Search results for " Small"
showing 10 items of 806 documents
Impact of Demand Response Control Logic on Isolated Island's Distribution Networks
2019
The work presents the results of a study regarding the impact of some Demand Response control logics on an isolated distribution network. The proposed control is divided into precise steps in which the coordination between the general aggregator controller and the single local Energy Management Systems is developed and illustrated with details. The control is applied to the flexible loads and to the storage systems of photovoltaic plants installed at the end-users' houses and connected to the network. The study is carried out delivering a suitable network model of the island's system, with the implementation of load profiles for all the loads of the network for a total simulation time of 24…
Tuning the pH-Switch of Supramolecular Polymer Carriers for siRNA to Physiologically Relevant pH
2017
The preparation of histidine enriched dendritic peptide amphiphiles and their self-assembly into multicomponent pH-switchable supramolecular polymers is reported. Alternating histidine and phenylalanine peptide synthons allow the assembly/disassembly to be adjusted in a physiologically relevant range of pH 5.3-6.0. Coassembly of monomers equipped with dendritic tetraethylene glycol chains with monomers bearing peripheral primary amine groups leads to nanorods with a tunable cationic surface charge density. These surface functional supramolecular polycations are able to reversibly bind short interfering RNA (siRNA). The nanorod-like supramolecular polymers, their complexation with siRNA, and…
Desalination by sea wave in small islands: The case of study of Lampedusa (Italy)
2018
The paper analyses the theme of water energy nexus, investigating a specific industrial process: desalination. In particular, the paper reports a case of study, applied in the small island of Lampedusa, located at south of Sicily (Italy). As the many small islands in the middle of the Mediterranean Sea, Lampedusa presents a small electrical grid, not connected to the mainland. The electrical production is entrusted to old diesel engines, consuming fossil fuel, transported by boat from Sicily. Besides, the renewable energy sources are extremely underdeveloped in this territory, since the environmental constraints make complex the use of technologies, like wind turbines or photovoltaic panels…
Treatment of grazing-incidence small-angle X-ray scattering data taken above the critical angle
2001
The equations taking into account refraction at the sample surface in grazing-incidence small-angle X-ray scattering (GISAXS) when the angle between the incoming beam and the sample surface is slightly larger than the critical angle are derived and discussed. It is demonstrated that the refraction of both the incoming and the scattered beam at the sample surface affects the GISAXS pattern and that, when a planar bidimensional detector perpendicular to the incoming beam is used, the effect depends on the azimuthal detector angle. The smearing of the pattern depending on the size of the illuminated sample area in grazing incidence is estimated by simulations with Cauchy functions of different…
A small HSP, Lo18, interacts with the cell membrane and modulates lipid physical state under heat shock conditions in a lactic acid bacterium
2005
International audience; The small heat shock proteins (sHSP) are characterized by a chaperone activity to prevent irreversible protein denaturation. This study deals with the sHSP Lo18 induced by multiple stresses in Oenococcus oeni, a lactic acid bacterium. Using in situ immunocytochemistry and cellular fractionation experiments, we demonstrated the association of Lo18 with the membrane in O. oeni cells submitted to heat shock. The same result was obtained after exposure of cells to ethanol or benzyl alcohol, agents known to have an influence on membranes. For the different stresses, the protein was located on the periphery of the cell at membrane level and was also found within the cytopl…
Inclisiran: a small interfering RNA strategy targeting PCSK9 to treat hypercholesterolemia
2022
Introduction: Inclisiran is a novel posttranscriptional gene silencing therapy that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) synthesis by RNA interference and has a potent, dose-dependent, durable effect in lowering LDL-C, and therefore is an effective drug to treat dyslipidemia, reducing the risk for acute cardiovascular (CV) events. It is safe and well-tolerated. Areas covered: This paper aims to review the mechanism of action of inclisiran while evaluating its efficacy and safety in the treatment of dyslipidemia from data of the clinical trials in the ORION program. Expert opinion: Data from the clinical trials in the ORION program demonstrated efficacy and safety o…
A stochastic model of seed dispersal pattern to assess seed predation by ants in annual dry grasslands
2005
A combined field experiment and modelling approach has been used to provide evidence that ants may be responsible for an observed lower patchiness and higher plant diversity in the neighbourhood of ant nests, within Mediterranean dry grasslands belonging to the phytosociological class Tuberarietea guttatae. The hypothesis was that seeds occurring in clumps may have an higher probability to be harvested than seeds having a scattered distribution. In order to test this hypothesis, four analysis steps have been performed. First, the seed productivity and dispersal pattern was recorded for four plant species found, either more abundant beside the ant nests (Tuberaria guttata, Euphorbia exigua) …
Words without meaning? Examining sustainable development terminology through small states and territories
2021
Small states and territories have plenty of examples to offer of sustainable development as well as for analysing the terminology used in sustainable development. This paper uses conceptual discussion supported by specific examples from small states and territories to explore these issues, demonstrating limitations and improvements to contemporary sustainable development terminology. The Sustainable Development Goals (SDGs) frequently illustrate the points, for which this paper examines water, waste, and energy. These three are built on for examining climate change through a slightly polemical discussion which mirrors the polemics of sustainable development terminology. Small states and ter…
Financial literacy, value creation and firm performance. An investigation of Italian small and medium enterprises
2023
This article aims to determine the influence of entrepreneurs’ financial literacy for the growth of SMEs’ value. The paper verifies the hypothesis that there is a significant relationship between financial literacy and value creation, as indicated by economic value added (EVA®). The study analyses 162 Italian SMEs operating in the textile and clothing sector. The analysis period is between 2011 and 2013. Regression analysis and correlation analysis have been applied to test the hypotheses. The results suggest a positive and significant relationship between financial literacy and the variables that drive the value creation. Greater financial literacy allows SMEs to optimise their capital str…
Characterization of murine monoclonal antibodies against the Ro52 autoantigen
1997
SUMMARY Immunization of BALB/c mice with purified recombinant human Ro52 protein resulted in three anti-Ro52 MoAbs termed 2E7, 4C6 and 4F11. All anti-Ro52 MoAbs specifically reacted with recombinant human Ro52 protein, and also with Ro52 protein in total extracts of all human cell lines analysed, including the epithelial cell line HeLa, the B cell line Raji, the bladder carcinoma cell line RT112, and a fibroblast cell line derived from patients with xeroderma pigmentosum. The anti-Ro52 MoAbs were able to immunoprecipitate the recombinant human Ro52 protein expressed in wheat germ extract, but failed to precipitate hY RNAs from cell extracts. The staining pattern of the MoAbs strongly differ…