Search results for " Schizophrenia."

Estimating Exposome Score for Schizophrenia Using Predictive Modeling Approach in Two Independent Samples: The Results From the EUGEI Study

2019

The EUGEI project was supported by the grant agreement HEALTH-F2-2010-241909 from the European Community’s Seventh Framework Programme. The authors are grateful to the patients and their families for participating in the project. They also thank all research personnel involved in the GROUP project, in particular J. van Baaren, E. Veermans, G. Driessen, T. Driesen, E. van’t Hag and J. de Nijs. Bart PF Rutten was funded by a VIDI award number 91718336 from the Netherlands Scientific Organisation.

The GiSAS study: Rationale and design of a pragmatic randomized controlled trial on aripiprazole, olanzapine and haloperidol in the long-term treatme…

2011

Given the controversy about the comparative efficacy of first- compared with second-generation antipsychotics in the treatment of schizophrenia, more large-scale evidence is needed to guide clinicians in their prescriptions. Most randomized controlled trials (RCTs) were conducted in centers of excellence on highly selected samples, poorly representative of real-world patients, and often suffered conflicts of interest as they were sponsored by drug companies. The primary aim of the present study is to compare the effectiveness of haloperidol, olanzapine and aripiprazole in a representative sample of schizophrenia patients. The GiSAS trial is an open-label, independent, pragmatic RCT in Itali…

Common variants conferring risk of schizophrenia

2009

Schizophrenia is a complex disorder, caused by both genetic and environmental factors and their interactions. Research on pathogenesis has traditionally focused on neurotransmitter systems in the brain, particularly those involving dopamine. Schizophrenia has been considered a separate disease for over a century, but in the absence of clear biological markers, diagnosis has historically been based on signs and symptoms. A fundamental message emerging from genome-wide association studies of copy number variations (CNVs) associated with the disease is that its genetic basis does not necessarily conform to classical nosological disease boundaries. Certain CNVs confer not only high relative ris…

EPA-0424 – Impact of cognitive traning with cognitrain system on cognitive plasticity in schizophrenic patients

2014

Background In the literature we can find an increasing number of examples of successful cognitive rehabilitation of patients suffering from schizophrenia. The aim of this study was to investigate the effectiveness and impact of the CogniTrain therapeutic method on cognitive neuroplasticity in patients suffering from paranoid schizophrenia. We expected an answer to the question, whether brain is sensitive to stress and if the efficiency of cognitive rehabilitation improves as a result of using CogniTrain computer training. Subjects and methods Two groups of test subjects were recruited of patients with paranoid schizophrenia. In the first and second groups the measurements of short-term memo…

Dental implants placement in paranoid squizofrenic patient with obsessive-compulsive disorder: A case report

2017

Background Paranoid schizophrenia is a mental illness that involves no observable anatomical alteration. Main characteristic affects the personality of the individual, as well as areas of his own psychology. Case report A 33-year-old man with paranoid schizophrenia and obsessive-compulsive disorder in treatment with Haloperidol, Oxcarbazepine, Olanzapine and Seroquel is presented. Dental exploration showed widespread decay mostly cervical with numerous root fragments, agenesis of lateral incisors, impacted wisdom teeth, missing teeth and malocclusion. Treatment plan included restoration of teeth decay, extractions of root fragments and implant-supported prostheses in bilateral upper lateral…

Treatment Compliance in the Long-Term Paranoid Schizophrenia Telemedicine Study

2017

Schizophrenia is a chronic disease with a relatively high relapse rate. Different methods are introduced to improve compliance of the patients treated by psychiatrists; among them, a new and promising attitude is telepsychiatry. The 12-month clinical study of the compliance in paranoid schizophrenia was performed on the group of 199 patients. Every patient in the study was given a smartphone with the preinstalled original telemedicine platform (Telemedicine MoneoPlatform). The telemedicine system recorded every confirmation of the drug intake, and according to that, the compliance was counted as the percent of the doses of medication confirmed in relation to the planned ones. In the first m…

Opinions about people with schizophrenia among medical students: Findings from an Italian cross-sectional study.

2020

Background: Accumulating evidence suggests that stigmatisation toward people with schizophrenia (PWS) is common among healthcare professionals and represents a major barrier to care. Aim: The study aimed at comparing the opinions about PWS among Italian medical students at different stages of education. Methods: Study participants were 234 medical students, attending either the first three-years pre-clinical or the following three-years clinical stage. Participants read an unlabelled case-vignette of schizophrenia and completed the Opinions on Mental Illness Questionnaire. Results: A greater proportion of students at the clinical stage identified schizophrenia in the clinical description, c…

Un modello operativo per il trattamento degli esordi di schizofrenia

2011

Riassunto Introduzione Studi recenti mostrano un aumento dei disturbi psicotici in fase giovanile con prognosi peggiore rispetto alle forme tardive. Il presente lavoro intende valutare i potenziali benefici dell’intervento integrato precoce sugli outcome globali. Scopo dello studio Si e presa in esame l’organizzazione dei servizi nella citta di Palermo, rispetto alla quale sono da evidenziare l’integrazione degli interventi dell’UO di Psichiatria dell’Azienda Ospedaliera Universitaria Policlinico e del Dipartimento di Salute Mentale, l’integrazione degli interventi tra personale del Servizio di Neuropsichiatria dell’Infanzia dell’Azienda Sanitaria Provinciale e dell’Unita Operativa di Riabi…

GLOBAL AND REGIONAL CORTICAL THINNING IN FIRST-EPISODE SCHIZOPHRENIA PATIENTS: RELATIONSHIPS WITH CLINICAL AND COGNITIVE FEATURES

2010

The influence of risk factors on the onset and outcome of psychosis: What we learned from the GAP study

2020

The GAP multidisciplinary study carried out in South London, recruited 410 first episode of psychosis patients and 370 controls; the aim was to elucidate the multiple genetic and environmental factors influencing the onset and outcome of psychosis. The study demonstrated the risk increasing effect of adversity in childhood (especially parental loss, abuse, and bullying) on onset of psychosis especially positive symptoms. Adverse life events more proximal to onset, being from an ethnic minority, and cannabis use also played important roles; indeed, one quarter of new cases of psychosis could be attributed to use of high potency cannabis. The “jumping to conclusions” bias appeared to mediate …