Search results for " Reverse"

showing 10 items of 243 documents

Competing endogenous RNA and interactome bioinformatic analyses on human telomerase.

2014

We present a classic interactome bioinformatic analysis and a study on competing endogenous (ce) RNAs for hTERT. The hTERT gene codes for the catalytic subunit and limiting component of the human telomerase complex. Human telomerase reverse transcriptase (hTERT) is essential for the integrity of telomeres. Telomere dysfunctions have been widely reported to be involved in aging, cancer, and cellular senescence. The hTERT gene network has been analyzed using the BioGRID interaction database (http://thebiogrid.org/) and related analysis tools such as Osprey (http://biodata.mshri.on.ca/osprey/servlet/Index) and GeneMANIA (http://genemania.org/). The network of interaction of hTERT transcripts h…

Regulation of gene expressionGeneticsAgingbiologyCompeting endogenous RNAProtein subunitRNAComputational BiologyInteractomeTelomereCell biologyHistoneGene Expression Regulationbiology.proteinHumansRNATelomerase reverse transcriptaseRNA MessengerGeriatrics and GerontologyTelomeraseProtein BindingRejuvenation research
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Comparative modelling study on enantioresolution of structurally unrelated compounds with amylose-based chiral stationary phases in reversed phase li…

2020

[EN] Polysaccharide-based chiral stationary phases (CSPs) are the most used chiral selectors in HPLC. These CSPs can be used in normal, polar organic and aqueous-organic mobile phases. However, normal and polar organic mobile phases are not adequate for chiral separation of polar compounds, for the analysis of aqueous samples and for MS detection. In these situations, reversed phase conditions, without the usual non-volatile additives incompatible with MS detection, are preferable. Moreover, in most of the reported chiral chromatographic methods, retention is too large for routine work. In this paper, the chiral separation of 53 structurally unrelated compounds is studied using three commer…

Resolution (mass spectrometry)Reversed phase liquid hromatography010402 general chemistryMass spectrometry01 natural sciencesBiochemistryHigh-performance liquid chromatographyAmylose-based chiral stationary phasesMass SpectrometryAnalytical Chemistrychemistry.chemical_compoundAmylosePhase (matter)Least-Squares AnalysisAcetonitrileEnantioresolution modelling and descriptionChromatography High Pressure LiquidChromatography Reverse-PhaseAqueous solutionChromatography010401 analytical chemistryOrganic ChemistryDiscriminant partial least squaresStereoisomerismGeneral MedicineReversed-phase chromatography0104 chemical sciencesModels ChemicalchemistryFeature selectionRegression AnalysisAmyloseJournal of Chromatography A
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A new design approach for customised medical devices realized by additive manufacturing

2020

AbstractThe aim of this work is the design of a new customised elbow orthosis completely realized by Additive Manufacturing and the development of generative algorithms for parametric modelling and creation of 3D patterns to be adapted to the CAD model. This work describes a method to perfect the design of a custom elbow orthosis. A reverse engineering approach has been used to digitalize the patient’s arm and the subsequent CAD modelling of the structure of the custom elbow orthosis has been performed. In particular, two algorithms have been implemented for the creation of 3D patterns and Voronoi tessellations. Subsequently, FEM analyses have been carried out to validate the design. Finall…

Reverse engineering0209 industrial biotechnologyEngineering drawingbusiness.industryComputer scienceCAD02 engineering and technology021001 nanoscience & nanotechnologycomputer.software_genreIndustrial and Manufacturing EngineeringTorsion springFinite element method020901 industrial engineering & automationSoftwareIndustrial designModeling and Simulation0210 nano-technologyVoronoi diagramEngineering design processbusinessSettore ING-IND/15 - Disegno E Metodi Dell'Ingegneria IndustrialecomputerAdditive manufacturing Computer aided design Generative design Reverse engineering Elbow orthosis
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A reverse engineering approach to measure the deformations of a sailing yacht

