Search results for " Simulation"
showing 10 items of 4034 documents
Hydro-mechanical modelling of a natural slope affected by a multiple slip surface failure mechanism
2009
A coupled hydro-mechanical formulation is presented for the analysis of landslide motion during crisis episodes. The mathematical formulation is used to model a natural slope affected by a multiple slip surface failure mechanism, in which pore water pressure evolution was identified as the main cause for movement accelerations. An elasto-plastic constitutive model is adopted for the behaviour of slip surfaces. Material parameters are obtained by combining the available laboratory tests and the back analysis of some crisis episodes. After being calibrated and validated, the model is applied to improve the understanding of the physical processes involved and to predict the landslide behaviour…
An Updated Guideline for Assessing Discriminant Validity
2022
Discriminant validity was originally presented as a set of empirical criteria that can be assessed from multitrait-multimethod (MTMM) matrices. Because datasets used by applied researchers rarely lend themselves to MTMM analysis, the need to assess discriminant validity in empirical research has led to the introduction of numerous techniques, some of which have been introduced in an ad hoc manner and without rigorous methodological support. We review various definitions of and techniques for assessing discriminant validity and provide a generalized definition of discriminant validity based on the correlation between two measures after measurement error has been considered. We then review te…
Experimental analysis of flow in a laboratory flume with flexible vegetation
2011
Molecular Basis of SARS-CoV-2 Nsp1-Induced Immune Translational Shutdown as Revealed by All-Atom Simulations.
2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic represents the most severe global health crisis in modern human history. One of the major SARS-CoV-2 virulence factors is nonstructural protein 1 (Nsp1), which, outcompeting with the binding of host mRNA to the human ribosome, triggers a translation shutdown of the host immune system. Here, microsecond-long all-atom simulations of the C-terminal portion of the SARS-CoV-2/SARS-CoV Nsp1 in complex with the 40S ribosome disclose that SARS-CoV-2 Nsp1 has evolved from its SARS-CoV ortholog to more effectively hijack the ribosome by undergoing a critical switch of Q/E158 and E/Q159 residues that perfects Nsp1's interactions…
The ALICE experiment at the CERN LHC
2008
Journal of Instrumentation 3(08), S08002 (2008). doi:10.1088/1748-0221/3/08/S08002
Water effects on saccharide matrices studied with molecular dynamics
2013
Mechanisms of irreversible aquaporin-10 inhibition by organogold compounds studied by combined biophysical methods and atomistic simulations
2021
Abstract The inhibition of glycerol permeation via human aquaporin-10 (hAQP10) by organometallic gold complexes has been studied by stopped-flow fluorescence spectroscopy, and its mechanism has been described using molecular modelling and atomistic simulations. The most effective hAQP10 inhibitors are cyclometalated Au(III) C^N compounds known to efficiently react with cysteine residues leading to the formation of irreversible C–S bonds. Functional assays also demonstrate the irreversibility of the binding to hAQP10 by the organometallic complexes. The obtained computational results by metadynamics show that the local arylation of Cys209 in hAQP10 by one of the gold inhibitors is mapped int…
Relaxation of a weakly discontinuous functional depending on one control function
2008
The paper considers an optimal control problem of the typewhere the set M of admissible controls consists of all measurable vector‐functions h, which can take only two values h1 or h2. It is shown that the relaxation of this problem can be explicitly computed by rank‐one laminates.
Practice for determining friction in hydraulic winch systems
2020
This paper presents a method for estimating friction in hydraulic active heave compensated (AHC) offshore winches. The method is a two-step approach where the first step is to model the friction loss in the hydraulic motors based on data from the sub-supplier. The second step requires real-life testing, where the remaining friction losses in the winch system is identified and modeled. In this context, a practice is characterized by obtaining a friction loss estimation with the highest possible accuracy over the widest possible range of operating conditions with a limited amount of experimental work. The method benefits from the use of parametric models, sub-supplier data, and real-life meas…
Fractional calculus approach for the representation of power spectral densities and correlation functions in wind engineering
2010
The paper deals with the digital simulation of wind velocity samples by Fractional Spectral Moment function. It is shown that such a function represents a third useful way to characterize a stationary Gaussian stochastic process, alongside the power spectral density and the correlation function. The method is applied to wind velocity fields whose power spectra is given by the Kaimal’s, the Davenport’s and the Solari’s representation. It is shown that by constructing a digital filter whose coefficients are the fractional spectral moments, it is possible to simulate samples of the target process as superposition of Riesz fractional derivatives of Gaussian white noise processes.