Search results for " Simulation"
showing 10 items of 4034 documents
Social Ontology, Collective Intentionality, and Mindreading
2013
Standard accounts of social reality take collective intentionality as the starting point of the creation and maintenance of social facts. But collective intentionality is enabled, as Searle suggests, by a more basic capacity to understand another person as an agent like oneself and as ready to engage in cooperative activities. We can coordinate our collective actions only insofar we are able to explain and predict the behavior of other persons, we can understand behavior only insofar we can mindread them, and we can mindread them only if we assume the constitutive role of rationality in action. Therefore …
On the Finite Element Modeling of the Lumbar Spine: A Schematic Review
2023
Finite element modelling of the lumbar spine is a challenging problem. Lower back pain is among the most common pathologies in the global populations, owing to which the patient may need to undergo surgery. The latter may differ in nature and complexity because of spinal disease and patient contraindications (i.e., aging). Today, the understanding of spinal column biomechanics may lead to better comprehension of the disease progression as well as to the development of innovative therapeutic strategies. Better insight into the spine’s biomechanics would certainly guarantee an evolution of current device-based treatments. In this setting, the computational approach appears to be a remarkable …
Case-specific performance of MM-PBSA, MM-GBSA, and SIE in virtual screening.
2015
In drug discovery the reliable prediction of binding free energies is of crucial importance. Methods that combine molecular mechanics force fields with continuum solvent models have become popular because of their high accuracy and relatively good computational efficiency. In this research we studied the performance of molecular mechanics generalized Born surface area (MM-GBSA), molecular mechanics Poisson-Boltzmann surface area (MM-PBSA), and solvated interaction energy (SIE) both in their virtual screening efficiency and their ability to predict experimentally determined binding affinities for five different protein targets. The protein-ligand complexes were derived with two different app…
Performance Enhancement of a Small Animal Positron Emission Tomograph based on Continuous Crystals and Silicon Photomultipliers
2017
La tomografía por emisión de positrones (PET, por sus siglas en inglés) es una técnica de Medicina Nuclear que permite obtener de manera no invasiva imágenes funcionales “in vivo” marcando un compuesto orgánico con un emisor de positrones. Los tomógrafos PET requieren un alta resolución espacial y sensibilidad para estimar con precisión la distribución del radiotrazador en el animal. Frente a los bloques pixelados comúnmente utilizados en PET, los detectores que consisten en la combinación de cristales continuos acoplados a fotodetectores segmentados pueden ofrecer una mayor eficiencia y una alta resolución espacial. Esta última depende de la precisión de los algoritmos de determinación de …
Représentation, analyse et caractérisation de surfaces rugueuses
2020
Nous présentons un projet de recherche dans lequel, nous proposons d’aborder la problématique de la représentation numérique, de l’analyse et de la caractérisation de surfaces rugueuses. La rugosité est un concept complexe, par nature multi-échelle et reposant sur l’étude du comportement local d’une surface dans un voisinage donné. Son évaluation sur les surfaces est essentielle pour de nombreux problèmes expérimentaux. Cela explique les nombreuses études réalisées dans les domaines applicatifs liés à la physique et la mécanique, là où le contrôle et la maîtrise de l’état des surfaces constituent un besoin majeur pour les industriels. Un grand nombre de paramètres conventionnels normalisés …
Conditional predictive inference for online surveillance of spatial disease incidence
2011
This paper deals with the development of statistical methodology for timely detection of incident disease clusters in space and time. The increasing availability of data on both the time and the location of events enables the construction of multivariate surveillance techniques, which may enhance the ability to detect localized clusters of disease relative to the surveillance of the overall count of disease cases across the entire study region. We introduce the surveillance conditional predictive ordinate as a general Bayesian model-based surveillance technique that allows us to detect small areas of increased disease incidence when spatial data are available. To address the problem of mult…
Highly-parallelized simulation of a pixelated LArTPC on a GPU
2023
The rapid development of general-purpose computing on graphics processing units (GPGPU) is allowing the implementation of highly-parallelized Monte Carlo simulation chains for particle physics experiments. This technique is particularly suitable for the simulation of a pixelated charge readout for time projection chambers, given the large number of channels that this technology employs. Here we present the first implementation of a full microphysical simulator of a liquid argon time projection chamber (LArTPC) equipped with light readout and pixelated charge readout, developed for the DUNE Near Detector. The software is implemented with an end-to-end set of GPU-optimized algorithms. The alg…
Spatial Cognition 2020/1: Book of abstracts : August 2-4, 2021, University of Latvia
2021
Spatial Cognition is concerned with the acquisition, development, representation, organization, and use of knowledge about spatial objects in real, virtual or hybrid environments and processed by human or artificial agents. Spatial Cognition includes research from different fields insofar as they are concerned with cognitive agents and space, such as cognitive and developmental psychology, linguistics, computer science, geography, cartography, philosophy, neuroscience, and education. Research issues in the field range from the investigation of human spatial cognition to mobile robot navigation, including topics such as wayfinding, spatial planning, spatial learning, internal and external re…
STUDY OF LARGE PELAGIC FISH LIFE-HISTORY TRAITS IN THE CENTRAL MEDITERRANEAN SEA AND PROJECTION UNDER FUTURE CLIMATE CHANGE SCENARIOS
2022
One of the most sensitive life periods for each species is the first life stages (larval and juvenile). The survival rates of pelagic fish larvae in these phases are usually very low and subject to fluctuations, consequently affecting the recruitment of new generations. From historical Tuna landing data, the stock's abundance is fluctuating, especially for Atlantic Bluefin Tuna (ABT) (Thunnus thynnus, Linnaeus, 1758) Eastern stock. It is the largest Mediterranean Tuna and one of the most expensive species in the world. Some studies hypothesized that the fluctuations are dictated by environmental factors, particularly in the early life stages. Therefore, it appears necessary to better unders…
Kinematics of the patellofemoral joint. Investigations on a computer model with reference to patellar fractures.
1990
Patellofemoral kinematics were studied on a computer model. The articulating point of the patella moves from distal to proximal during flexion, until the quadriceps tendon starts to turn around the femur tendo-femoral gliding. The pattern of patellofemoral movement consists of a gliding and rolling component, the latter at its maximum at the beginning of flexion. The pathway of the instant centers of motion moves from dorsal to ventral during flexion. Stress analysis shows that the contact area is at all times the area of maximum bending stress. The distal part of the patella is the part with mechanical stress at all angles of flexion. The conclusions to be drawn for treatment are that frac…