Search results for " STRESS"

Metal ions modify DNA-protecting and mutagen-scavenging capacities of the AV-153 1,4-dihydropyridine.

2019

Abstract 1,4-Dihydropyridines (1,4-DHP) possess important biochemical and pharmacological properties, including antioxidant and antimutagenic activities. AV-153-Na, an antimutagenic and DNA-repair enhancing compound was shown to interact with DNA by intercalation. Here we studied DNA binding of several AV-153 salts to evaluate the impact of AV-153 modifications on its DNA binding capacity, the ability to scavenge the peroxynitrite, to protect HeLa and B-cells cells against DNA damage. Affinity of the AV-153 salts to DNA measured by a fluorescence assay was dependent on the metal ion forming a salt in position 4 of the 1,4-DHP, and it decreased as follows: Mg > Na > Ca > Li > Rb > K. AV-153-…

The Line Element-less Method Analysis of orthotropic beam for the De Saint Venant torsion problem

2010

Abstract This paper deals with the extension of a novel numerical technique, labelled line element-less method (LEM), in order to provide approximate solutions of the De Saint Venant torsion problem for orthotropic beams having simply and multiply connected cross-section. A suitable transformation of coordinates allows to take full advantage of the theory of analytic complex functions as in the isotropic case. A complex potential function analytic in all the transformed domain whose real and imaginary parts are related to the shear stress components and to the orthotropic ratio is introduced and expanded in the double-ended Laurent series involving harmonic polynomials. An element-free weak…

Line element-less method (LEM) for beam torsion solution (truly no-mesh method)

2008

In this paper a new numerical method for finding approximate solutions of the torsion problem is proposed. The method takes full advantage of the theory of analytic complex function. A new potential function directly in terms of shear stresses is proposed and expanded in the double-ended Laurent series involving harmonic polynomials. A novel element-free weak form procedure, labelled Line Element-Less Method (LEM), has been developed imposing that the square of the net flux across the border is minimum with respect to coefficients expansion. Numerical implementation of the LEM results in systems of linear algebraic equations involving symmetric and positive-definite matrices without resorti…

Endotelin-1 and 8-isoprostanes Predict Estimated Glomerular Filtration Rate in Arterial Hypertension

2008

Endotelina-1 e 8-isoprostano predicono il GFR stimato nell’ipertensione arteriosa

2008

Plasma endothelin-1 and 8-Iso-ProstaglandinF2alpha levels are related to renal function and predict estimated glomerular filtration rate in hypertens…

2008

Numerical and experimental analysis of a pegs-wing ventilated disk brake rotor, with pads and cylinders

2005

The influence of strain rate and presence of dispersed second phases on the deformation behaviour of polycrystalline D2O ice

2018

ABSTRACTThis contribution discusses results obtained from 3-D neutron diffraction and 2-D fabric analyser in situ deformation experiments on laboratory-prepared polycrystalline deuterated ice and ice containing a second phase. The two-phase samples used in the experiments are composed of an ice matrix with (1) air bubbles, (2) rigid, rhombohedral-shaped calcite and (3) rheologically soft, platy graphite. Samples were tested at 10°C below the melting point of deuterated ice at ambient pressures, and two strain rates of 1 × 10−5 s−1 (fast) and 2.5 × 10−6 s−1 (medium). Nature and distribution of the second phase controlled the rheological behaviour of the ice by pinning grain boundary migratio…

Psychosocial work stressors and well-being: self-esteem and optimism as moderators in a one-year longitudinal sample

2003

The purpose of the present follow-up study was to investigate the roles of self-esteem and optimism in the relationship between psychosocial work stressors and well-being for a sample of Finnish employees (n=457). The data were obtained by means of questionnaires which were completed twice, in 1999 and 2000. The results of the moderated hierarchical regression analyses revealed that low levels of self-esteem and optimism had a direct negative effect on emotional exhaustion and mental distress among men employees. Furthermore, self-esteem moderated the relationships between poor organizational climate and emotional exhaustion and mental distress among male employees. Among female employees o…

Temperature in summer and children's hospitalizations in two Mediterranean cities

2016

Abstract Background and objective Children are potentially vulnerable to hot ambient temperature. However, the evidence on heat-related children's morbidity is still scarce. Our aim was to examine the association between temperatures in summer (May to September) and children's hospitalizations in two Mediterranean cities, Rome and Valencia, during the period 2001–2010. Methods Quasi-Poisson generalised additive models and distributed lag non-linear models were combined to study the relationship between daily mean temperature and hospital admissions for all natural, respiratory and gastrointestinal diseases in children under 15 years of age. Associations were summarised as the percentage of …