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showing 10 items of 1641 documents
Vegetation dynamics on abandoned terraces of Sicily: the course and driving forces of succession
2007
In Mediterranean Europe, terrace landscapes can be found where 1) the orography is characterized by hills or mountains, 2) there is a high amount of stone outcrops and 3) the human need for agricultural production was quite high till the recent past. During the last century, many of these landscapes have been abandoned, due to their unsuitability for mechanized, intensive agriculture and due to the general land abandonment trend which arised in large parts of Europe. Since with land abandonment start secondary succession processes, the plant and animal communities linked to agroecosystems are replaced by other species which find their habitat in the developing succession stages. This proces…
Confocal laser scanning microscopy for the study of the morphological changes of the postextraction sites
2012
A better understanding of the remodeling process of postextraction sockets is essential in dental treatment planning. The aim of this study was to evaluate whether confocal laser scanning microscopy (CLSM) can be applied to imaging contour changes of postextraction sites, as well as to its quantification with image analysis of obtained three-dimensional images. This work describes a new application of the CLSM technique. The system used was the OLS3100-USS, LEXT model (Olympus((R))). CLSM was used for the surface analysis of the extraction site. The measurements taken with CLSM were: (1) mesio-distal distance, (2) alveolar ridge thickness, and (3) vestibular and lingual alveolar ridge heigh…
The role of digital information sources in the travel planning process
2021
World Economic Forum’s Digital Transformation Initiative emphasizes that digitalisation in tourism is transforming the industry at an exponential rate across the globe. Current tourist behaviour patterns are changing not so much in travel habits as in the ways of finding and using travel information. These digitalisation changes are evident at all travel stages starting from dreaming about the future trip, planning and booking necessary tourism services, as well as sharing information and evaluating experiences. Tourist destination organisations and companies need to make strategic decisions, when sharing information, to reach the target audience in a smart and efficient way. The purpose of…
User Preference and Channels Use in the Employment Seeking Process
Trust is a major issue for social capital theory and the word- of mouth concept. This paper compares social network sites with other media under consideration of trust and support. The research evaluates the difference between sources regarding trust and support to explain the situation of social network sites under consideration of the employment seeking process. The aim of this paper is the evaluation of the use of social network sites and private social networks by comparing these with job boards, company information, newspaper and official employment agency web pages. It is to identify the possible differences between information channels and the reasons for the use of different sources…
Sosiaalinen pääoma ja yksilötason tulokehitys Suomessa
2018
Tässä tutkimuksessa tarkastelemme yksilön sosiaalisista verkostoista muodostuvan sosiaalisen pääoman yhteyttä yksilötason tulokehitykseen. Analyysimme perustuvat vuoden 1986 elinolotutkimukseen osallistuneisiin 20–44 vuotiaisiin työllisiin ja rekisteritietoihin heidän palkkatuloistaan vuosilta 1987–1997. Tutkimuksessa erottelemme toisistaan sitovan ja silloittavan sosiaalisen pääoman muodot. Sitovan sosiaalisen pääoman mittarimme perustuu yksilön mahdollisuuteen saada apua verkostoistaan erilaisissa arkielämän tilanteissa. Silloittavaa sosiaalista pääomaa mittasimme yksilöiden yhdistysjäsenyyksien monipuolisuuden kautta. Analyysit suoritettiin paloittain jatkuvalla linea…
CYGD: the Comprehensive Yeast Genome Database.
2005
The comprehensive resource is available under http://mips.gsf.de/genre/proj/yeast/.; International audience; The Comprehensive Yeast Genome Database (CYGD) compiles a comprehensive data resource for information on the cellular functions of the yeast Saccharomyces cerevisiae and related species, chosen as the best understood model organism for eukaryotes. The database serves as a common resource generated by a European consortium, going beyond the provision of sequence information and functional annotations on individual genes and proteins. In addition, it provides information on the physical and functional interactions among proteins as well as other genetic elements. These cellular network…
Conformational Dynamics of the Dengue Virus Protease Revealed by Fluorescence Correlation and Single-Molecule FRET Studies.
2021
The dengue virus protease (DENV-PR) represents an attractive target for counteracting DENV infections. It is generally assumed that DENV-PR can exist in an open and a closed conformation and that active site directed ligands stabilize the closed state. While crystal structures of both the open and the closed conformation were successfully resolved, information about the prevalence of these conformations in solution remains elusive. Herein, we address the question of whether there is an equilibrium between different conformations in solution which can be influenced by addition of a competitive inhibitor. To this end, DENV-PR was statistically labeled by two dye molecules constituting a FRET …
In vitro studies on the activation of the hepatitis C virus NS3 proteinase by the NS4A cofactor.
1996
AbstractProteolytic processing of the nonstructural proteins of the hepatitis C virus (HCV) is mediated by two viral proteinases: the NS2-3 proteinase cleaving at the NS2/3 junction and the NS3 serine-type proteinase responsible for processing at the NS3/4A, NS4A/B, NS4B/5A, and NS5A/B sites. Activity of the NS3 proteinase is modulated by NS4A. In the absence of this cofactor processing at the NS3-dependent sites does not occur or, in the case of the NS5A/B junction, is poor but increased when NS4A is present. Although recent studies demonstrated that proteinase activation requires direct interaction between NS3 and NS4A, the mechanism by which NS4A exerts the activation function is not kno…
Tumor targeting of baculovirus displaying a lymphatic homing peptide.
2008
Background Tumor-associated cells and vasculature express attractive molecular markers for site-specific vector targeting. To attain tumor-selective tropism, we recently developed a baculovirus vector displaying the lymphatic homing peptide LyP-1, originally identified by ex vivo/in vivo screening of phage display libraries, on the viral envelope by fusion to the transmembrane anchor of vesicular stomatitis virus G-protein. Methods In the present study, we explored the specificity and kinetics of viral binding and internalization as well as in vivo tumor homing of the LyP-1 displaying virus to elucidate the applicability of baculovirus for targeted therapies. Results We demonstrated that th…
El Plano (Espadilla). Un yacimiento romano del Alto Mijares (Castellón)
2016
In this paper we study some archaeological materials found in the Roman site of El Plano (Castellón). Although today is almost entirely destroyed by agricultural work, some of the pieces studied said they were equipped with thermal baths, so it should be a settlement of some importance. Moreover ceramics collected allows occupation dating from the I to IV century AD. This is the first Roman site that has been studied in the district of Alto Mijares.