Search results for " Score"

Phase I dose-escalation single centre clinical trial to evaluate the safety of infusion of memory T cells as adoptive therapy in COVID-19 (RELEASE)

2021

Abstract Background Effective treatments are still needed to reduce the severity of symptoms, time of hospitalization, and mortality of COVID-19. SARS-CoV-2 specific memory T-lymphocytes obtained from convalescent donors recovered can be used as passive cell immunotherapy. Methods Between September and November 2020 a phase 1, dose-escalation, single centre clinical trial was conducted to evaluate the safety and feasibility of the infusion of CD45RA− memory T cells containing SARS-CoV-2 specific T cells as adoptive cell therapy against moderate/severe cases of COVID-19. Nine participants with pneumonia and/or lymphopenia and with at least one human leukocyte antigen (HLA) match with the don…

Ceftazidime-avibactam use for klebsiella pneumoniae carbapenemase-producing k. pneumoniae infections: A retrospective observational multicenter study

2021

Abstract Background A growing body of observational evidence supports the value of ceftazidime-avibactam (CAZ-AVI) in managing infections caused by carbapenem-resistant Enterobacteriaceae. Methods We retrospectively analyzed observational data on use and outcomes of CAZ-AVI therapy for infections caused by Klebsiella pneumoniae carbapenemase–producing K. pneumoniae (KPC-Kp) strains. Multivariate regression analysis was used to identify variables independently associated with 30-day mortality. Results were adjusted for propensity score for receipt of CAZ-AVI combination regimens versus CAZ-AVI monotherapy. Results The cohort comprised 577 adults with bloodstream infections (n = 391) or nonba…

Vascular risk factors in Alzheimer’s disease and Mild Cognitive Impairment: population data from the Zabùt Aging Project

Background: Alzheimer's disease (AD) is the most common cause of dementia in older adults, accounting for about 60% of cases. However, autopsy studies suggested that mixed dementia, with vascular and neurodegenerative AD pathology, accounts for nearly 20% of dementia cases. Aims: Aim of the present study was to evaluate the relationship between isolated or clustered Vascular Risk Factors (VRFs)/diseases and Mild Cognitive Impairment (MCI) or AD. The study was conducted using a Sicilian population-based cohort dataset collected in low-educated, rural subjects, the Zabùt Aging Project (ZAP). The effect-modification by age, sex, education, genetic factor (APOE4 allele carrier), undernutrition,…

The Artek cup for total hip replacement of dysplastic hip joints.

2003

One specific difficulty in total hip replacement for developmental dysplasia of the hip is a shallow acetabulum with a short anteroposterior diameter. In a prospective cohort study we investigated the short-term results of the Artek cup, designed with a shallow outline and a height-reduced metal inlay for a large size 38 mm metal head, in a group of female patients with mild dysplasia of the hip.Fourteen consecutive patients with 17 dysplastic hip joints were included in the study. Their average age was 42 years. Fourteen hips had dysplasia Crowe grade I; 3 hips had dysplasia Crowe grade II. The femoral head centre was localized according to Pagnano in zone 1 in 3 cases, in zone 3 in 6 case…

El Balanced Scorecard y la reversión de las crisis de desempeño empresarial: una aplicación empírica en las empresas distribuidoras de electricidad d…

2015

Esta tesis doctoral valida la capacidad potencial del Balanced Scorecard, como sistema de gestión de las estrategias, para revertir las crisis de desempeño empresarial. La revisión del estado del arte de las investigaciones sobre: la estrategia empresarial, los sistemas de seguimiento al desempeño, así como del modelo de negocios; evidencia que la aplicación del BSC contribuye con el mejoramiento del desempeño estratégico de las organizaciones. A partir de estas consideraciones, se desarrolla un trabajo de investigación empírica en las empresas distribuidoras de electricidad de la República Dominicanas, dada la situación de crisis por la que han atravesado durante décadas, perdiendo miles d…

Evaluating protein structures determined by structural genomics consortia.

2006

Structural genomics projects are providing large quantities of new 3D structural data for proteins. To monitor the quality of these data, we have developed the protein structure validation software suite (PSVS), for assessment of protein structures generated by NMR or X-ray crystallographic methods. PSVS is broadly applicable for structure quality assessment in structural biology projects. The software integrates under a single interface analyses from several widely-used structure quality evaluation tools, including PROCHECK (Laskowski et al., J Appl Crystallog 1993;26:283-291), MolProbity (Lovell et al., Proteins 2003;50:437-450), Verify3D (Luthy et al., Nature 1992;356:83-85), ProsaII (Si…

Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy

2020

Background Oropharyngeal mucositis (OM) is one of the main side-effects of oncological therapy. There is no treatment to prevent its occurrence, but some zinc-based therapies have been proven to help in decreasing its intensity. The objective of this study was to determine the effect of zinc in OM in children with acute leukemia in the early stages of oncological treatment. Material and Methods This quasi-experimental study evaluated OM in 2 groups (control group: conventional hospital management, and experimental group: administration of 50 mg of zinc gluconate daily plus conventional hospital management). OM severity was recorded at a two-month follow-up. Results Forty-nine patients (26 i…

Estimation techniques to measure subjective quality on live video streaming in Cloud Mobile Media services

2018

Abstract The adoption of smart phones, the increased access to mobile broadband networks and the availability of public cloud infrastructures are aligning to the next generation of truly ubiquitous multimedia services, known as Cloud Mobile Media (CMM) services offering mobile video. Nevertheless, due to an inherit higher and variable end to end delay mainly as a result of the virtualization process, new challenges appear. One challenge is given by live video streaming applications when trying to keep a good Quality of Experience of the delivered video, measured in terms of a subjective video quality metric, named Mean Opinion Score (MOS). Our goal is to estimate and predict this subjective…

Using Factor Analysis Techniques to Find Out Objective Video Quality Metrics for Live Video Streaming over Cloud Mobile Media Services

2016

The increased adoption of smartphones, the access to mobile broadband networks and the availability of public Clouds allow new multimedia services, called Cloud Mobile Media Services. Under this new architecture the proliferation of live video streaming applications and the Quality of Experience (QoE) given by the final user are an issue, due to the higher and variable delay, as result of the virtualization methods used in the Clouds. Thus in this paradigm new challenges appear related to keep and estimate a good QoE in terms of a standarized subjective video quality called Mean Opinion Score (MOS). In this paper we analyze different approaches based on Factor Analysis techniques to estimat…

Investigating the possible impact of peritoneal tumor exposure amongst women with early stage cervical cancer treated with minimally invasive approac…

2021

Abstract Introduction Recent findings show a detrimental impact of the minimally invasive approach on patients with early stage cervical cancer (ECC). Reasons beyond these results are unclear. The aim of the present article is to investigate the possible role of peritoneal contamination during intracorporeal colpotomy. Methods patients with early stage cervical cancer were divided into 2 groups: no intraperitoneal exposure (N-IPE) intraperitoneal exposure (IPE) during minimally invasive surgery. Patients of the 2 groups were propensity-matched according to the major risk factors. Results 226 cases of the IPE group had a significant worst prognosis than the 142 cases of the N-IPE group (4.5-…