Search results for " TL"

Distinct single-component adjuvants steer human DC-mediated T-cell polarization via Toll-like receptor signaling toward a potent antiviral immune res…

2021

Significance Vaccines profit from the addition of adjuvants to better and more specifically initiate, amplify, and shape immune responses. Although the number of adjuvant candidates has steadily increased, peaking in the current SARS-CoV-2 pandemic, little is known about their inherent mode of action. Using human blood immune cells, we established a multilayer method to systematically assess the adjuvants’ effects on innate and adaptive immune cells. By employing a multiplex analysis with cells from 30 different donors, we determined important patterns of adjuvant function. Moreover, we demonstrate correlates of an antiviral immune response using a Toll-like receptor 7/8 ligand adjuvant and…

Budesonide increases TLR4 and TLR2 expression in Treg lymphocytes of allergic asthmatics

2015

Abstract Background Reduced innate immunity responses as well as reduced T regulatory activities characterise bronchial asthma. Objectives In this study the effect of budesonide on the expression of TLR4 and TLR2 in T regulatory lymphocyte sub-population was assessed. Methods TLR4 and TLR2 expression in total peripheral blood mononuclear cells (PBMC), in CD4+/CD25+ and in CD4+/CD25− was evaluated, by flow cytometric analysis, in mild intermittent asthmatics (n = 14) and in controls (n = 11). The in vitro effects of budesonide in modulating: TLR4 and TLR2 expression in controls and in asthmatics; IL-10 expression and cytokine release (IL-6 and TNF-α selected by a multiplex assay) in asthmati…

Evidences of +896 A/G TLR4 Polymorphism as an Indicative of Prevalence of Complications in T2DM Patients

2014

T2DM is today considered as world-wide health problem, with complications responsible of an enhanced mortality and morbidity. Thus, new strategies for its prevention and therapy are necessary. For this reason, the research interest has focused its attention on TLR4 and its polymorphisms, particularly the rs4986790. However, no conclusive findings have been reported until now about the role of this polymorphism in development of T2DM and its complications, even if a recent meta-analysis showed its T2DM association in Caucasians. In this study, we sought to evaluate the weight of rs4986790 polymorphism in the risk of the major T2DM complications, including 367 T2DM patients complicated for th…

Forme del testo digitale

2017

L'articolo costituisce una riflessione sulla modellizzazione dei testi appartenenti alla nostra tradizione culturale in questa fase aurorale della Filologia Digitale e parte dalla domanda: che "forma" stiamo dando ai nostri testi? Vengono asplorati tre aspetti per cui i nostri modelli testuali riflettono i nostri presupposti culturali e tecnologici: in primo luogo, il modello gerarchico OHCO che sta alla base di TEI XML; in secondo luogo, il modello sequenziale alfabetico basato sulla stampa delle lingue occidentali, che sta alla base di Unicode. Un terzo aspetto, poi, è il meno esplorato nella ricerca: protocolli per la citazione testuale come CITE/CTS sono basati su corpora specifici. Per…

Speed Control of a two-Degrees of Freedom Induction Motor with Rotor Helical Motion for Industrial Applications

2014

This paper describes the realization of a two-degrees of freedom induction motor prototype with rotor helical motion, suitable for several industrial applications as grinders, augers, drilling and milling spindles, robotic arms and drives for medical tools and prostheses. This prototype was realized by combining a three-phase tubular linear induction motor (TLIM) with the stator of a three-phase rotary induction motor, resulting in a THMIM (Tubular Helical Motion Induction Motor). Moreover, a possible simple electrical drive, capable to control the helical motion, is proposed, simulated and analyzed. In particular, the mathematical model of the THMIM has been initially developed and, then, …

Fricke gel, electron spin resonance and thermoluminescence for integration and intercomparison of measurements in NCT dosimetry

2014

Aging Successfully: The Role of Genetics and Environment in the Era of the Aging-Boom. Potential Therapeutic Implications

2019

Aging is one of the main health-related challenges in the world. The average life expectancy of the global population at birth is increasing up to 72 years, in 2016 and it increases about two years every decade. The healthcare costs in many countries are very high because of the increased number of unhealthy populations, and the consequent increase of severe age-related disabilities [1]. Therefore, the goal of the future should be the achievement of the so-called “health-span” (healthy-life-span), more than the treatment of age-related disease to prevent the collapse of the health system. In order to achieve this objective, it is necessary to identify new targets and biomarkers and to addre…

TLR4 expression in ex-Lichenoid lesions—oral squamous cell carcinomas and its surrounding epithelium: the role of tumor inflammatory microenvironment

2022

Toll-like receptors (TLRs) regulate innate and adaptive immune responses. Moreover, TLRs can induce a pro-survival and pro-proliferation response in tumor cells. This study aims to investigate the expression of TLR4 in the epithelium surrounding oral squamous cell carcinomas (OSCC) in relation to its inflammatory microenvironment. This study included 150 human samples: 30 normal oral control (NOC), 38 non-lichenoid epithelium surrounding OSCC (NLE-OSCC), 28 lichenoid epithelium surrounding OSCC (LE-OSCC), 30 OSCC ex-non oral lichenoid lesion (OSCC Ex-NOLL), and 24 OSCC ex-oral lichenoid lesion (OSCC Ex-OLL). TLR4 expression was investigated by immunohistochemistry and the percentage of posi…

Chronic kidney disease and inflammation: Role of +896A/G pro-inflammatory polymorphism of TLR4 gene and Δ32 deletion of CCR5 gene

2009

bstract Chronic inflammation seems implicated in the pathophysiology of chronic kidney diseases (CKD) and the development of its complications, such as cardiovascular diseases (CVD). Genes encoding inflammatory molecules are, hence, good candidates for CVD risk in haemodialysis patients (HD). We therefore evaluated whether +896A/G TLR4 polymorphism and CCR5A32 deletion are risk factors for CKD and CVD. We examined the two gene variants in 72 HD patients and in 125 controls from Sicily. No significant differences in the genotype distribution and allele frequencies of the two gene variants were observed between patients and controls. The same results were obtained by analysing the combined ef…

Le trésor de Charles Nodier – Esquisse d’une lexicoscopie romantique

2012

Article tiré d'une communication pour la journée d'étude "Nodier et la langue - la langue de Nodier" du 01/06/2012, co-organisée par Virginie Tellier, Sébastien Vacelet et Georges Zaragoza à l'Université de Bourgogne (Dijon). Voir URL ci-jointe :; International audience