Search results for " STRESS"
showing 10 items of 3936 documents
Identification, cloning and environmental factors modulation of a αβ defensin from the lessepsian invasive mussel Brachidontes pharaonis (Bivalvia: M…
2015
International audience; Immunological effectors of invasive species playing a role in addressing new colonization are still poorly studied. In the present study the cDNA sequence of the defensin from a Lessepsian invasive species, the Red Sea mussel Brachidontes pharaonis, was cloned using RACE method. Defensins are a class of widely known antimicrobial peptides (AMPs), oligopeptides with a broad spectrum of targeted organisms ranging from viruses to parasites. Analysis of BpDef sequence (262 bp) revealed the presence of an ORF coding for 81 amino acids. The full-length amino acid sequence showed the highest similarity to antimicrobial peptides MGD1 and MGD2 sequence from Mytilus galloprovi…
Beneficial effects of heme oxygenase-1 up-regulation in the development of experimental inflammation induced by zymosan.
2003
Heme oxygenase-1 (HO-1) is part of the integrated response to oxidative stress. This enzyme may exert anti-inflammatory effects in some animal models, although the precise mechanisms are not fully understood. We have examined the role of HO-1 in the inflammatory response induced by zymosan in the mouse air pouch. Zymosan administration induced HO-1 protein expression in leukocytes migrating to exudates, with maximal levels in the late phase of this response (24-48 h). This was accompanied by ferritin induction and bilirubin accumulation, indicating that this enzyme is active in our model. HO-1 expression by zymosan treatment was partly reduced by aminoguanidine, suggesting the participation…
Quantifying water stress effect on daily light use efficiency in Mediterranean ecosystems using satellite data
2016
16 pages, 2 figures, 6 tables, supplemental material https://dx.doi.org/10.1080/17538947.2016.1247301
Early assessment of crop yield from remotely sensed water stress and solar radiation data
2018
Soil moisture (SM) available for evapotranspiration is crucial for food security, given the significant interannual yield variability of rainfed crops in large agricultural regions. Also, incoming solar radiation (Rs) influences the photosynthetic rate of vegetated surfaces and can affect productivity. The aim of this work is to evaluate the ability of crop water stress and Rs remotely sensed data to forecast yield at regional scale. Temperature Vegetation Dryness Index (TVDI) was computed as an indicator of crop water stress and soil moisture availability. TVDI during critical growth stage of crops was calculated from MODIS products: MODIS/AQUA 8-day composite LST at 1 km and 16-day compos…
Cytotoxicity of botanicals and isolated phytochemicals from Araliopsis soyauxii Engl. (Rutaceae) towards a panel of human cancer cells.
2020
Abstract Ethnopharmacological relevance Araliopsis soyauxii Engl. (Rutaceae) is a Cameroonian medicinal plant traditionally used to treat lung diseases, malaria, and gonorrhea. It has been demonstrated that infectious disease contribute to about 20% of all human tumours. Aims of the study (1) To perform a phytochemical investigation of the dichloromethane-methanol 1:1 extracts of the bark (ASB), roots (ASR), and leaves (ASL) from Araliopsis soyauxii; (2) to evaluate the cytotoxicity of extracts and isolated compounds; (3) to determine the mode of induction of apoptosis of ASB and kihadanin B (12). Materials and methods Fourteen constituents of the crude extracts were isolated by column chro…
De Saint-Venant flexure-torsion problem handled by Line Element-less Method (LEM)
2010
In this paper, the De Saint-Venant flexure-torsion problem is developed via a technique by means of a novel complex potential function analytic in all the domain whose real and imaginary parts are related to the shear stresses. The latter feature makes the complex analysis enforceable for the shear problem. Taking full advantage of the double-ended Laurent series involving harmonic polynomials, a novel element-free weak form procedure, labelled Line Element-less Method (LEM), is introduced, imposing that the square of the net flux across the border is minimized with respect to expansion coefficients. Numerical implementation of the LEM results in systems of linear algebraic equations involv…
Tonos condicionados por la estructura métrica y pies mínimamente recursivos en Chugach Alutiiq
2016
This article presents a reanalysis of the foot-based phonology of Chugach Alutiiq (henceforth CA), a language that displays a complex mixed ternary–binary rhythm, as well as metrically conditioned distributions of pitch, fortition and vowel lengthening. Elaborating on earlier analyses of CA that had posited some kind of ternary constituent (Hewitt, 1991, 1992; Leer, 1985a, 1985b, 1985c; Rice, 1992), we propose CA should be analyzed by means of the Internally Layered Ternary (ILT) foot, a minimal recursive foot (Prince, 1980; Selkirk, 1980), which was recently revived in a typological study of binary–ternary stress (Martínez-Paricio & Kager, 2015). It will be argued that ILT feet capture CA’…
The use of cultured hepatocytes to investigate the metabolism of drugs and mechanisms of drug hepatotoxicity.
2001
Hepatotoxins can be classified as intrinsic when they exert their effects on all individuals in a dose-dependent manner, and as idiosyncratic when their effects are the consequence of an abnormal metabolism of the drug by susceptible individuals (metabolic idiosyncrasy) or of an immune-mediated injury to hepatocytes (allergic hepatitis). Some xenobiotics are electrophilic, and others are biotransformed by the liver into highly reactive metabolites that are usually more toxic than the parent compound. This activation process is the key to many hepatotoxic phenomena. Mitochondria are a frequent target of hepatotoxic drugs, and the alteration of their function has immediate effects on the ene…
Pro-oxidant activity of indicaxanthin from Opuntia ficus indica modulates arachidonate metabolism and prostaglandin synthesis through lipid peroxide …
2014
Macrophages come across active prostaglandin (PG) metabolism during inflammation, shunting early production of pro-inflammatory towards anti-inflammatory mediators terminating the process. This work for the first time provides evidence that a phytochemical may modulate the arachidonate (AA) metabolism in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, promoting the ultimate formation of anti-inflammatory cyclopentenone 15deoxy-PGJ2. Added 1 h before LPS, indicaxanthin from Opuntia Ficus Indica prevented activation of nuclear factor-κB (NF-κB) and over-expression of PGE2 synthase-1 (mPGES-1), but up-regulated cyclo-oxygenase-2 (COX-2) and PGD2 synthase (H-PGDS), with final product…
Dual anti-oxidant and anti-inflammatory actions of the electrophilic cyclooxygenase-2-derived 17-oxo-DHA in lipopolysaccharide- and cigarette smoke-i…
2014
Abstract Background 17-Oxo-DHA is an endogenous electrophilic derivative of the omega-3 fatty acid docosahexaenoic acid (DHA) which is generated in activated macrophages by the action of cyclooxygenase-2. Methods The ability of 17-oxo-DHA to control inflammation and oxidative stress was tested in human macrophages (THP-1) and bronchial epithelial cell line (16HBE) stimulated with cigarette smoke extract (CSE) and lipopolysaccharide (LPS). All data were further confirmed using primary bronchial epithelial cells, alveolar macrophages and peripheral blood mononuclear cells. Results 17-Oxo-DHA was a strong inducer of the anti-oxidant response promoting Nrf2 nuclear accumulation, leading to the …