Search results for " STRESS"
showing 10 items of 3936 documents
Hsp10 beyond mitochondria: novel locations predict as yet undescribed roles
2010
Effects of oxidative stress on primary human endothelial cells. Potential active contribution of endothelium to inflammatory heart diseases
2007
Cigarette smoke affects heat-shock proteins in human lung fibroblasts: a proteomic study and identification of three expressed HSP10 variants differe…
2006
Oxidative stress-driven expression of myeloperoxidase in endothelial cells results in accumulation of markers of oxidative and nitrosative stress in …
2009
Endothelial cells (ECs), are able to manage with higher concentrations of ROS as well as reactive nitrogen species, respect to the other cell types. The unbalance between oxidizing species and antioxidant cellular defences has been implicated in the pathogenesis of cardiovascular diseases. While the role of MPO in the oxidative burst is well established, the effects of this enzyme on endothelial biology have only recently come to light. MPO can interact with endothelial –derived NO causing its depletion and favouring its conversion to nitrogen dioxide radical, a compound responsible of protein nitration generating 3-nitrotyrosine. Moreover, MPO is the only enzyme capable to form hypoclorous…
Salivary gland proteins alterations in the diabetic milieu
2021
AbstractSalivary glands are considered the chief exocrine glands of the mouth and physiologically contribute to the maintenance of the homeostasis of the oral cavity. They consist of the parotid, submandibular and sublingual glands, which come in pairs and are collectively called the major glands, and the minor glands, which are much smaller and are dispersed throughout the buccal cavity. Salivary glands are distinguished by their size, amount of saliva secretion and their location in the oral cavity. Salivary glands pathophysiology has been a subject of interest in various worldwide metabolic disorders, including diabetes mellitus. Diabetes mellitus (DM), a global health concern, with a pa…
FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells
2022
AbstractReplication stress (RS) is a leading cause of genome instability and cancer development. A substantial source of endogenous RS originates from the encounter between the transcription and replication machineries operating on the same DNA template. This occurs predominantly under specific contexts, such as oncogene activation, metabolic stress, or a deficiency in proteins that specifically act to prevent or resolve those transcription-replication conflicts (TRCs). One such protein is Senataxin (SETX), an RNA:DNA helicase involved in resolution of TRCs and R-loops. Here we identify a synthetic lethal interaction between SETX and proteins of the Fanconi anemia (FA) pathway. Depletion of…
The Residual Shear Strength of the Shaly and Sandy Facies of the Opalinus Clay
2018
The paper presents a comprehensive laboratory campaign carried out with the aim to asses the residual strength of the Opalinus Clay. Ring shear tests with vertical effective stress up to 1 MPa were performed on remoulded samples of two different facies of the Opalinus Clay. Test results show that the «Shaly» facies is characterized by a low range of variation of residual strength while the strength of the «Sandy» facies is very sensitive to the variation of grain size distribution. Microstructural analyses (SEM) suggest that the difference in the observed mechanical behavior of the two facies can be related to different particles arrangements along the shear surfaces.
Assessment of push-out test response of hybrid steel trussed-concrete beams by FE model
2013
Aiming to investigate the truss-concrete stress transfer mechanism in Hybrid Steel Trussed-Concrete Beams (HSTCBs), a three-dimensional nonlinear FE model is developed. The constitutive laws of the steel composing the plates and the bars is modeled by means of a quadri-linear law, while the concrete behavior is defined by means of a Concrete Damaged Plasticity (CDP) model, suitable for modeling concrete and brittle materials. The CDP model uses the concept of isotropic damaged elasticity in combination with isotropic tensile and compressive plasticity and is able to properly account for the concrete confinement effect. Two main failure mechanisms are considered, namely the tensile cracking …
Shear-flexure interaction of RC elements strengthened with FRP sheets
2005
An approximate physical model for evaluation of the M-V interaction resistance domains for concrete elements strengthened with FRP sheets is presented. The reliability of the model in predicting flexureshear capacity is verified by a comparison with the results of several experimental tests.
COMPORTAMENTO CICLICO DI PANNELLI SOTTILI IN ACCIAIO
2013
abstractita La memoria riporta i risultati di indagini sperimentali su pareti sottili in acciaio sottoposte ad azioni cicliche, ponendo in risalto le capacità dissipative. Le prove sono state condotte presso il laboratorio DISMAT di Canicattì (AG)su modelli in scala 1:2. I risultati evidenziano le riserve di resistenza dei pannelli in fase post critica. Results of experimental tests on Steel Plate Shear Wall (SPSW) placed in steel frames subjected to cyclic actions are presented, stressing the dissipative capacity of the system. The tests were performed at the DISMAT laboratory in Canicattì (AG) on scale specimens. The surrounding frame is made by HEA 160 beam and columns with pinned joint,…