Search results for " Specialized"
showing 10 items of 190 documents
Mechanisms of C-reactive protein-induced blood-brain barrier disruption.
2009
Background and Purpose— Increased mortality after stroke is associated with brain edema formation and high plasma levels of the acute phase reactant C-reactive protein (CRP). The aim of this study was to examine whether CRP directly affects blood–brain barrier stability and to analyze the underlying signaling pathways. Methods— We used a cell coculture model of the blood–brain barrier and the guinea pig isolated whole brain preparation. Results— We could show that CRP at clinically relevant concentrations (10 to 20 μg/mL) causes a disruption of the blood–brain barrier in both approaches. The results of our study further demonstrate CRP-induced activation of surface Fcγ receptors CD16/32 fo…
Transitions between care settings after enrollment in a palliative care service in Italy: a retrospective analysis.
2013
This study was a retrospective analysis of prospectively collected data that aimed to map patients’ care transitions following admission to a specialist palliative care service in Italy called Antea Centre. Patients’ data was extracted from the Antea local database from 2007 to 2011. External transitions were defined as a change in the setting of care, with the patient no longer being cared for by Antea staff. Internal transitions were defined as a change in the setting of care, with the care still being provided by Antea staff. A total of 1123 patients out of 5313 admitted to the palliative service (21%) experienced transitions. Patients who experienced no transitions after their admissio…
Cerebral protection against ischemia by locomotor activity in gerbils. Underlying mechanisms.
1995
Background and Purpose A previous communication of this laboratory demonstrated reduced mortality and neuronal damage by spontaneous locomotor activity preceding forebrain ischemia in Mongolian gerbils. The present experiments seek to elucidate potential mechanisms of protection by measurement of cerebral blood flow, cerebral tissue conductance as an indicator of ischemic cell swelling, and the cerebral release of eicosanoids. Methods Gerbils were maintained either in conventional cages (nonrunners) or with free access to running wheels (runners) for 2 weeks preceding 15 minutes of forebrain ischemia. During ischemia and 2.5 hours of reperfusion, cerebral tissue conductance was determined …
Lipoic Acid Improves Nerve Blood Flow, Reduces Oxidative Stress, and Improves Distal Nerve Conduction in Experimental Diabetic Neuropathy
1995
OBJECTIVE To determine whether lipoic acid (LA) will reduce oxidative stress in diabetic peripheral nerves and improve neuropathy. RESEARCH DESIGN AND METHODS We used the model of streptozotocin-induced diabetic neuropathy (SDN) and evaluated the efficacy of LA supplementation in improving nerve blood flow (NBF), electrophysiology, and indexes of oxidative stress in peripheral nerves affected by SDN, at 1 month after onset of diabetes and in age-matched control rats. LA, in doses of 20, 50, and 100 mg/kg, was administered intraperitoneally five times per week after onset of diabetes. RESULTS NBF in SDN was reduced by 50% LA did not affect the NBF of normal nerves but improved that of SDN i…
Meta-analysis of the efficacy of different training strategies in animal models of ischemic stroke.
2013
Background and Purpose— Although several studies have shown beneficial effects of training in animal stroke models, the most effective training strategy and the optimal time to initiate training have not been identified. The present meta-analysis was performed to compare the efficacy of different training strategies and to determine the optimal time window for training in animal stroke models. Methods— We searched the literature for studies analyzing the efficacy of training in animal models of ischemic stroke. Training was categorized into forced physical training, voluntary physical training, constraint-induced movement therapy, and skilled reaching training. Two reviewers independently …
Letter by Barco et al Regarding Article, "Restarting Anticoagulant Therapy After Intracranial Hemorrhage: A Systematic Review and Meta-Analysis"
2017
We read with interest the systematic review and meta-analysis authored by Murthy et al1 that appeared in Stroke . The authors studied the efficacy and safety of anticoagulant resumption after nontraumatic intracranial hemorrhage (ICH) and showed that resumption was associated with a lower risk of arterial thromboembolism but a similar risk of recurrent ICH. We do have some comments on their interpretation of the results. First, all the included studies had a retrospective design and, therefore, are characterized by heterogeneity in treatment regimens and timing of anticoagulation restart. As the authors argue in their discussion, location matters for the risk of recurrent ICH: lobar bleedin…
Calques and Loanwords from English in Italian Specialized Press. An Investigation on the Names of Sports.
2008
Within specialized discourse in the Italian language sports journalism communication is certainly one of the richest in anglicisms. This study investigates the influence of English on Italian sports newspaper lexicon with particular reference to the denominations of sports disciplines which are loanwords and calques from English. The corpus studied is made up of the three main Italian sports dailies - “La Gazzetta dello Sport”, the “Corriere dello Sport” and “Tuttosport” - which have been observed in their on line version through the second sixth-month period of 2006. The attention will be focused on the terminological aspects of Italian sports language with respect to: types of borrowings …
PRODUZIONE DI RIFIUTI A RISCHIO INFETTIVO E INDICI DI COMPLESSITÀ IN UN “CENTRO TRAPIANTI”
2015
Questo studio analizza la produzione di rifiuti a rischio infettivo in una grande struttura ospedaliera specializzata per le attività di trapianto: Ismett (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), che si trova a Palermo. Sono state determinate le relazioni fra la quantità e la composizione dei rifiuti, da una parte; la complessità della struttura e la natura delle cure erogate, dall’altra. In letteratura si trovano regolarmente i risultati di ricerche sulla produzione di rifiuti a rischio infettivo nei più diversi Paesi del mondo; i dati pubblicati provengono quasi esclusivamente da Ospedali Generali, anche complessi e di Alta Specializzazione. Tali dati po…
A Changing Media Landscape. Science, the Public and the Press: The Case of Climate Change
2013
Economic restructuring in the media industry has eliminated many professional journalists’ jobs, reductions that may have been hardest on specialized journalists reporting areas like science, technology, economics, or international affairs. This makes audiences even more dependent on new, often social, media for scientific information. The concept of «critical science literacy» is introduced as a way to capture the skills needed to navigate science news in the evolving media landscape. While these same skills were needed to make sense of science in the «old» media world as well, the contemporary shift resulting in attenuation of authoritative journalistic voices is likely to continue, deman…
Speciālo izmeklēšanas darbību aktuālie problēmjautājumi
2016
Maģistra darbs sniedz padziļinātu ieskatu speciālo izmeklēšanas darbību kā kriminālprocesuāla institūta problēmjautājumos, kuru pamatā lielākoties ir tieši teorijā un praksē nostiprinājušos atziņu dažādība. Darbs sastāv no trim galvenajām nodaļām, kurās autore apzina un analizē speciālo izmeklēšanas darbību teorētiskos un praktiskos aspektus un no to atšķirīgās normatīvā regulējuma interpretācijas izrietošos tādus aktuālos problēmjautājumus kā saistība ar operatīvās darbības pasākumiem, ar šīm darbībām saistīto procesuālo dokumentu un darbību veicēju liecību nozīme pierādīšanā, iegūtās informācijas aizsardzība u.c. Darba rezultātā autore konstatē pretrunas tiesību normu piemērošanā un ieros…