Search results for " SPECT"

Developments towards in-gas-jet laser spectroscopy studies of actinium isotopes at LISOL

2015

To study exotic nuclides at the borders of stability with laser ionization and spectroscopy techniques, highest efficiencies in combination with a high spectral resolution are required. These usually opposing requirements are reconciled by applying the in-gas-laser ionization and spectroscopy (IGLIS) technique in the supersonic gas jet produced by a de Laval nozzle installed at the exit of the stopping gas cell. Carrying out laser ionization in the low-temperature and low density supersonic gas jet eliminates pressure broadening, which will significantly improve the spectral resolution. This article presents the required modifications at the Leuven Isotope Separator On-Line (LISOL) facility…

Proteomic investigations to unravel molecular physiology of the lantibiotic producer Microbispora sp. ATCC‐PTA‐5024

2013

Enhancement of antibiotic productions by plasma modified PLA electrospun membranes in Streptomyces coelicolor immobilized-cell cultivations

2017

This study, encouraging the use of PLA membranes for actinomycetes cultivations, could unveil functional insights associated with antibiotic production and S. coelicolor cellimmobilization

Model Predictive Control for Shunt Active Filters With Fixed Switching Frequency

2016

This paper presents a modification to the classical Model Predictive Control algorithm, named Modulated Model Predictive Control, and its application to active power filters. The proposed control is able to retain all the advantages of a Finite Control Set Model Predictive Control whilst improving the generated waveforms harmonic spectrum. In fact a modulation algorithm, based on the cost function ratio for different output vectors, is inherently included in the MPC. The cost function-based modulator is introduced and its effectiveness on reducing the current ripple is demonstrated. The presented solution provides an effective and straightforward single loop controller, maintaining an excel…

Extended X-ray emission in PKS 1718-649

2018

PKS 1718$-$649 is one of the closest and most comprehensively studied candidates of a young active galactic nucleus (AGN) that is still embedded in its optical host galaxy. The compact radio structure, with a maximal extent of a few parsecs, makes it a member of the group of compact symmetric objects (CSO). Its environment imposes a turnover of the radio synchrotron spectrum towards lower frequencies, also classifying PKS 1718$-$649 as gigahertz-peaked radio spectrum (GPS) source. Its close proximity has allowed the first detection of extended X-ray emission in a GPS/CSO source with Chandra that is for the most part unrelated to nuclear feedback. However, not much is known about the nature …

Wind-luminosity evolution in NLS1 AGN 1H 0707−495

2021

Ultra-fast outflows (UFOs) have been detected in the high-quality X-ray spectra of a number of active galactic nuclei (AGN) with fairly high accretion rates and are thought to significantly contribute to the AGN feedback. After a decade of dedicated study, their launching mechanisms and structure are still not well understood, but variability techniques may provide useful constraints. In this work, therefore, we perform a flux-resolved X-ray spectroscopy on a highly accreting and variable NLS1 AGN, 1H 0707-495, using all archival XMM-Newton observations to study the structure of the UFO. We find that the wind spectral lines weaken at higher luminosities, most likely due to an increasing ion…

Coupling hydrodynamics and radiation calculations for star-jet interactions in active galactic nuclei

2016

Context. Stars and their winds can contribute to the non-thermal emission in extragalactic jets. Because of the complexity of jet-star interactions, the properties of the resulting emission are closely linked to those of the emitting flows. Aims. We simulate the interaction between a stellar wind and a relativistic extragalactic jet and use the hydrodynamic results to compute the non-thermal emission under different conditions. Methods. We performed relativistic axisymmetric hydrodynamical simulations of a relativistic jet interacting with a supersonic, non-relativistic stellar wind. We computed the corresponding streamlines out of the simulation results and calculated the injection, evolut…

Application of LA-ICP-MS as a rapid tool for analysis of elemental impurities in active pharmaceutical ingredients.

2014

The control of inorganic contaminants in active pharmaceutical ingredients has a significant role in the quality control of drug products. The concentration limits for metal residues in drug products have been defined by various regulatory guidelines. Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a powerful and fast analytical technique for multi-elemental analysis. A disadvantage in using LA-ICP-MS method is the lack of matrix reference materials for validation and calibration purposes. This article focuses on the handling strategy of laboratory-made matrix calibration standards for the quantification of elemental impurities in an active pharmaceutical ingredie…

ChemInform Abstract: High-Resolution Solid-State NMR Spectroscopy of Steroids and Their Derivatives

2013

Abstract: Steroids are an important class of organic compounds containing a vast array of biologically and physiologically essential molecules. Due to their availability, relatively straightforward derivatizability, and endogeneity, they are widely used in pharmacological applications. The investigation of molecular and physicochemical properties of active pharmaceutical ingredients (APIs) in the solid state is important, because these properties are directly related to their pharmacological activity. Several methods are available for this purpose. Solid-state NMR spectroscopy offers a nondestructive and flexible technique, providing both structural and dynamic information. It can be applie…

High-Resolution Solid-State NMR Spectroscopy of Steroids and Their Derivatives

2013

Abstract: Steroids are an important class of organic compounds containing a vast array of biologically and physiologically essential molecules. Due to their availability, relatively straightforward derivatizability, and endogeneity, they are widely used in pharmacological applications. The investigation of molecular and physicochemical properties of active pharmaceutical ingredients (APIs) in the solid state is important, because these properties are directly related to their pharmacological activity. Several methods are available for this purpose. Solid-state NMR spectroscopy offers a nondestructive and flexible technique, providing both structural and dynamic information. It can be applie…