Search results for " Sam"

Causal complexity of new product development processes : a mechanism-based approach

2018

The outcomes of new product development (NPD) processes are dependent on the interplay of several interdependent activities. One product development activity can be dependent on the presence or absence of other activities, different kinds of NDP processes may lead to the same outcome, and specific kinds of activities may have a positive effect in one process but no effect in other processes. However, we currently lack means to examine and explain this causal complexity inherent in NPD processes. To address this issue, we introduce mechanism-based approach as a way to capture conjunctural and equifinal causal relations. We build this approach on the philosophical literature on mechanism-base…

Sample Preparation for Mass-spectrometry-based Proteomics Analysis of Ocular Microvessels

2019

The use of isolated ocular blood vessels in vitro to decipher the pathophysiological state of the eye using advanced technological approaches has greatly expanded our understanding of certain diseases. Mass spectrometry (MS)-based proteomics has emerged as a powerful tool to unravel alterations in the molecular mechanisms and protein signaling pathways in the vascular beds in health and disease. However, sample preparation steps prior to MS analyses are crucial to obtain reproducible results and in-depth elucidation of the complex proteome. This is particularly important for preparation of ocular microvessels, where the amount of sample available for analyses is often limited and thus, pose…

Feasibility of shotgun urinary proteomics for investigating prematurely born preschoolers (PBP)

2016

Background: Preterms and twins are at higher risk of respiratory morbidity later in life. Advances in proteomic approaches may allow the characterization of biomarkers involved in respiratory diseases (Mauri et al. Imm. Lett. 2014;162:2-10). Gel-free approach quantitatively identify differentially expressed proteins in relation to physiopathological conditions (Mauri&Dehò, Meth Enzymology 2008;447:99-117). This can improve the clinical reliability of the next generation of biomarkers to discriminate multiple phenotypes of childhood respiratory diseases. Aim: To assess the ability of gel-free proteomics for identifying specific protein profiles related to PBP. Methods: Urine samples were…

Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis

2022

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A performance evaluation of the expert system 'Jaundice' in comparison with that of three hepatologists.

1991

The diagnostic performance of an Expert System (Jaundice) designed to discriminate between different causes of jaundice was evaluated in a test sample of 200 consecutive in-patients with serum bilirubin greater than or equal to 51 mumol/l. The average probability assigned to true diagnosis, the non-error rate and the overall accuracy were, respectively, 55%, 77% and 70%. The Expert System's discriminatory ability in probabilistic prediction, assessed by a method based on continuous functions of the diagnostic probabilities (Brier score) was good. We also compared the ability of our Expert System to that of three experienced hepatologists, who were required to give a diagnosis in 20 cases fo…

Mineralogical and Chemical Records of Icelandic Dust Sources Upon Ny-Ålesund (Svalbard Islands)

2018

This work aims to identify the geochemical and mineralogical markers of Icelandic dust and to differentiate it from the dust of local origin deposited at the Ny-Ålesund station. We characterized representative sediment samples from Iceland and Svalbard and compared them to a set of aerosol samples collected in Ny-Ålesund to check the existence and type of the mineralogical markers. The sediment samples were analyzed by X-ray diffraction (XRD) to detect the mineralogical constrain of the geochemical markers. Both aerosol and sediment samples were examined by scanning electron microscopy coupled with EDS microanalysis (SEM-EDS) and image analysis to detect and to provide a morpho-chemical cha…

FC10.06 What is a Psychiatrist? What are They Really Doing? A Qualitative Study Combining Focus Groups and Work Sampling

2000

Parenting behavior and psychodynamic conflicts: Cross-sectional findings in a normative sample of adolescents and their parents

2021

Prevalence of nocturnal asthma in a general population sample: determinants and effect of aging.

2000

Nocturnal asthma (NA) is important because of clinical and prognostic implications. Previous data on prevalence may be overestimated, because they are derived from selected series. Observations on monitoring of peak expiratory flow in elderly asthmatics suggested that prevalence of NA may increase with age. This study was designed to estimate the prevalence of NA-related symptoms in a sample drawn from a general population and evaluate the role of aging. Subjects (1,100, mean age 41.9, SD 22.8 years) were randomly selected from the lists of seven general practitioners. A questionnaire on nighttime and morning NA-associated symptoms was used and frequency of occurrence was rated as never, so…

Chronic obstructive lung disease “expert system”: Validation of a predictive tool for assisting diagnosis

2018

Purpose: The purposes of this study were development and validation of an expert system (ES) aimed at supporting the diagnosis of chronic obstructive lung disease (COLD). Methods: A questionnaire and a WebFlex code were developed and validated in silico. An expert panel pilot validation on 60 cases and a clinical validation on 241 cases were performed. Results: The developed questionnaire and code validated in silico resulted in a suitable tool to support the medical diagnosis. The clinical validation of the ES was performed in an academic setting that included six different reference centers for respiratory diseases. The results of the ES expressed as a score associated with the risk of su…