Search results for " Strategy"
showing 10 items of 764 documents
Una strategia nazionale a difesa del Cyberspazio
2023
L’articolo intende proporre un’analisi circa lo stato dell’arte della sicurezza ci- bernetica in Italia, prestando particolare attenzione alle principali novità conte- nute all’interno della Strategia Nazionale di Cybersicurezza 2022-2026. Nello specifico, dopo aver offerto un inquadramento giuridico del fenomeno degli at- tacchi informatici, il contributo intende approfondire con una visione critica le future sfide che vedranno l’Italia e l’Europa protagoniste nella difesa del pro- prio “dominio cibernetico”. The article intends to propose an analysis about the state of the art of cyber security in Italy, paying particular attention to the main innovations contained in the National Cyberse…
Inhalable nano into micro dry powders for ivacaftor delivery: The role of mannitol and cysteamine as mucus-active agents.
2020
In this paper the innovative approach of Nano into micro (NiM9 was developed to produce Nanoparticles loaded Ivacaftor to incorporate into mannitol or mannitol/cysteamine micromatrices for drug pulmonary administration in CF. Nanoparticles composed by a mixture of two polyhydrohydroxyethtylaspartamide copolymers containing a loading of Ivacaftor of 15.5 % w/w were produced. These Nanoparticles were incorporated into microparticles to obtain NiM that were characterized in terms of size and size distribution, interaction with CF-AM by rheological and turbidimetric studies as well as by aerodynamic diameter measurements. Finally the activity of Ivacaftor into these NiM was evaluated by in vitr…
Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010–present)
2021
Introduction: DNA-dependent protein kinase (DNA-PK) plays a crucial role in the repair of DSBs via non-homologous end joining (NHEJ). Several DNA-PK inhibitors are being investigated for potential anticancer treatment in clinical trials.Area covered: This review aims to give an overview of patents published since 2010 by analyzing the patent space and structure features of scaffolds used in those patents. It also discusses the recent clinical developments and provides perspectives on future challenges and directions in this field.Expert opinion: As a key component of the DNA damage response (DDR) pathway, DNA-PK appears to be a viable drug target for anticancer therapy. The clinical investi…
SUP R DSS: A sustainability-based decision support & system for road pavements
2019
Road pavement community members are increasingly becoming aware of the need to incorporating the principles of sustainable development into the sector. Policies are also going in this direction and as a consequence in the recent years researchers and practitioners are coming up with new materials, technologies and practices designed to reduce the negative impacts of their activities in the surroundings. Within this framework the road pavements sector is witnessing a paradigm shift towards the development of pavement technologies incorporating high-content of recycled materials, as well as best practices to decrease the overall carbon footprint. These are all promising solutions that to the …
New dispatching strategy for the integration of active-demand and distributed storage in the electricity market
2015
The proliferation of Distributed Generation (DG) in power systems calls for a redesign of electricity network management, which should be able to accommodate large amounts of intermittent generation. This issue requires a discussion about the current dispatching regulation, giving distributed storage systems and qualified electricity consumption the opportunity to provide ancillary services to the distribution grid. In this work, a new dispatching strategy for the integration of active-demand and distributed storage in the Italian electricity market is presented. The strategy is focused on a distribution Smart Grid (SG), where customers can indirectly participate to the Day-Ahead (DA) and t…
Investment in Design and Firm Performance: The Mediating Role of Design Management
2009
Design management is an increasingly important concept, research into which is remarkably scarce. Although the literature suggests that design management has an effect on design effectiveness, there is no empirical support for the impact of design management on firm performance. Furthermore, few studies have quantified the contribution that design makes to company performance. The aim of this paper is to analyze the effect of design investment on company performance and how this relationship is mediated by design management skills. Structural equation modeling was used to test the research hypotheses on a data set from the Italian and Spanish ceramic tile industry. Results suggest, first, t…
El Máster en Profesorado de Secundaria desde dentro: expectativas y realidades del Prácticum
2016
El objetivo principal que se plantea este trabajo es analizar las prácticas externas en la formación del profesorado de Educación Secundaria desde el punto de vista del discente en prácticas, aportando argumentos para la autocrítica y dando voz a los verdaderos protagonistas del máster, su alumnado. Hemos utilizado como herramienta metodológica los grupos de discusión, optando por la elaboración de resultados y conclusiones como estrategia descriptiva-clasificatoria-interpretativa, donde se aportan soluciones y propuestas de mejora, fruto de la reflexión compartida. Se han analizado entre otros aspectos teoría versus práctica, metodologías de enseñanza-aprendizaje, percepción previa de los…
The contribution of geographical certification programs to farm income and rural economies: The case of Pecorino Siciliano PDO
2021
This study attempts to measure the capacity of the EU geographical certification scheme to positively influence the price of certified products and the incomes of their producers. A comparison of the economic results of two cheese-producing dairy farm enterprises with different business strategies and locations within the Sicilian hinterlands is performed in order to determine the transformation value of each dairy’s sheep milk into pecorino cheese (with and without the Protected Designation of Origin, or PDO, certification) and the related joint products (ricotta). The economic convenience of the total transformation of sheep milk into Pecorino Siciliano PDO and ricotta is also appraised. …
Diffraction by m-bonacci gratings
2015
We present a simple diffraction experiment with m-bonacci gratings as a new interesting generalization of the Fibonacci ones. Diffraction by these nonconventional structures is proposed as a motivational strategy to introduce students to basic research activities. The Fraunhofer diffraction patterns are obtained with the standard equipment present in most undergraduate physics labs and are compared with those obtained with regular periodic gratings. We show that m-bonacci gratings produce discrete Fraunhofer patterns characterized by a set of diffraction peaks which positions are related to the concept of a generalized golden mean. A very good agreement is obtained between experimental and …
Hyperreal positioning and cross-channel strategy of cultural sites: towards the construction of a metaexperience for the visitor?
2019
International audience; Immersive concepts, games, participation, digitization ... many concepts that cultural institutions adopt to enlarge their audiences. Through these tools, reality, imagination and simulation, are mixing to give rise to a hyperreal offer. With the development of digital and multiple consumption behaviors, the analysis of the coherence between physical and digital channels is now a major challenge for museums. Based on 16 French museums case studies, this research proposes some solutions to the articulation of these channels in order to propose a coherent global experience.