Search results for " Specialist"

showing 10 items of 770 documents

Abitare nel reale. Dalla crisi della periferia alla tessitura di nuove relazioni contestuali

2019

I progetti redatti per “Palermo Sud-Est” sono il risultato di un Laboratorio di Laurea strutturatosi attraverso incontri, seminari, comunicazioni specialistiche, esposizioni critiche, che – in una strategia condivisa – ha visto ogni studente elaborare il proprio lavoro nel confronto con gli altri attori del Laboratorio stesso. La ricerca sui “progetti urbani” è stata impostata di modo che ogni laureando fosse messo a conoscenza dei progetti svolti nello stesso ambito territoriale dai colleghi che l’avevano preceduto, così da poter operare in continuità e contribuire a formulare un ragionamento unitario, nel quale ogni progetto costituisse continuazione, verifica o anche variante dei precede…

The projects prepared for "Palermo South-East" are the result of a Graduate Laboratory structured through meetings seminars specialist communications critical exhibitions which - in a shared strategy - saw each student elaborate their work in comparison with others actors of the same Laboratory. The research on "urban projects" was set so that each graduating student was made aware of the projects carried out in the same geographical area by the colleagues who had preceded it so as to be able to operate in continuity and contribute to formulating a unitary reasoning in which each project constituted continuation verification or even variant of the previous ones. These coordinated works have pursued two fundamental objectives: the strengthening of infrastructures and the establishment of specialized public buildings with superior functions aimed at requalifying and regenerating various critical situations with particular attention to the relationship between context and life scenarios. Thus each designer while dealing with a main functional program simultaneously deals with various issues such as the rationalization of the road system the redevelopment of existing buildings the design and refunctionalization of urban services (for example the transformed Central Station in the hotel or the project of a great Mosque)several degree theses have addressed as the main theme or as a question in the background the design of a new bed for the Oreto river and the relative establishment of a park facing it. In this desire to "patch up the wounds" in the different areas of "Palermo South-East" in close relationship with the vicissitudes of the place there is a continuous reference to architectures of all time and some questions involving the functional program are suggested - that identifies the character (or perhaps "type") of what is to be inserted in a given context - and the qualities of living reality as a pivotal material in the design process.Settore ICAR/14 - Composizione Architettonica E Urbana
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Thyroid dysfunction in pediatric patients with mild-moderate chronic renal insufficiency

2010

ThyroidSettore MED/38 - Pediatria Generale E Specialisticachronic renal insufficiency
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Persistent episomal transgene expression in liver following delivery of a scaffold/matrix attachment region containing non-viral vector

2008

An ideal gene therapy vector should enable persistent transgene expression without limitations of safety and reproducibility. Here we report the development of a non-viral episomal plasmid DNA (pDNA) vector that appears to fulfil these criteria. This pDNA vector combines a scaffold/matrix attachment region (S/MAR) with a human liver-specific promoter (alpha1-antitrypsin (AAT)) in such a way that long-term expression is enabled in murine liver following hydrodynamic injection. Long-term expression is demonstrated by monitoring the longitudinal luciferase expression profile for up to 6 months by means of in situ bioluminescent imaging. All relevant control pDNA constructs expressing luciferas…

Time FactorsTransgeneGenetic VectorsGene ExpressionMice Inbred StrainsGene deliveryBiologyTransfectionViral vectorInjectionsMiceSettore MED/38 - Pediatria Generale E SpecialisticaGene expressionGeneticsGene silencingAnimalsHepatectomyHumansLuciferaseTransgenesScaffold/matrix attachment regionLuciferasesPromoter Regions GeneticMolecular BiologyGenetic Therapynon-viral episomal plasmid DNA (pDNA) vector S/MAR element hydrodynamic injection.DNA MethylationMatrix Attachment RegionsMolecular biologyImmunohistochemistryLiveralpha 1-AntitrypsinDNA methylationMolecular MedicinePlasmids
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Percezione della necessità di svolgere tirocini formativi in ambito internazionale (International Health Electives) tra i medici in formazione specia…

2013

Introduzione Nell’attuale scenario mondiale, ricevere una formazione in salute globale (global health) e poter intraprendere una esperienza formativa in ambito internazionale (International Health Elective, IHE) rappresentano validi strumenti per migliorare il percorso educativo della futura classe medica. Pochi studi hanno valutato l’impatto che una IHE può esercitare nei confronti dei medici in formazione specialistica. Considerato che in Italia è stato riscontrato un interesse crescente nei confronti degli IHE, lo scopo dello studio è stato quello di analizzare i dati relativi alla percezione della necessità di svolgere esperienze formative internazionali in un campione di medici in form…

Tirocini professionalizzanti medici in formazione specialisticaSettore MED/42 - Igiene Generale E Applicata
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Development of S/MAR minicircles for enhanced and persistent transgene expression in the mouse liver.

