Search results for " Sang"
showing 10 items of 268 documents
Circulation du sang et circulation du savoir, le rôle des voyages dans la découverte de la circulation du sang
2004
A systematic overview of the first pasteurised VWF/FVIII medicinal product, Haemate P/Humate -P: history and clinical performance
2008
Patients with von Willebrand disease (VWD) and haemophilia A (HA) lack, to varying degrees, the von Willebrand factor (VWF) and coagulation factor VIII (FVIII) that are critical for normal haemostasis. These conditions in turn make patients prone to uncontrolled bleeding. Historically, patients with severe forms of VWD or HA were crippled before adulthood and their life expectancy was significantly reduced. Over the past decades, specific coagulation factor replacement therapies including Haemate P, have been developed to help patients achieve and maintain normal haemostasis. Haemate P is a human, plasma-derived VWF/FVIII medicinal product, which was first licensed in Germany in 1981 for th…
Efectos de la donación de la sangre del cordón umbilical sobre la madre
2022
Introducción: La donación de sangre de cordón umbilical, es una de las fuentes principales para la obtención de células madre hematopoyéticas pluripotenciales, y un tratamiento potencialmente curativo, sobre todo, en pacientes con hemopatías malignas. La hemorragia postparto en la actualidad, es la principal causa de muerte materna en los países de bajos recursos y el 25% de las muertes maternas a nivel global, apareciendo de forma súbita e inesperada incluso sin ningún factor de riesgo. En la praxis actual, coexisten dos tendencias contrapuestas, respecto al volumen de sangre intraplacentaria tras el nacimiento y su relación con la expulsión placentaria. Una, que tiende a disminuir el volu…
Evaluation of Bone Marrow CD8+ tissue-Resident Memory T Cells in Multiple Myeloma
2019
Background: CD8+ T cell responses are an essential component of the adaptive immune system. After resolution of infection a small population of memory cells is formed. In relation to circulatory patterns, different subsets of memory CD8+ T cells can be identified: the central memory (CM) and the effector memory T cells (EM) (Martin MD, et al., Front Immunol. 2018). In addition, it has been described a subset of resident memory T cells (TRM) permanently living in peripheral tissues, including the bone marrow (BM) (Di Rosa F., et al., Nat Rev Immunol. 2016). It is conceivable that these cells can contribute to the defence toward haematological tumours infiltrating the BM. Therefore, we perfor…
Possiamo usarle in sostituzione dei cumarinici? Possiamo usarle quando pensiamo che il rischio emorragico da cumarinici sia troppo elevato?
2008
Análisis de la introducción del protocolo de ahorro de sangre de cirugía cardíaca en un hospital terciario
2018
Antecedentes: En la última década, todos los sistemas de salud avanzados están implantando programas de ahorro de sangre siguiendo las recomendaciones de Sociedades Europeas y Americanas que han propuesto guías clínicas para el ahorro de sangre, siguiendo un enfoque multidisciplinar y multimodal. La reducción en el consumo lleva emparejado una reducción de complicaciones asociadas a la transfusión, mejora de resultados clínicos y reducción de costes. La cirugía cardiaca es una de las especialidades quirúrgicas con mayor riesgo hemorrágico, tanto por la intervención quirúrgica en sí misma, como por la influencia farmacológica a la cual se ve sometido el paciente en el periodo perioperatorio.…
Effect of 18:3 n-3 geometrical isomers of heated linseed oll on the biosynthesis of arachidonic acid in rat
1990
Abstract The influence of dietary heated linseed oil on the fatty acid composition of rat liver, platelet and plasma phospholipids (PL) with particular reference to the metabolism of linoleic acid (18:2 n-6) were studied. Δ6 and Δ5 desaturase activities and fatty acid composition of hepatic microsomal total lipids (TL) also were determined. Two groups of male weanling rats were fed, for 6 weeks, diets containing 10% (in weight) of a fresh linseed oil (LO group) and of a heated linseed oil (HLO group). The contents of geometrical isomers of linolenic acid (18:3 n-3) were high in the oil heated at 240°C for 10 hours. The pattern of arachidonic acid (20:4 n-6) in the different lipid fractions …
Superficial venous thrombosis and spreading to deep veins: role of genetic risk factors for venous thromboembolism
2004
Tarsius tumpara: A New Tarsier Species from Siau Island, North Sulawesi
2008
Abstract: A new, critically endangered species of tarsier, one of the world's 25 most endangered primates, is described from the remote island of Siau, North Sulawesi, based on distinguishing characteristics of the tail tuft, pelage coloration, skull, and vocalizations. Siau is part of the Sangihe Island chain, a volcanic arc composed of islands that rise from the ocean floor. There is a single previous record of a tarsier from Siau; a skull in the Dresden Museum that Meyer (1897) classified with tarsiers from Sangihe Island as Tarsius sangirensis. Sangihe and Siau Islands are geologically separated by about 60 km of ocean that greatly exceeds 1,000 m in depth. Genetic data for the new spec…
Angiopoietin-2 plasma dosage predicts time to first treatment and overall survival in chronic lymphocytic leukemia.
2010
Abstract The clinical relevance of angiopoietin-2 (Ang2) in chronic lymphocytic leukemia (CLL) was previously suggested by the association between high Ang2, and shorter progression-free survival reported in small series of patients. Here, we evaluated Ang2 glycoprotein levels in plasma samples collected from a multicentric cohort of CLL patients (n = 316) using an enzyme-linked immunosorbent assay method, and we investigated its prognostic role in relation to time to first treatment (TTFT) and overall survival. Based on a cutoff equal to 2459 pg/mL, we divided our cohort in 2 subsets (high and low Ang2) composing 100 (31.6%) and 216 (68.4%) patients, respectively. High Ang2 was predictive …