Search results for " Stab"
showing 10 items of 1773 documents
Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid.
2012
A biowaiver monograph for acetylsalicylic acid (ASA) is presented. Literature and experimental data indicate that ASA is a highly soluble and highly permeable drug, leading to assignment of this active pharmaceutical ingredient (API) to Class I of the Biopharmaceutics Classification System (BCS). Limited bioequivalence (BE) studies reported in the literature indicate that products that have been tested are bioequivalent. Most of the excipients used in products with a marketing authorization in Europe are not considered to have an impact on gastrointestinal motility or permeability. Furthermore, ASA has a wide therapeutic index. Thus, the risks to the patient that might occur if a nonbioequi…
Robust H∞ reliable control for delta operator switched systems with time-varying delays under asynchronous switching
2014
The problem of robust H∞ reliable control for a class of delta operator switched systems with time-varying delays and actuator faults under asynchronous switching is considered in this paper. Asynchronous switching means that the switches between the candidate controllers and system modes are asynchronous. Based on the average dwell time approach and delta operator theory, a state feedback controller is designed such that the closed-loop system is exponentially stable with H∞ performance in the presence of actuator faults. The obtained results are formulated in the form of linear matrix inequalities (LMIs). Finally, a numerical example is provided to demonstrate explicitly the feasibility …
Stability and -Gain Control of Positive Switched Systems with Time-Varying Delays via Delta Operator Approach
2013
This paper investigates the problems of stability and -gain controller design for positive switched systems with time-varying delays via delta operator approach. The purpose is to design a switching signal and a state feedback controller such that the resulting closed-loop system is exponentially stable with -gain performance. Based on the average dwell time approach, a sufficient condition for the existence of an -gain controller for the considered system is established by constructing an appropriate copositive type Lyapunov-Krasovskii functional in delta domain. Moreover, the obtained conditions can unify some previously suggested relevant methods in the literature of both continuous- and…
A state-space approach to dynamic stability of fractional-order systems: The extended Routh-Hurwitz theorem
2017
This paper considers the case of Beck’s column, a linear elastic cantilever column subjected to a constant follower load at its free end. The column foundation is modeled as bed of hereditary elements that react with a vertical force distributed along the beam axis. The reacting supports are modeled with spring-pot element that is a two parameters mechanical elements (C; ) with an intermediate behavior between spring and dashpot. The constitutive equation of the spring-pot involves the so called fractional order derivatives and dynamic stability problem in presence of fractional-order operator must be faced for the Beck’s column. In this study , the authors generalize Routh-Hurwitz theorem …
Comparative Study of the Mechanical Unfolding Pathways of α- and β-Peptides
2015
Using molecular simulations, we analyze the unfolding pathways of various peptides. We compare the mechanical unfolding of a β-alanine's octamer (β-HAla8) and an α-alanine's decamer (α-Ala10). Using force-probe molecular-dynamics simulations, to induce unfolding, we show that the 3(14)-helix formed by β-HAla8 is mechanically more stable than the α-helix formed by α-Ala10, although both structures are stabilized by six hydrogen bonds. Additionally, computations of the potential of mean force validate this result and show that also the thermal stability of the 3(14)-helix is higher. It is demonstrated that β-HAla8 unfolds in a two-step fashion with a stable intermediate. This is contrasted wi…
Resistant Microbial Cooccurrence Patterns Inferred by Network Topology
2015
ABSTRACT Although complex cooccurrence patterns have been described for microbes in natural communities, these patterns have scarcely been interpreted in the context of ecosystem functioning and stability. Here we constructed networks from species cooccurrences between pairs of microorganisms which were extracted from five individual aquatic time series, including a dystrophic and a eutrophic lake as well as an open ocean site. The resulting networks exhibited higher clustering coefficients, shorter path lengths, and higher average node degrees and levels of betweenness than those of random networks. Moreover, simulations demonstrated that taxa with a large number of cooccurrences and place…
Revisiting the role of top-down and bottom-up controls in stabilisation of nutrient-rich plankton communities
2019
Understanding the conditions for successful control of phytoplankton by zooplankton in eutrophic ecosystems is a highly important research area with a wide implementation of mathematical modelling. Theoretical models generally predict destabilisation of food webs in eutrophic environments with large-amplitude oscillations of population densities which would eventually result in species extinction. On the other hand, these theoretical predic- tions are often at odds with ecological observations demonstrating stable dynamics even for a high nutrient load. This apparent discrepancy is known in the literature as Rosen- zweig’s “paradox of enrichment”. Recent theoretical works emphasize a crucia…
Genomic signatures of recent adaptation in a wild bumblebee
2021
AbstractBehavioral experiments and analyses of observation records have shown that environmental changes threaten insect pollinators, creating risks for agriculture and ecosystem stability. Despite their importance, we know little about how wild insects or other animals can adapt in response to environmental pressures. To understand the genomic bases of adaptation in an ecologically important pollinator, we analyzed genomes ofBombus terrestrisbumblebees collected across Great Britain. We reveal extensive genetic diversity within this population, and strong signatures of recent adaptation throughout the genome. More specifically, we find that selection recently affected key processes underpi…
An Ecology and Economy Coupling Model. A global stationary state model for a sustainable economy in the Hamiltonian formalism
2020
Abstract The severity of the two deeply correlated crises, the environmental and the economic ones, needs to be faced also in theoretical terms; thus, the authors propose a model yielding a global “stationary state”, following the idea of a “steady-state economics” by Georgescu-Rogen and Herman Daly, by constructing only one dynamical system of ecological and economic coupled variables. This is possible resorting to the generalized Volterra model, that, translated in the Hamiltonian formalism and its Hamilton equations, makes possible to “conjugate” every pair of variables, one economic, the other one ecological, in describing the behavior in time of a unique dynamical system. Applying the …
Bank fragility and contagion: Evidence from the bank CDS market
2016
Understanding how contagion works among financial institutions is a top priority for regulators and policy makers who aim to foster financial stability and to prevent financial crises. Using bank credit default swap (CDS) data, we provide a framework for the evaluation of contagion among banks in different countries and regions during a period of prolonged financial distress. We measure contagion in terms of return spillovers, following a Generalized VAR (GVAR) approach. In addition, we propose an innovative framework to distinguish between two types of contagion: systematic (linked to global factors), and idiosyncratic (linked to bank specific factors). We find evidence of both types of co…