Search results for " TAU"
showing 10 items of 636 documents
Risk-reducing hysterectomy and bilateral salpingo-oophorectomy in female heterozygotes of pathogenic mismatch repair variants: a Prospective Lynch Sy…
2021
Abstract Purpose To determine impact of risk-reducing hysterectomy and bilateral salpingo-oophorectomy (BSO) on gynecological cancer incidence and death in heterozygotes of pathogenic MMR ( path_MMR ) variants. Methods The Prospective Lynch Syndrome Database was used to investigate the effects of gynecological risk-reducing surgery (RRS) at different ages. Results Risk-reducing hysterectomy at 25 years of age prevents endometrial cancer before 50 years in 15%, 18%, 13%, and 0% of path_MLH1 , path_MSH2 , path_MSH6 , and path_PMS2 heterozygotes and death in 2%, 2%, 1%, and 0%, respectively. Risk-reducing BSO at 25 years of age prevents ovarian cancer before 50 years in 6%, 11%, 2%, and 0% and…
Modulating disease-relevant tau oligomeric strains by small molecules
2020
The pathological aggregation of tau plays an important role in Alzheimer's disease and many other related neurodegenerative diseases, collectively referred to as tauopathies. Recent evidence has demonstrated that tau oligomers, small and soluble prefibrillar aggregates, are highly toxic due to their strong ability to seed tau misfolding and propagate the pathology seen across different neurodegenerative diseases. We previously showed that novel curcumin derivatives affect preformed tau oligomer aggregation pathways by promoting the formation of more aggregated and nontoxic tau aggregates. To further investigate their therapeutic potential, we have extended our studies o disease-relevant bra…
Effects of a home-based rehabilitation program in community-dwelling older people after discharge from hospital: A subgroup analysis of a randomized …
2021
Objective: To examine whether pre-admission community mobility explains the effects of a rehabilitation program on physical performance and activity in older adults recently discharged from hospital. Design: A secondary analysis of a randomized controlled trial. Setting: Home and community. Participants: Community-dwelling adults aged ⩾60 years recovering from a lower limb or back injury, surgery or other disorder who were randomized to a rehabilitation ( n = 59) or standard care control ( n = 58) group. They were further classified into subgroups that were not planned a priori: (1) mild, (2) moderate, or (3) severe pre-admission restrictions in community mobility. Interventions: The 6-mont…
Serological Follow-Up Study Indicates High Seasonal Coronavirus Infection and Reinfection Rates in Early Childhood
2022
Seasonal human coronaviruses (HCoVs) cause respiratory infections, especially in children. Currently, the knowledge on early childhood seasonal coronavirus infections and the duration of antibody levels following the first infections is limited. Here we analyzed serological follow-up samples to estimate the rate of primary infection and reinfection(s) caused by seasonal coronaviruses in early childhood. Serum specimens were collected from 140 children at ages of 13, 24, and 36 months (1, 2, and 3 years), and IgG antibody levels against recombinant HCoV nucleoproteins (N) were measured by enzyme immunoassay (EIA). Altogether, 84% (118/140) of the children were seropositive for at least one s…
"Table 4" of "Search for heavy Higgs bosons decaying into two tau leptons with the ATLAS detector using $pp$ collisions at $\sqrt{s}=13$ TeV"
2020
Observed and predicted mTtot distribution in the b-tag category of the 2tau_h channel. Please note that the bin content is divided by the bin width in the paper figure, but not in the HepData table. The last bin includes overflows. The combined prediction for A and H bosons with masses of 400, 1000 and 1500 GeV and $\tan\beta$ = 6, 12 and 25 respectively in the mh125 scenario are also provided. The combined prediction for A and H bosons with masses of 1000 and 1500 GeV is scaled by 100 in the paper figure, but not in the HepData table.
"Table 4" of "Search for heavy Higgs bosons decaying into two tau leptons with the ATLAS detector using $pp$ collisions at $\sqrt{s}=13$ TeV"
2020
Observed and predicted mTtot distribution in the b-tag category of the 2tau_h channel. Please note that the bin content is divided by the bin width in the paper figure, but not in the HepData table. The last bin includes overflows. The combined prediction for A and H bosons with masses of 400, 1000 and 1500 GeV and $\tan\beta$ = 6, 12 and 25 respectively in the mh125 scenario are also provided. The combined prediction for A and H bosons with masses of 1000 and 1500 GeV is scaled by 100 in the paper figure, but not in the HepData table.
"Table 4" of "Search for heavy Higgs bosons decaying into two tau leptons with the ATLAS detector using $pp$ collisions at $\sqrt{s}=13$ TeV"
2020
Observed and predicted mTtot distribution in the b-tag category of the 2tau_h channel. Please note that the bin content is divided by the bin width in the paper figure, but not in the HepData table. The last bin includes overflows. The combined prediction for A and H bosons with masses of 400, 1000 and 1500 GeV and $\tan\beta$ = 6, 12 and 25 respectively in the mh125 scenario are also provided. The combined prediction for A and H bosons with masses of 1000 and 1500 GeV is scaled by 100 in the paper figure, but not in the HepData table.
"Table 4" of "Search for heavy Higgs bosons decaying into two tau leptons with the ATLAS detector using $pp$ collisions at $\sqrt{s}=13$ TeV"
2020
Observed and predicted mTtot distribution in the b-tag category of the 2tau_h channel. Please note that the bin content is divided by the bin width in the paper figure, but not in the HepData table. The last bin includes overflows. The combined prediction for A and H bosons with masses of 400, 1000 and 1500 GeV and $\tan\beta$ = 6, 12 and 25 respectively in the mh125 scenario are also provided. The combined prediction for A and H bosons with masses of 1000 and 1500 GeV is scaled by 100 in the paper figure, but not in the HepData table.
"Table 2" of "Search for heavy Higgs bosons decaying into two tau leptons with the ATLAS detector using $pp$ collisions at $\sqrt{s}=13$ TeV"
2020
Observed and predicted mTtot distribution in the b-tag category of the 1l1tau_h channel. Please note that the bin content is divided by the bin width in the paper figure, but not in the HepData table. The last bin includes overflows. The combined prediction for A and H bosons with masses of 400, 1000 and 1500 GeV and $\tan\beta$ = 6, 12 and 25 respectively in the mh125 scenario are also provided. The combined prediction for A and H bosons with masses of 1000 and 1500 GeV is scaled by 100 in the paper figure, but not in the HepData table.
"Table 3" of "Search for heavy Higgs bosons decaying into two tau leptons with the ATLAS detector using $pp$ collisions at $\sqrt{s}=13$ TeV"
2020
Observed and predicted mTtot distribution in the b-veto category of the 2tau_h channel. Please note that the bin content is divided by the bin width in the paper figure, but not in the HepData table. The last bin includes overflows. The combined prediction for A and H bosons with masses of 400, 1000 and 1500 GeV and $\tan\beta$ = 6, 12 and 25 respectively in the mh125 scenario are also provided. The combined prediction for A and H bosons with masses of 1000 and 1500 GeV is scaled by 100 in the paper figure, but not in the HepData table.