Search results for " STRESS"
showing 10 items of 3936 documents
Characterization and enhancement of resilience to the effects of social stress on the rewarding properties of cocaine in male mice
2022
El principal foco de interés en la presente Tesis Doctoral es estudiar la resiliencia a desarrollar un trastorno por consumo de cocaína tras la exposición a estrés. Para ello utilizamos modelos animales de estrés social (la derrota social repetida intermitente, DSRI) y de efectos reforzantes de las drogas (el paradigma de Condicionamiento de Preferencia de Lugar, CPL), ya que en estudios previos hemos demostrado que la exposición a DSRI incrementa los efectos reforzantes de la cocaína en el CPL (García-Pardo y cols., 2019; Calpe-López y cols., 2020). Nuestro objetivo es identificar a los animales resilientes a este efecto de la DSRI, caracterizar su comportamiento tras el estrés, estudiar s…
Oxidative Stress and Cognitive Alterations Induced by Cancer Chemotherapy Drugs: A Scoping Review
2021
Cognitive impairment is one of the most deleterious effects of chemotherapy treatment in cancer patients, and this problem sometimes remains even after chemotherapy ends. Common classes of chemotherapy-based regimens such as anthracyclines, taxanes, and platinum derivatives can induce both oxidative stress in the blood and in the brain, and these effects can be reproduced in neuronal and glia cell cultures. In rodent models, both the acute and repeated administration of doxorubicin or adriamycin (anthracyclines) or cisplatin impairs cognitive functions, as shown by their diminished performance in different learning and memory behavioural tasks. Administration of compounds with strong antiox…
A single bout of physical exercise does not affect young adults’ executive functions
2020
Summary Study aim. The purpose of the current study is to determine the impact of single bouts of physical exercise of different duration and intensity on young adults’ executive functions. Material and methods. The study employed 81 participants (37 females, 44 males) ranging between 19 and 39 years (mean age: 24.6 ± 4.08 years; mean height: 168 ± 9.67 cm; mean weight: 67.2 ± 13.0 kg). The executive functions were assessed through the Stroop task, the Tower of London test, and the Corsi block test. Participants were randomly assigned to one of the three experimental conditions (30-second Wingate test condition, an incremental intensity exercise test, and a submaximal constant-intensity tes…
Intensified Job Demands and Cognitive Stress Symptoms : The Moderator Role of Individual Characteristics
2020
Intensified job demands (IJDs) originate in the general accelerated pace of society and ever-changing working conditions, which subject workers to increasing workloads and deadlines, constant planning and decision-making about one’s job and career, and the continual learning of new professional knowledge and skills. This study investigated how individual characteristics, namely negative and positive affectivity related to competence demands, and multitasking preference moderate the association between IJDs and cognitive stress symptoms among media workers (n = 833; 69% female, mean age 48 years). The results show that although IJDs were associated with higher cognitive stress symptoms at wo…
Risposte agli stress ambientali in CYSTOSEIRA (C. AGARDH): effetti della temperatura sul contenuto dei composti fenolici
2012
Phenolic compounds are secondary metabolites involved in different protection mechanisms as, for example, against grazers, epiphytes and UV radiation. Seasonal variations of phenolic content in C. amentacea were analysed and laboratory experiments, in which C. amentacea was exposed to an increase of temperature (258C and 308C), were performed. Total phenolic content (TPC) was determined colorimetrically with the Folin–Ciocalteu reagent. In C. amentacea, a seasonal pattern in TPC was observed, with a maximum value in winter-spring. C. amentacea responded significantly to the temperature treatments with a consistent decrease in TPC after 48 h.
SHEAR RESISTANCE OF R/C BEAMS PROVIDED WITH DIFFERENTLY-INCLINED TRANSVERSE REINFORCEMENT
2012
The model for the evaluation of shear resistance of reinforced concrete member provided with transverse web reinforcement, derived by Nielsen (1999) on the basis of the variable inclination stress field approach, is generalized here to predict the shear strength of r.c. beams equipped with two sets of differently-inclined transversal web reinforcement and longitudinal skin reinforcement. Numerical analyses emphasize the efficiency of double inclined web transverse reinforcement in providing shear strength to beams.
Evidence of oxidative stress in very long chain fatty acid--treated oligodendrocytes and potentialization of ROS production using RNA interference-di…
2011
X-linked adrenoleukodystrophy (X-ALD) and pseudo neonatal adrenoleukodystrophy (P-NALD) are neurodegenerative demyelinating diseases resulting from the functional loss of the peroxisomal ATP-binding cassette transporter D (ABCD1) and from single peroxisomal enzyme deficiency (Acyl-CoA oxidase1: ACOX1), respectively. As these proteins are involved in the catabolism of very long chain fatty acids (VLCFA: C24:0, C26:0), X-ALD and P-NALD patients are characterized by the accumulation of VLCFA in plasma and tissues. Since peroxisomes are involved in the metabolism of reactive oxygen species (ROS) and nitrogen species (RNS), we examined the impact of VLCFA on the oxidative status of 158N murine o…
Increased susceptibility of microcytic red blood cells to in vitro oxidative stress.
1995
Oxidative damage to erythrocytes in thalassaemia has been related to generation of free radicals by an excess of denaturated alpha- or beta-globin chains, intracellular iron overload and low concentration of normal haemoglobin (HGB). Two good indicators of such oxidative damage are the high red blood cell (RBC) malonyldialdehyde (MDA) production detected following exogenous oxidant stress and the decrease of pyrimidine 5'-nucleotidase (P5N), the most sensitive enzyme to SH-group damage in vivo. Conflicting data, however, have so far accumulated in the literature concerning differences in oxidative damage between the different forms of thalassaemia and iron deficiency anaemia (IDA). In the p…
Construction stages of cable-stayed bridges with composite deck
2012
A cable-stayed bridge is built by following a construction sequence of different subsequent stages that imply changes of the geometric configuration, restraints and consequently stress and strain patterns. A study is presented about stay stressing sequences in cable-stayed bridges with composite deck for the case of construction made by the cantilever method. Initial cable forces are found through partial elastic schemes of construction stages. Different stay stressing procedures are implemented and a comparison between them is proposed in order to evaluate the differences in terms of deformed shape and internal force distribution of the deck and the pylon. Results can be useful to give pra…
Modellistica agro-idrologica per la stima dei consumi traspirativi di colture Mediterranee e schematizzazione della funzione di stress idrico
2014
I modelli di simulazione agro-idrologica permettono la schematizzazione dei fenomeni che si manifestano nel sistema suolo-vegetazione-atmosfera (SVA) su un ampio range di scale spaziali e temporali. Ogni singolo comparto del sistema è caratterizzato da comportamenti complessi dovuti, ad esempio, alle strategie adattative della pianta in risposta a condizioni di deficit idrico del suolo. Con riferimento a quest’ultimo aspetto, nella stima degli attingimenti radicali e quindi dei consumi traspirativi effettivi, di cruciale importanza risulta la corretta schematizzazione della funzione di stress idrico, descritta in generale utilizzando coefficienti riduttivi della traspirazione potenziale in …