Search results for " Simulation"
showing 10 items of 4034 documents
Bodies That Matter: Miniaturisation and the Origin(s) of ‘Art’
2020
Small things matter, especially in the so-called ‘arts’. From the visual arts to music and literature, ‘miniatures’ are a transcultural and transhistorical phenomenon that involves our aesthetic attitudes but also our everyday life, our emotional, social and cognitive life. Miniaturisation characterises our cognitive life and, of course, the ‘cognitive life of things’ that we produce, manipulate and discard. My paper is articulated into two sections: the first gives a quick overview of the miniatures of Homo sapiens, especially those of the paleolithic age, and a brief survey of the very challenging history of miniature-interpretation in twentieth-century philosophy of culture. In the secon…
The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer
2021
Aptamers are short, single-stranded DNA or RNA oligonucleotide molecules that function as synthetic analogs of antibodies and bind to a target molecule with high specificity. Aptamer affinity entirely depends on its tertiary structure and charge distribution. Therefore, length and structure optimization are essential for increasing aptamer specificity and affinity. Here, we present a general optimization procedure for finding the most populated atomistic structures of DNA aptamers. Based on the existed aptamer LC-18 for lung adenocarcinoma, a new truncated LC-18 (LC-18t) aptamer LC-18t was developed. A three-dimensional (3D) shape of LC-18t was reported based on small-angle X-ray scattering…
Structure‐ and Interaction‐Based Design of Anti‐SARS‐CoV‐2 Aptamers
2022
Aptamer selection against novel infections is a complicated and time-consuming approach. Synergy can be achieved by using computational methods together with experimental procedures. This study aims to develop a reliable methodology for a rational aptamer in silico et vitro design. The new approach combines multiple steps: (1) Molecular design, based on screening in a DNA aptamer library and directed mutagenesis to fit the protein tertiary structure; (2) 3D molecular modeling of the target; (3) Molecular docking of an aptamer with the protein; (4) Molecular dynamics (MD) simulations of the complexes; (5) Quantum-mechanical (QM) evaluation of the interactions between aptamer and target with …
Assessing the Open Trenches in Screening Railway Ground-Borne Vibrations by Means of Artificial Neural Network
2009
Reducing ground borne vibrations in urban areas is a very challenging task in railway transportation. Many mitigation measures can be considered and applied; among these open trenches are very effective. This paper deals with the study of the effect, in terms of reduction of vertical and horizontal displacements and velocities, of the open trenches. 2D FEM simulations have been performed and several open trench configurations have been analysed varying the main geometric features such as width and depth, distance from the rail, thickness of the soil layer over the rigid bedrock, type of the ground, ratio between the depth of the trench, and the thickness of the soil layer. For quantifying t…
Application of the DORA 2D Model to some sicilian catchments
2005
Steady-State Convective Acceleration Computation in Shallow Water Equations
1995
Characterization of a cylindrical plastic β-detector with Monte Carlo simulations of optical photons
2017
In this work we report on the Monte Carlo study performed to understand and reproduce experimental measurements of a new plastic β-detector with cylindrical geometry. Since energy deposition simulations differ from the experimental measurements for such a geometry, we show how the simulation of production and transport of optical photons does allow one to obtain the shapes of the experimental spectra. Moreover, taking into account the computational effort associated with this kind of simulation, we develop a method to convert the simulations of energy deposited into light collected, depending only on the interaction point in the detector. This method represents a useful solution when extens…
Solar radiative effects of a Saharan dust plume observed during SAMUM assuming spheroidal model particles
2011
The solar optical properties of Saharan mineral dust observed during the Saharan Mineral Dust Experiment (SAMUM) were explored based on measured size-number distributions and chemical composition. The size-resolved complex refractive index of the dust was derived with real parts of 1.51–1.55 and imaginary parts of 0.0008–0.006 at 550 nm wavelength. At this spectral range a single scattering albedo ω o and an asymmetry parameter g of about 0.8 were derived. These values were largely determined by the presence of coarse particles. Backscatter coefficients and lidar ratios calculated with Mie theory (spherical particles) were not found to be in agreement with independently measured lidar data.…
Refined instability estimates for some inverse problems
2022
Many inverse problems are known to be ill-posed. The ill-posedness can be manifested by an instability estimate of exponential type, first derived by Mandache [29]. In this work, based on Mandache's idea, we refine the instability estimates for two inverse problems, including the inverse inclusion problem and the inverse scattering problem. Our aim is to derive explicitly the dependence of the instability estimates on key parameters. The first result of this work is to show how the instability depends on the depth of the hidden inclusion and the conductivity of the background medium. This work can be regarded as a counterpart of the depth-dependent and conductivity-dependent stability estim…