Search results for " SOM"
showing 10 items of 346 documents
The MOOD Questionnaire: adaptation and validation of the Spanish version.
2013
El Cuestionario de Estados de Ánimo: adaptación y validación de la versión española. Antecedentes: en este estudio se analizan las propiedades psicométricas del Cuestionario de Estados de Ánimo (MOOD) en población infantil española. Este instrumento fue desarrollado para cubrir el vacío existente en la evaluación de los estados de ánimo en niños. Método: el MOOD fue administrado a una muestra de 1.489 niños (edad media= 9,11 años). Resultados: las propiedades psicométricas del cuestionario resultaron adecuadas, observándose la relación de los estados de ánimo con la competencia emocional y las quejas somáticas. Conclusiones: en base a los resultados obtenidos, el uso de esta herramienta dia…
Temporal refinement of sensory-evoked activity across layers in developing mouse barrel cortex.
2019
Rhythmic whisking behavior in rodents fully develops during a critical period about 2 weeks after birth, in parallel with the maturation of other sensory modalities and the onset of exploratory locomotion. How whisker-related sensory processing develops during this period in the primary somatosensory cortex (S1) remains poorly understood. Here, we characterized neuronal activity evoked by single- or dual-whisker stimulation patterns in developing S1, before, during and after the occurrence of active whisking. Employing multi-electrode recordings in all layers of barrel cortex in urethane-anesthetized mice, we find layer-specific changes in multi-unit activity for principal and neighboring b…
Subcortical somatosensory evoked potentials after median nerve and posterior tibial nerve stimulation in high cervical cord compression of achondropl…
2008
Abstract Children with achondroplasia may have high cervical myelopathy from stenosis of the cranio-cervical junction resulting in neurological disability and an increased rate of sudden death. To detect myelopathy we recorded somatosensory evoked potentials after median nerve (MN) and posterior tibial nerve (PTN) stimulation in 77 patients with achondroplasia aged 0.3–17.8 years (mean 2.7 years). In addition to the conventional technique of recording the cortical components and the central conduction time (CCT) we employed non-cephalic and mastoid reference electrodes to record the subcortical waveforms N13b and P13 (MN-SEP) as well as P30 (PTN-SEP), respectively, which are generated near …
Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly.
2011
ObjectiveThe aim of this study was to characterize the genetic variance of somatostatin receptor 5 (SSTR5) and investigate the possible correlation of such variants with acromegaly risk and different disease characteristics.Design and methodsThe SSTR5 gene coding region and 2000 bp upstream region was sequenced in 48 patients with acromegaly and 96 control subjects. Further, three single nucleotide polymorphisms (SNPs) were analyzed in the same group of acromegaly patients and in an additional group of 475 age- and sex-matched controls.ResultsIn total, 19 SNPs were identified in the SSTR5 gene locus by direct sequencing. Three SNPs (rs34037914, rs169068, and rs642249) were significantly ass…
Abnormal subcortical somatosensory evoked potentials indicate high cervical myelopathy in achondroplasia
1999
Children with achondroplasia may have high cervical myelopathy due to stenosis of the cranio-cervical junction resulting in neurological disability and an increased rate of sudden death. To detect myelopathy we recorded somatosensory evoked potentials (SEPs) after median nerve stimulation in 30 patients with achondroplasia aged 13 months to 18 years (mean 6 years). In addition to the conventional technique of recording the cortical N20 and the central conduction time (CCT), we employed a noncephalic reference electrode recording the subcortical waveforms N13b and P13, generated near the cranio-cervical junction. The findings were related to the clinical status and MRI results. Eighteen pati…
Effect of circulating growth hormone on muscle IGF-I protein concentration in female mice with growth hormone receptor gene disruption.
2009
Growth hormone (GH) is a potent secretague for circulating insulin-like growth factor-I (IGF-I). The purpose of this study was to examine the effect of circulating GH on muscle IGF-I protein expression using GH transgenic animal models. Three different models were used: mice that overexpress bovine GH (bGH; n=10), mice without a functional GH receptor (GHR-/-; n=10), and wildtype mice (n=10). All mice were 16-week old females and each group differed in their basic phenotypic characteristics. Immediately after euthanization the triceps surae muscle group (soleus, plantaris, and gastrocnemius muscles) was removed. IGF-I was extracted from the muscle with an acid-ethanol solution (12.5% 2N hyd…
The rs1466113 Polymorphism in the Somatostatin Receptor 2 Gene Is Associated with Obesity and Food Intake in a Mediterranean Population
2009
<i>Background:</i> A genome-wide association study identified rs1466113 (G>C) in the somatostatin receptor 2 (SSTR2) gene as one of the polymorphisms most significantly associated with body mass index (BMI). As replication is required, we examined the association between this polymorphism and anthropometric variables and food intake in a Mediterranean population. <i>Methods:</i> We studied 945 high cardiovascular-risk subjects (340 men and 605 women) aged 67 ± 6 years, participating in the PREDIMED-Valencia Study. Demographic, clinical, biochemical, dietary, genetic and anthropometric data were obtained. <i>Results:</i> We found recessive effects for t…
Somatosensory evoked potentials after posterior tibial nerve stimulation — normative data in children
2000
We report normative data of somatosensory evoked potentials to posterior tibial nerve stimulation from 47 children 4–15 years of age. We recorded near-field potentials from the peripheral nerve, the cauda equina, the lumbar spinal cord and the somatosensory cortex. Far-field potentials were recorded from the scalp electrodes with a reference at Erb's point and on the earlobe. The near-field potentials N8 (peripheral nerve) and P40 (cortex) were present in all children. N20 (near-field from the cauda equina) was recorded in 38 subjects. N22 (near-field from the lumbar spinal cord), P30 and N37 ( both farfield waveforms probably generated in the brainstem) were recorded in 46 subjects each. T…
Hydrodynamic effects on the origin and quality of organic matter for bivalves: an integrated isotopic, biochemical and transplant study
2006
Different hydrodynamic conditions can affect both the origin and the quality of organic matter available to bivalve molluscs. I chose 2 environments with very different hydrodynamics (a Mediterranean lagoon open to flow and a closed pond), but similar with regard to temperature, salinity, depth, wind exposure and algae coverage, to investigate this. The lagoon was characterised by active flow and bivalve molluscs, whereas the pond was closed off from the lagoon’s main flow but characterised by mussel beds of the highest density ever observed in the western Mediterranean. Biochemical features, 13C and 15N contents of particulate and sedimentary organic matter, and isotopic signatures of domi…