Search results for " Spheroid"

Phake Intraokularlinsen

2004

Phakic intraocular lenses (PIOLs), which are located closer to the eye's nodal points than the anterior corneal surface, can provide superior optical quality for higher corrections because of retention of normal prolate corneal asphericity and larger effective optical zones. Improvements in the material and design of phakic intraocular lenses and their insertion devices combined with advances in the understanding of the anatomical and physiological interactions of the PIOLs with intraocular structures, have increased safety and efficacy. Safety of these implants over the long term remains a concern, but in several situations PIOLs are the refractive correction of choice. The purpose of this…

Hydrogel scaffolds blends to host Spheroids from human adipose stem cells

INTRODUCTION Adipose stem cells represent a reliable source of stem cells for their widely demonstrated potential in regenerative medicine and tissue engineering applications. New recent insights show that 3D models may properly mimic the native tissue properties; in fact Spheroids from Adipose derived Stem Cells (S-ASCs) displayed enhanced regenerative abilities if compared to 2D models. Stem cell therapy success is determined by "cell-quality" thus the involvement of stress signals and cellular aging need to be deeply investigated. The development of 3D cell-laden hydrogels has enabled to mimic the peculiar scenario of a native tissue. We studied SASCs-cell quality and tested their viabil…

Smart hydrogels with Spheroids of Adipose stem cells for minimally invasive bone and cartilage regeneration

2022

Oxygenation Status of Rhabdomyosarcoma Spheroids with Different Stages of Differentiation

1994

Multicellular tumor spheroids with regional heterogeneities of proliferation and substrate concentrations have been investigated recently to study the biological properties of small tumor nodules prior to onset of vascularization (for reviews see: Mueller-Klieser, 1987; Sutherland, 1988).

Sur la fonction des « sphéroïdes » en tôle de l’Age du bronze

2013

La fonction des quatre sphéroïdes en tôle de bronze de France et de Suisse connus, souvent décrits, n’a jamais été établie. En raison de leur mode de façonnage, de leur technique de montage et du style de leur décoration, ils sont rapprochés ici des sphéroïdes italiens qui sont généralement complets. Ces derniers, découverts en général dans des sépultures, étant interprétés comme des encensoirs, il est proposé de considérer comme tels, avec des réserves du fait de leur état fragmentaire, les exemplaires de France et de Suisse. Ces récipients, datés en France du Bronze final IIIb, connaissent en Italie une évolution qui se prolonge jusqu’au début du VIIe s. av. J.-C. Although the four known …

Glucose Diffusion Coefficients Determined from Concentration Profiles in Emt6 Tumor Spheroids Incubated in Radioactively Labeled L-Glucose

1994

In order to theoretically assess tissue energetic status, conditions for substance exchange need to be known. One group of parameters important in this context are diffusion coefficients of nutrients and metabolic waste products which may be assessed by incubating spheroids in a medium containing tracer amounts of the radioactively labeled substance in question, for a defined period of time. In previous studies, the overall amount of 14C-labeled substance taken up by the spheroids was measured by scintillation counters (e.g.[1]), or the concentration of 3H-labeled substance in the spheroid center was determined by autoradiography and grain counting (e.g. [4]). From a number of such measurem…

Development of an in vitro neuroblastoma 3D model and its application for sterigmatocystin-induced cytotoxicity testing

2021

Abstract Given the increasing importance of establishing better risk assessments for mycotoxins, novel in vitro tools for the evaluation of their toxicity are mandatory. In this study, an in vitro 3D spheroid model from SH-SY5Y cells, a human neuroblastoma cell line, was developed, optimized and characterized to test the cytotoxic effects caused by the mycotoxin sterigmatocystin (STE). STE induced a concentration- and time-dependent cell viability decrease in spheroids. Spheroids displayed cell disaggregation after STE exposure, increasing in a dose-dependent manner and over time. STE also induced apoptosis as confirmed by immunofluorescence staining and Western blot. Following the decrease…

Fast Computation by Subdivision of Multidimensional Splines and Their Applications

2016

We present theory and algorithms for fast explicit computations of uni- and multi-dimensional periodic splines of arbitrary order at triadic rational points and of splines of even order at diadic rational points. The algorithms use the forward and the inverse Fast Fourier transform (FFT). The implementation is as fast as FFT computation. The algorithms are based on binary and ternary subdivision of splines. Interpolating and smoothing splines are used for a sample rate convertor such as resolution upsampling of discrete-time signals and digital images and restoration of decimated images that were contaminated by noise. The performance of the rate conversion based spline is compared with the…

Alginate encapsulation improves viability and integrity of cryopreserved pancreatic islets and multicellular spheroids: combined fluorescence, scanni…

2007

Extended abstract of a paper presented at MC 2007, 33rd DGE Conference in Saarbrücken, Germany, September 2 – September 7, 2007