2016

In this work, a multidisciplinary experience, aimed to study the permanent deformations of the hull of a regatta sailing yacht is described. In particular, a procedure to compare two different surfaces of the hull of a small sailing yacht, designed and manufactured at the University of Palermo, has been developed. The first one represents the original CAD model while the second one has been obtained by means of a reverse engineering approach. The reverse engineering process was performed through an automatic close-range photogrammetry survey, that has allowed to obtain very accurate measures of the hull, and a 3D modelling step by the well-known 3D computer graphics software Rhinoceros. The…

Reverse engineeringEngineeringProcess (engineering)Mechanical engineeringCADcomputer.software_genre03 medical and health sciences0302 clinical medicine3D computer graphics softwareHull0502 economics and businessGenerative algorithmReverse engineeringSettore ING-IND/15 - Disegno E Metodi Dell'Ingegneria IndustrialeMeasure (data warehouse)business.industry05 social sciences030206 dentistryPhotogrammetryCAE toolClose range photogrammetrySailing yachtSettore ICAR/17 - DisegnoCAE tools; Close range photogrammetry; Generative algorithms; Reverse engineering; Sailing yacht;businesscomputer050203 business & managementSettore ICAR/06 - Topografia E CartografiaMarine engineering
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Numerical study of the components positioning influence on the stability of a reverse shoulder prosthesis

2014

Aim of this paper is to setup a novel procedure able to analyze performances of a reverse shoulder prosthesis when different geometrical configurations are assumed. Nowadays, such a prosthesis is widely used but, because of its novelty, data in literature give poor information about performances and limits to its applicability. The activity has been divided into the following steps. At the beginning the shape of the prosthesis has been digitally acquired via a 3D scanner. Then, CAD models of all prosthetic components have been geometrically optimized in a way to obtain final entities suitable for numerical simulations. After that, CAD assemblies have been created between prosthetic componen…

ScannerEngineeringEngineering drawingbusiness.industryCADStructural engineeringStability (probability)Industrial and Manufacturing EngineeringFinite element methodStability conditionsmedicine.anatomical_structureScapulaModeling and SimulationmedicineNon linear FEM analyses · 3D scanner acquisition · Reversed shoulder prosthesis · Shoulder stability ratioHumerusShoulder jointNon linear FEM analyses 3D scanner acquisition Reversed shoulder prosthesis Shoulder stability ratiobusinessSettore ING-IND/15 - Disegno E Metodi Dell'Ingegneria Industriale
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Haem oxygenase-1 counteracts the effects of interleukin-1β on inflammatory and senescence markers in cartilage-subchondral bone explants from osteoar…

2011

IL (interleukin)-1β plays an important role in cartilage extracellular matrix degradation and bone resorption in OA (osteoarthritis) through the induction of degradative enzymes and pro-inflammatory mediators. In the present study, we have determined the consequences of HO-1 (haem oxygenase-1) induction on markers of inflammation and senescence in the functional unit cartilage–subchondral bone stimulated with IL-1β. Cartilage–subchondral bone specimens were obtained from the knees of osteoarthritic patients. Treatment with the HO-1 inducer CoPP (cobalt protoporphyrin IX) counteracted the stimulatory effects of IL-1β on IL-6, nitrite, PGE2 (prostaglandin E2), TGF (transforming growth factor)…

SenescenceCartilage Articularmedicine.medical_treatmentInterleukin-1betaDown-RegulationNitric Oxide Synthase Type IIProtoporphyrinsBone resorptionDinoprostoneOsteoarthritismedicineHumansTelomerase reverse transcriptaseProstaglandin E2Bone ResorptionRNA Small InterferingCellular SenescenceProstaglandin-E SynthasesbiologyInterleukin-6InterleukinGeneral MedicineCOPPMolecular biologyIntramolecular OxidoreductasesCyclooxygenase 2ImmunologyHeme Oxygenase (Decyclizing)Osteocalcinbiology.proteinBiomarkersmedicine.drugProstaglandin EClinical science (London, England : 1979)
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L'incremento della sostenibilità ambientale attraverso una corretta gestione dell'irrigazione.

