Search results for " Small"

Double-balloon enteroscopy-facilitated cyanoacrylate-injection endotherapy of small-bowel varices: an international experience from 2 European tertia…

2019

Background and Aims Small-bowel varices (SBVs) are an uncommon consequence of portal hypertension. Radiologic intervention is usually considered for first-line management. When radiologic intervention is not possible, management options become very limited. The aim of this study was to evaluate the usefulness of double-balloon enteroscopy (DBE)-facilitated cyanoacrylate-injection endotherapy of SBVs. Methods This was a retrospective review of DBE-facilitated cyanoacrylate-injection endotherapy of SBVs (December 2015 to October 2016). Results Ten DBEs were performed in 6 patients (4 women; median age, 68.5 years). No radiologic or surgical options were deemed feasible. Thirteen nests of SBVs…

Current status of double balloon enteroscopy with focus on the Wiesbaden results.

2006

Balloon Enteroscopy: Single- and Double-Balloon Enteroscopy

2009

Balloon enteroscopy is a method that allows endoscopic inspection of the entire small bowel, or large parts of it, while simultaneously making it possible to obtain histologic samples and carry out treatment measures. Studies of double-balloon enteroscopy (DBE) have confirmed the high diagnostic yield of the procedure, with an acceptably low complication rate (approximately 1% for diagnostic DBE and 3% to 4% for therapeutic DBE). The principal indication for the procedure is midgastrointestinal bleeding, that is, when the bleeding source is located in the small bowel. With good patient selection, the diagnostic yield here is 70% to 80%, and this has a substantial influence on subsequent tre…

Entrepreneurship training for new ventures

2009

Several studies in the field of international entrepreneurship have indicated the inadequacy of public policy support for new ventures and called for more tailored training programs. This paper introduces a training program created for new ventures in Central Finland and analyzes its benefits and shortcomings using a qualitative case study. The findings reveal that the training program provided useful knowledge on how to develop a business further and how to make it understandable and attractive to a funder. However, the findings also indicate that there is a need for cultural adaptation: the training program developed originally for U.S. new ventures was not fully adapted for the needs of …

Small heat shock proteins and the cytoskeleton: an essential interplay for cell integrity?

2012

Abstract The cytoskeleton is a highly complex network of three major intracellular filaments, microfilaments (MFs), microtubules (MTs) and intermediate filaments (IFs). This network plays a key role in the control of cell shape, division, functions and interactions in animal organs and tissues. Dysregulation of the network can contribute to numerous human diseases. Although small HSPs (sHSPs) and in particular HSP27 (HSPB1) or αB-crystallin (HSPB5) display a wide range of cellular properties, they are mostly known for their ability to protect cells under stress conditions. Mutations in some sHSPs have been found to affect their ability to interact with cytoskeleton proteins, leading to IF a…

“Houses for One Euro” and the Territory. Some Estimation Issues for the “Geographic Debt” Reduction

2020

The phenomenon of the “houses for one Euro” is the epitome of the progressive and increasing abandonment of the inland territories in which many small towns are affected by continuous and unstoppable depopulation. This process, mostly affecting the southern and insular Italian regions, have been triggered by the quick industrial development started after the second post-war, led by the northern regions, that deeply and irreversibly modified the anthropography of the whole country until now. The impoverishment of a wide part of the Italian territory, is one of the many issues connected to the social-territorial justice that is the original topic by which appraisal and valuation, that is scie…

Near zero energy islands in the Mediterranean: Supporting policies and local obstacles

2014

Abstract Based on a recent technical–economical analysis on the island of Pantelleria, a policy feasibility study for a complete upgrading of the energy system of this Mediterranean Island is carried out. Pantelleria, situated between Sicily and Africa, owns a large potential in terms of renewable energy resources, although there are some obstacles in turning it into a Near Zero Energy system. Starting from a deep energy system audit, the study proposes the project for a near zero energy island, through the efficient transformation of the different existing natural energy resources into electrical energy and heat: the solar, the wind-based and the geothermal systems. In this way, the island…

On thermoeconomics of energy systems at variable load conditions: integrated optimization of plant design and operation

2007

Abstract Thermoeconomics has been assuming a growing role among the disciplines oriented to the analysis of energy systems, its different methodologies allowing solution of problems in the fields of cost accounting, plant design optimisation and diagnostic of malfunctions. However, the thermoeconomic methodologies as such are particularly appropriate to analyse large industrial systems at steady or quasi-steady operation, but they can be hardly applied to small to medium scale units operating in unsteady conditions to cover a variable energy demand. In this paper, the fundamentals of thermoeconomics for systems operated at variable load are discussed, examining the cost formation process an…

Ezetimibe with or without simvastatin increases small dense low-density lipoproteins in healthy men – a randomized trial

2010

Inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase as possible mechanism to readthrough premature termination codons (UGAs) of th…

2022

Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for the CFTR chloride channel. About 10 % of the mutations affecting the CFTR gene are "stop" mutations, which generate a Premature Termination Codon (PTC), thus resulting in the synthesis of a truncated CFTR protein. A way to bypass PTC relies on ribosome readthrough, that is the capacity of the ribosome to skip a PTC, thus generating a full-length protein. “TRIDs” are molecules exerting ribosome readthrough and for some of them the mechanism of action is still under debate. By in silico analysis as well as in vitro studies, we investigate a possible mechanism of action (MOA) by whic…