2010

We have previously described the development of a scaffold/matrix attachment region (S/MAR) episomal vector system for in vivo application and demonstrated its utility to sustain transgene expression in the mouse liver for at least 6 months following a single administration. Subsequently, we observed that transgene expression is sustained for the lifetime of the animal. The level of expression, however, does drop appreciably over time. We hypothesised that by eliminating the bacterial components in our vectors, we could improve their performance since bacterial sequences have been shown to be responsible for the immunotoxicity of the vector and the silencing of its expression when applied i…

TransgeneGenetic VectorsEnzyme-Linked Immunosorbent AssayBiologyMinicircleMolecular biologyPolymerase Chain ReactionScaffold/matrix attachment region (S/MAR) – Minicircle – Plasmid – Non-viral – Gene therapy – Liver – Hydrodynamic deliveryBlotting SouthernMicePlasmidSettore MED/38 - Pediatria Generale E SpecialisticaLiverIn vivoCell Line TumorDrug DiscoveryGene expressionMolecular MedicineGene silencingAnimalsHumansExpression cassetteTransgenesScaffold/matrix attachment regionGenetics (clinical)Journal of molecular medicine (Berlin, Germany)
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MTHFR C677T homozygous as risk factor for complications after OLT for cryptogenic cirrhosis

2006

TransplantationPediatricsmedicine.medical_specialtySettore MED/38 - Pediatria Generale E Specialisticabusiness.industryMTHFR C677T OLT Cryptogenic cirrhosis.Cryptogenic cirrhosisMthfr c677tMedicineRisk factorbusinessClinical Transplantation
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Life-history trade-offs in a generalist digenean from cetaceans: the role of host specificity and environmental factors

2015

Background Adults and larvae of generalist parasites are exposed to diverse hosts and local environmental conditions throughout their life cycles, thus local adaptation is expected to occur through phenotypic plasticity and/or natural selection. We investigated how the combined effect of cryptic host specificity and local selective pressures could shape reproductive traits of a putative generalist parasite in the oceanic realm. Methods The LSU rDNA, ITS2 and the mt-COI of individuals of the digenean Pholeter gastrophilus (Kossack, 1910) Odhner, 1914 (Heterophyidae Leiper, 1909) from oceanic striped dolphins, Stenella coeruleoalba Meyen, and coastal bottlenose dolphins, Tursiops truncatus Mo…

TroglotrematidaeZygoteMolecular Sequence DataZoologyTrade-offStenella coeruleoalbaBiologyGeneralist and specialist speciesDNA RibosomalHost SpecificityElectron Transport Complex IVStenellabiology.animalDNA Ribosomal Spacerparasitic diseasesMediterranean SeaAnimalsLocal adaptationPhenotypic plasticityHost (biology)EcologyResearchEgg sizefungiIntermediate hostEnvironmental exposureEnvironmental ExposureSequence Analysis DNADNA HelminthStenellaAdaptation PhysiologicalBottle-Nosed DolphinInfectious DiseasesFecundityRNA Ribosomalembryonic structuresParasitologyhuman activitiesDigeneaParasites & Vectors
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TROMBOSI VENOSA PROFONDA DA ESTROPROGESTINICI IN TETRASOMIA X

2009

Trombosi venosa profonda Tetrasomia X EstroprogestiniciSettore MED/38 - Pediatria Generale E Specialistica
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TERATOMA IMMATURO EXTRACRANICO: Risultati dello Studio Cooperativo AIEOP "TCG-91".

1998

I Teratomi Immatuti sono tumori costituiti da tessuto non maligno ma con potenzialità evolutiva maligna. Gli Autori presentano i dati dello Studio Cooperativo "TCG-91".

Tumori Germinali Pediatrici Teratomi ImmaturiSettore MED/38 - Pediatria Generale E SpecialisticaSettore MED/20 - Chirurgia Pediatrica E Infantile
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YOLK SAC DEL TESTICOLO: Raro Caso con Metastasi Gigante Retroperitoneale

1989

The authors restorate a case of primary testis tumor (Yolk Sac Tumor) and giant retroperitoneal metastasis clinically evident as a voluminous abdominal mass (23 cm) and associated virilizing syndrome. the diagnostic and therapeutic procedure performed is described.

Tumori GerminaliSettore MED/38 - Pediatria Generale E SpecialisticaYolk Sac del testicoloSettore MED/20 - Chirurgia Pediatrica E InfantileTumori in età pediatricaSettore MED/13 - Endocrinologia
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