Search results for " Rest"
showing 10 items of 2211 documents
Aspetti tecnologici per il riuso: contributi al dibattito
2016
Qui il taglio della trattazione sul riuso della Centrale Enel Tifeo è legato alle questioni tecnologiche sia pure in un’accezione ampia che declina sia le tecniche ambientali che le tecnologie connesse agli edifici e alle costruzioni. Una lettura disciplinare, certamente parziale e limitata, che non vuole mancare però di individuare fattori comuni e temi di dibattito di più ampio respiro. Si tenta questa analisi con una struttura di tre paragrafi, parzialmente correlati a scale di problemi: il contesto e il lotto, quale area di dominio; l’involucro, soprattutto considerato per l’edificio dei turbo-alternatori; l’ambiente indoor e gli spazi interni in edifici dalla spazialità estremamente pa…
REHABILITATION, ENHANCEMENT AND PROMOTION OF ART NOUVEAU BUILDINGS
2016
Since ancient times every era has produced a particular architectural heritage with different materials and with the use of different construction. This study aims to make a contribution in terms of knowledge and the architectural heritage of the 20th century, recovery, and in particular those representing the Sicilian architecture known as Liberty architecture. The study explores the relationship between architecture, materials, construction techniques and the building restoration and enhancement problems. The main purpose of this research is on the one hand the analysis and technological knowledge of the architectural heritage and the other to study the types of …
MHC class II-expressing hepatocytes function as antigen-presenting cells and activate specific CD4 T lymphocyutes.
2003
The ability to activate CD4 T cells is restricted to antigen-presenting cells that express major histocompatibility complex (MHC) class II molecules. Parenchymal cells normally do not express MHC class II molecules; however, in clinical hepatitis, viral or autoimmune, hepatocytes often exhibit aberrant MHC class II expression. It is not known whether MHC class II-expressing hepatocytes can function as antigen-presenting cells, but it has been suggested that aberrant MHC class II expression by parenchymal cells may cause autoimmune disease. Therefore, we generated transgenic mice that specifically overexpress class II transactivator molecules in hepatocytes. Hepatocytes from these mice exhib…
Defective T helper response of hepatocyte-stimulated CD4 T cells impairs antiviral CD8 response and viral clearance.
2007
Background & Aims: In hepatitis, hepatocytes gain the ability to express major histocompatibility complex (MHC) class II molecules and to present antigen to CD4 T cells. Here, we investigated whether MHC class II-expressing hepatocytes influence in vitro the differentiation of CD4 T cells and in vivo the T-cell response to and control of viral infection. Methods: Class II transactivator-transgenic hepatocytes that constitutively express MHC class II molecules were used to stimulate CD4 T cells in vitro, and the effector response type of the stimulated CD4 T cells was determined. The in vivo relevance of the obtained findings was confirmed by infecting nontransgenic or class II transactivato…
Increased antigen presentation efficiency by coupling antigens to MHC class I trafficking signals.
2007
Abstract Genetic modification of vaccines by linking the Ag to lysosomal or endosomal targeting signals has been used to route Ags into MHC class II processing compartments for improvement of CD4+ T cell responses. We report in this study that combining an N-terminal leader peptide with an MHC class I trafficking signal (MITD) attached to the C terminus of the Ag strongly improves the presentation of MHC class I and class II epitopes in human and murine dendritic cells (DCs). Such chimeric fusion proteins display a maturation state-dependent subcellular distribution pattern in immature and mature DCs, mimicking the dynamic trafficking properties of MHC molecules. T cell response analysis in…
Differential expression of alternative H2-M isoforms in B cells, dendritic cells and macrophages by proinflammatory cytokines.
1999
Major histocompatibility (MHC) class II heterodimers bind peptides generated by degradation of endocytosed antigens and display them on the surface of antigen presenting cells (APCs) for recognition by CD4+ T cells. Efficient loading of MHC class II molecules with peptides is catalyzed by the MHC class II-like molecule H2-M. The coordinate regulation of MHC class II and H2-M expression is a prerequisite for efficient MHC class II/peptide assembly in APCs determining both the generation of the T cell repertoire in the thymus and cellular immune responses in the periphery. Here we show that expression of H2-M and MHC class II genes is coordinately and cell type-specific regulated in splenic B…
H2-M, a facilitator of MHC class II peptide loading, and its negative modulator H2-O are differentially expressed in response to proinflammatory cyto…
2000
H2-M is a major histocompatibility complex (MHC) class II-like molecule that catalyzes peptide binding to MHC class II molecules. Recently, the H2-O heterodimer, encoded by H2-Oa and H2-Ob in the MHC class II region, has been shown to be physically associated with H2-M in B cells and to downregulate H2-M function. Examination of H2-O expression in freshly isolated mouse organs revealed that H2-Oa- and H2-Ob-specific transcripts are present in both lymphoid and nonlymphoid tissues. To evaluate the gene regulation and functional impact of H2-O on antigen presentation, we examined the effects on MHCII, invariant chain (Ii), H2-M, and H2-O gene expression of interleukin (IL)-4, IL-10, and inter…
Multiple levels of MHC class I down-regulation by ras oncogenes.
1996
A number of tumours and oncogene transformed cells displayed reduced MHC class I surface expression which seemed to enable their escape from immune surveillance. To test whether oncogenic activation is directly involved in suppressing MHC class I expression, a model of inducible oncogene expression was chosen. Mouse fibroblasts transfected with different oncogenes expressed under the control of the dexamethasone-inducible MMTV promoter were analysed in the presence and absence of hormone for the mRNA and protein expression of MHC class I molecules as well as the respective oncogenes. Immunofluorescence analyses demonstrated an inverse association of MHC class I and oncogene expression after…
Que reste-t-il de l'abus dans le non-renouvellement du contrat ?
2014
International audience
RUINS PRESERVATION, TRANSFORMATION IN THEIR USE: HOUSING PROJECTS IN THE OLD TOWN CENTRE OF PALERMO
2011
Il centro storico di Palermo, uno dei più grandi del Mediterraneo, mantiene la sua densa stratificazione storica nonostante che le distruzioni belliche del 1943 e i lunghi decenni di abbandono successivo ne abbiano sfigurato il patrimonio monumentale. Tuttavia sono stati realizzati, e vengono analizzati, alcuni casi di riutilizzazione in senso culturale e a valenza pubblica, di complessi monumentali che, utilizzando linguaggi contemporanei, coniugano, nella loro realizzazione, il presente e il passato, la memoria dei ruderi e il moderno uso.