2014

Lo scopo di questo lavoro è quello di mettere a punto, a partire dalle informazioni territoriali quali caratteristichemeteorologiche e pedologiche, uno studio capace di valutare la sostenibilità della gestione irrigua in tre ipotetiche parcelle sperimentali individuate nel territorio del sottobacino Iudeo-Bucari (TP). Sitratta di tre vigneti che rappresentano per caratteristiche morfologiche e gestionali l'intero sottobacino, ovvero una delle aree maggiormente vitate della Sicilia. Il fine è valutare la sostenibilità della gestione irrigua in termini di risparmio energetico, attraverso l'applicazione del modello di bilancio idrico FAO 56. Questo tipo di studio pone le basi per la redazione …

Settore AGR/14 - PedologiaThe purpose of this work is todevelop from spatial information such as weather and soil characteristics a study capable ofhighlighting the sustainability of irrigation management of three hypothetical experimental plots identified in the territory of the sub-basin Iudeo Bucari located western Sicily in the province of Trapani. There are three vineyards that represent for morphological characteristics and management the entire sub-basin which is one of the areas most under vines in Sicily. The aim is to assess the sustainability of irrigation management in terms of saving energy through the application of the model FAO 56 fetlock water balance. This study lays the foundation for the preparation of action plans developed to reverse negative trends in environmental resource management which are susceptible to degradation processes.
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Architecture and kinematics of forearc basins and intra-caldera resurgences: new insight from the Paola Basin (western offshore Calabria region) and …

This thesis deals with the patterns of tectonic deformation at different time and spatial scales ranging from tens to millions of years and from one to tens of kilometers, respectively. The study areas are the Campi Flegrei (Campania region, Italy) and Paola Basin (western offshore Calabria region, Italy). The Campi Flegrei and its offshore prolongation, the Pozzuoli Bay, are a laboratory for investigating volcano-tectonic deformations at 1yr-1kyr timescale and 1km spatial scale related to the dynamics of the Neapolitan Yellow Tuff (NYT) caldera and its intra-caldera resurgence. Resurgence is the late stage, long-term uplift of a collapse caldera floor to form a dome-like structure. The com…

Settore GEO/03 - Geologia StrutturaleCaldera Resurgence Reverse faults Campi Flegrei Pozzuoli BayCalabrian Arc Ionian Sea Fore-arc basin Lithospheric buckling Longshore current
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Energy assessment of a dish-Stirling system powering a reverse osmosis plant for seawater desalination

2022

Water scarcity in many regions of the world and the global demographic growth make the desalination of seawater and/or brackish an effective solution to meet the growing demand for freshwater. Nowadays, reverse osmosis has the largest share of the global installed desalination capacity. The impelling need to reduce greenhouse gas emissions has been pushing the search for sustainable technologies to produce the electricity needed to power reverse osmosis plants. Among solar technologies, little attention has been paid to the possibility of powering reverse osmosis with electricity from the dish-Stirling concentrator. To fill this knowledge gap, this paper assesses the energy-saving potential…

Settore ING-IND/11 - Fisica Tecnica AmbientaleSettore ING-IND/10 - Fisica Tecnica IndustrialeSolar desalination Dish-Stirling system Reverse osmosis Seawater desalination Energy assessment.
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Coupling CFD simulation with a simplified process model for reverse electrodialysis units

2017

Salinity gradient between two solutions is a renewable source of energy. Among the technologies able to exploit the salinity gradient, reverse electrodialysis (RED) is an electrochemical process for electrical power generation through direct conversion. Ion exchange membranes, piled alternately and separated by net spacers or membrane profiles, are the key elements of a RED stack. A multiplex phenomenology occurs in RED units; Ohmic and non-Ohmic (due to concentration changes) voltage losses and pressure drop are the main issues, and the membrane/channel configuration is crucial for the stack performance. In this framework, mathematical modelling can be a powerful tool for predictive purpos…

Settore ING-IND/24 - Principi Di Ingegneria ChimicaSettore ING-IND/26 - Teoria Dello Sviluppo Dei Processi ChimiciSettore ING-IND/25 - Impianti ChimiciSettore ING-IND/06 - FluidodinamicaSalinity gradient energy Reverse electrodialysis CFD Process modelSettore ING-IND/19 - Impianti Nucleari
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