by investigating the production of surplus heat that can be sold to the network. A key aspect lies in the identification of the energy pricing options that could encourage such flexible operation of a heat pump by “thermal prosumers”. To this aim…
The Fluid City Paradigm : Waterfront Regeneration as an Urban Renewal Strategy
2016
This book presents a new paradigm of knowledge and action with respect to urban waterfronts and the “fluid city paradigm,” explaining its methodological framework and describing an integrated and creative planning approach in which waterfront regeneration is pursued as a key urban-renewal strategy. It focuses especially on the WATERFRONT project (“Water And Territorial policiEs for integRation oF multisectoRial develOpmeNT”), which was funded jointly by Italy and Malta with the goal of developing common guidelines, strategies, and operational tools for the planning of coastal areas, based on cross-border exchange of experiences. In the described approach, the waterfront is recognized as hav…
Integral Extraction of Opuntia ficus-indica Peel Bioproducts via Microwave-Assisted Hydrodiffusion and Hydrodistillation
2019
The microwave-assisted hydrodiffusion extraction process affords high quality pectin and betanin from the peel of red and green Opuntia ficus-indica fruits under mild conditions. An aqueous mixture of valued bioproducts is readily obtained from the fruit peel cell water itself, without any water addition. The integral extract can be used as such to formulate nutraceutical beverages and products or, upon straightforward separation, to isolate pectin and betanin devoid of chemical contaminants suitable as ingredients for products ranging from food and beverage to cosmetic and pharmaceutical sectors. Betanin shows exceptional stability thanks to the high amounts of antioxidant polyphenols in t…
Power dispatching of active generators using droop control in grid connected micro-grid
2014
Masteroppgave i fornybar energi ENE 500 Universitetet i Agder 2014 Renewable energy promises a green energy future for the world. However, many technical problems still have to be solved. Almost all renewable energy sources require power electronic converters for power processing and therefore inverter control systems and power dispatching strategies are significant in renewable energy applications. The existing electricity grid architecture is based on centralized power generations while most renewable power generations are distributed and connected to lower or medium voltage networks. Some of important renewable energy resources such as solar and wind power are intermittent in nature. Thi…
Estimating finite mixtures of semi-Markov chains: an application to the segmentation of temporal sensory data
2019
Summary In food science, it is of great interest to obtain information about the temporal perception of aliments to create new products, to modify existing products or more generally to understand the mechanisms of perception. Temporal dominance of sensations is a technique to measure temporal perception which consists in choosing sequentially attributes describing a food product over tasting. This work introduces new statistical models based on finite mixtures of semi-Markov chains to describe data collected with the temporal dominance of sensations protocol, allowing different temporal perceptions for a same product within a population. The identifiability of the parameters of such mixtur…