Search results for " Runs of homozygosity"

showing 3 items of 13 documents

Genome-wide scan for Runs of Homozygosity in Valle del Belice sheep

2017

The current availability of very large numbers of single nucleotide polymorphisms (SNPs) throughout the genome makes these markers particularly suitable for the detection of genomic regions where a reduction in heterozygosity occurred and offers new opportunities to improve the accuracy of inbreeding (F) estimates. Runs of homozygosity (ROH) are contiguous lengths of homozygous segments of the genome where the two haplotypes inherited from the parents are identical. Here, we investigated the occurrence and the distribution of ROH in medium-density SNP genotypes (~ 50 000) in order to characterize autozygosity in 512 individuals of Valle del Belice sheep and identify the regions of the genom…

Settore AGR/17 - Zootecnica Generale E Miglioramento GeneticoOvineSNP50K sheep runs of homozygosity candidate genes
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Genome-wide analyses reveal population structure and identify candidate genes associated with tail fatness in local sheep from a semi-arid area.

2021

Abstract Under a climate change perspective, the genetic make-up of local livestock breeds showing adaptive traits should be explored and preserved as a priority. We used genotype data from the ovine 50 k Illumina BeadChip for assessing breed autozygosity based on runs of homozygosity (ROH) and fine-scale genetic structure and for detecting genomic regions under selection in 63 Tunisian sheep samples. The average genomic inbreeding coefficients based on ROH were estimated at 0.017, 0.021, and 0.024 for Barbarine (BAR, n = 26), Noire de Thibar (NDT, n = 23), and Queue fine de l'Ouest (QFO, n = 14) breeds, respectively. The genomic relationships among individuals based on identity by state (I…

TailCandidate geneGenotype040301 veterinary sciencesIntrogressionRuns of HomozygosityBiologyFat tailRuns of homozygositySF1-1100Polymorphism Single Nucleotide0403 veterinary scienceSettore AGR/17 - Zootecnica Generale E Miglioramento GeneticoAnimalsInbreedingAlleleLocal sheepGenomeSheepFat tail Genetic structure Local sheep Runs of homozygosity Selection signaturesHomozygote0402 animal and dairy science04 agricultural and veterinary sciencesSelection signature040201 dairy & animal scienceBreedAnimal cultureEvolutionary biologyGenetic structureAnimal Science and ZoologyGene poolGenetic structureInbreedingGenome-Wide Association StudyAnimal : an international journal of animal bioscience
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Relationship between inbreeding and milk production traits in two Italian dairy sheep breeds.

2022

The effects of inbreeding in livestock species breeds have been well documented and they have a negative impact on profitability. The objective of this study was to evaluate the levels of inbreeding in Sarda (SAR, n = 785) and Valle del Belice (VdB, n = 473) dairy sheep breeds and their impact on milk production traits. Two inbreeding coefficients (F) were estimated: using pedigree (FPED), or runs of homozygosity (ROH; FROH) at different minimum ROH lengths and different ROH classes. After the quality control, 38,779 single nucleotide polymorphisms remained for further analyses. A mixed-linear model was used to evaluate the impact of inbreeding coefficients on production traits within each …

runs of homozygosityFood Animalsmixed modelgenomic informationAnimal Science and ZoologyGeneral Medicinegenomic information; inbreeding depression; mixed model; runs of homozygosityinbreeding depressionJournal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und ZuchtungsbiologieREFERENCES
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