Search results for " Statistical"
showing 10 items of 1649 documents
Sparse relative risk regression models
2020
Summary Clinical studies where patients are routinely screened for many genomic features are becoming more routine. In principle, this holds the promise of being able to find genomic signatures for a particular disease. In particular, cancer survival is thought to be closely linked to the genomic constitution of the tumor. Discovering such signatures will be useful in the diagnosis of the patient, may be used for treatment decisions and, perhaps, even the development of new treatments. However, genomic data are typically noisy and high-dimensional, not rarely outstripping the number of patients included in the study. Regularized survival models have been proposed to deal with such scenarios…
An interest rates cluster analysis
2004
An empirical analysis of interest rates in money and capital markets is performed. We investigate a set of 34 different weekly interest rate time series during a time period of 16 years between 1982 and 1997. Our study is focused on the collective behavior of the stochastic fluctuations of these time-series which is investigated by using a clustering linkage procedure. Without any a priori assumption, we individuate a meaningful separation in 6 main clusters organized in a hierarchical structure.
Entropic descriptor of a complex behaviour
2009
We propose a new type of entropic descriptor that is able to quantify the statistical complexity (a measure of complex behaviour) by taking simultaneously into account the average departures of a system's entropy S from both its maximum possible value Smax and its minimum possible value Smin. When these two departures are similar to each other, the statistical complexity is maximal. We apply the new concept to the variability, over a range of length scales, of spatial or grey-level pattern arrangements in simple models. The pertinent results confirm the fact that a highly non-trivial, length-scale dependence of the entropic descriptor makes it an adequate complexity-measure, able to disting…
A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies
2011
The aim of the present work was to develop a new mathematical method for estimating the area under the curve (AUC) and its variability that could be applied in different preclinical experimental designs and amenable to be implemented in standard calculation worksheets. In order to assess the usefulness of the new approach, different experimental scenarios were studied and the results were compared with those obtained with commonly used software: WinNonlin® and Phoenix WinNonlin®. The results do not show statistical differences among the AUC values obtained by both procedures, but the new method appears to be a better estimator of the AUC standard error, measured as the coverage of 95% confi…
Anthropometry: An R Package for Analysis of Anthropometric Data
2017
The development of powerful new 3D scanning techniques has enabled the generation of large up-to-date anthropometric databases which provide highly valued data to improve the ergonomic design of products adapted to the user population. As a consequence, Ergonomics and Anthropometry are two increasingly quantitative fields, so advanced statistical methodologies and modern software tools are required to get the maximum benefit from anthropometric data. This paper presents a new R package, called Anthropometry, which is available on the Comprehensive R Archive Network. It brings together some statistical methodologies concerning clustering, statistical shape analysis, statistical archetypal an…
The angle of repose of spherical grains in granular Hele-Shaw cells: A molecular dynamics study
2007
We report the results of three dimensional molecular dynamic simulations on the angle of repose of a sandpile formed by pouring mono-sized cohesionless spherical grains into a granular Hele-Shaw cell. In particular, we are interested to investigate the effects of those variables which may impact significantly on pattern formation of granular mixtures in Hele-Shaw cells. The results indicate that the frictional forces influence remarkably the formation of pile on the grain level. Furthermore, We see that increasing grain insertion rate decreases slightly the angle of repose. We also find that in accordance with experimental results, the cell thickness is another significant factor and the an…
Extended quasi-additivity of Tsallis entropies
2006
We consider statistically independent non-identical subsystems with different entropic indices q1 and q2. A relation between q1, q2 and q' (for the entire system) extends a power law for entropic index as a function of distance r. A few examples illustrate a role of the proposed constraint q' < min(q1, q2) for the Beck's concept of quasi-additivity.
Pandemetrics: systematically assessing, monitoring, and controlling the evolution of a pandemic
2022
AbstractThe still ongoing pandemic of SARS-CoV-2 virus and COVID-19 disease, affecting the population worldwide, has demonstrated the need of more accurate methodologies for assessing, monitoring, and controlling an outbreak of such devastating proportions. Authoritative attempts have been made in traditional fields of medicine (epidemiology, virology, infectiology) to address these shortcomings, mainly by relying on mathematical and statistical modeling. However, here, we propose approaching the methodological work from a different, and to some extent alternative, standpoint. Applied systematically, the concepts and tools of statistical engineering and quality management, developed not onl…
Statistical inference and Monte Carlo algorithms
1996
This review article looks at a small part of the picture of the interrelationship between statistical theory and computational algorithms, especially the Gibbs sampler and the Accept-Reject algorithm. We pay particular attention to how the methodologies affect and complement each other.
Modeling temperature effects on mortality: multiple segmented relationships with common break points.
2008
We present a model for estimation of temperature effects on mortality that is able to capture jointly the typical features of every temperature-death relationship, that is, nonlinearity and delayed effect of cold and heat over a few days. Using a segmented approximation along with a doubly penalized spline-based distributed lag parameterization, estimates and relevant standard errors of the cold- and heat-related risks and the heat tolerance are provided. The model is applied to data from Milano, Italy.