Search results for " TRANSIENT"
showing 10 items of 191 documents
Swings between rotation and accretion power in a binary millisecond pulsar
2013
It is thought that neutron stars in low-mass binary systems can accrete matter and angular momentum from the companion star and be spun-up to millisecond rotational periods1, 2, 3. During the accretion stage, the system is called a low-mass X-ray binary, and bright X-ray emission is observed. When the rate of mass transfer decreases in the later evolutionary stages, these binaries host a radio millisecond pulsar4, 5 whose emission is powered by the neutron star’s rotating magnetic field6. This evolutionary model is supported by the detection of millisecond X-ray pulsations from several accreting neutron stars7, 8 and also by the evidence for a past accretion disc in a rotation-powered milli…
Redox signaling in acute pancreatitis
2015
Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may lead to a severe systemic inflammatory response. A key event in pancreatic damage is the intracellular activation of NF-κB and zymogens, involving also calcium, cathepsins, pH disorders, autophagy, and cell death, particularly necrosis. This review focuses on the new role of redox signaling in acute pancreatitis. Oxidative stress and redox status are involved in the onset of acute pancreatitis and also in the development of the systemic inflammatory response, being glutathione depletion, xanthine oxidase activation, and thiol oxidation in proteins critical features of the disease in the pancreas. On th…
Model predictions of the ionic mechanisms underlying the beating and bursting pacemaker characteristics of molluscan neurons
1976
The general properties of the excitable membrane on molluscan pacemaker neurons can be described on the basis of a fair amount of experimental evidence available in the literature. The neuronal membrane exhibits under voltage clamp an initial inward current carried by both Na+ and Ca2+ ions, the time- and voltage-dependent characteristics of which are similar to that of other excitable structures. The conductance mechanism for the two ion species and the transport kinetics appear to be closely similar. The time course and amplitude of the delayed outward current carried by K+ ions shows a marked dependence on the membrane potential. Characteristic for the molluscan neurons is the existence …
Numerical analysis of dynamical systems : unstable periodic orbits, hidden transient chaotic sets, hidden attractors, and finite-time Lyapunov dimens…
2019
In this article, on the example of the known low-order dynamical models, namely Lorenz, Rössler and Vallis systems, the difficulties of reliable numerical analysis of chaotic dynamical systems are discussed. For the Lorenz system, the problems of existence of hidden chaotic attractors and hidden transient chaotic sets and their numerical investigation are considered. The problems of the numerical characterization of a chaotic attractor by calculating finite-time time Lyapunov exponents and finite-time Lyapunov dimension along one trajectory are demonstrated using the example of computing unstable periodic orbits in the Rössler system. Using the example of the Vallis system describing the El…
The ANTARES telescope neutrino alert system
2012
The ANTARES telescope has the capability to detect neutrinos produced in astrophysical transient sources. Potential sources include gamma-ray bursts, core collapse supernovae, and flaring active galactic nuclei. To enhance the sensitivity of ANTARES to such sources, a new detection method based on coincident observations of neutrinos and optical signals has been developed. A fast online muon track reconstruction is used to trigger a network of small automatic optical telescopes. Such alerts are generated for special events, such as two or more neutrinos, coincident in time and direction, or single neutrinos of very high energy.
Bounds on transient phase plastic deformations in optimal design of steel frames subjected to cyclic loads
2009
A minimum volume multicriterion design of elastic perfectly plastic steel frames subjected to a combination of quasi-static fixed and cyclic loads, bounding the transient phase plastic deformations, is proposed. The problem is formulated according to a plastic shakedown criterion, so that incremental and instantaneous collapse are certainly prevented when the frame is subjected to very strongly amplified cyclic loads. The further condition that the structure must also behave elastically in serviceability conditions is imposed. Since the steady-state loading history is known it is possible to directly bound the steady-state plastic deformations. By applying a suitable own bounding theorem, i…
Smoothed Particle ElectroMagnetics: A mesh-free solver for transients
2006
AbstractIn this paper an advanced mesh-free particle method for electromagnetic transient analysis, is presented. The aim is to obtain efficient simulations by avoiding the use of a mesh such as in the most popular grid-based numerical methods. The basic idea is to obtain numerical solutions for partial differential equations describing the electromagnetic problem by using a set of particles arbitrarily placed in the problem domain. The mesh-free smoothed particle hydrodynamics method has been adopted to obtain numerical solution of time domain Maxwell's curl equations. An explicit finite difference scheme has been employed for time integration. Details about the numerical treatment of elec…
Epidemiology of stroke and transient ischemic attacks: Current knowledge and perspectives
2015
International audience; Because of the growing size and aging of the world's population, the global burden of stroke is increasing dramatically. Current epidemiological data indicate that 16.9 million people suffer a stroke each year, which represents a global incidence of 258/100,000 year, with marked differences between high- and low-income countries, and an age-adjusted incidence 1.5 times higher in men than in women. Although primary prevention has contributed to a decrease in stroke incidence in high-income countries, the so-called 'epidemiological transition' has led to an increase in incidence in middle-to-low-income countries as well. In addition, the incidence of ischemic stroke in…
Action of tertiary phenylalkylamines on cardiac transient outward current from outside the cell membrane.
1996
The effects of the phenylalkylamines verapamil (V), gallopamil (G), and devapamil (D) and their corresponding quaternary derivatives on the transient outward current (Ito) were examined in rat ventricular cardiomyocytes using the whole-cell patch-clamp technique. The question was addressed, whether phenylalkylamines act on Ito from the inside or the outside or from both sides of the cell membrane. To this end, the myocytes were either superfused extracellularly or perfused intracellularly with drug-containing solutions. In addition, the effects of verapamil were investigated at different pH-values. V, G, and D (30 microM each), applied extracellularly, reduced the steady state current of It…
Effects of Quinine and Quinidine on the Transient Outward and on the L-Type Ca<sup>2+</sup> Current in Rat Ventricular Cardiomyocytes
2002
The effects of the enantiomers quinine and quinidine on the transient outward current (I<sub>to</sub>) and on the L-type Ca<sup>2+</sup> current (I<sub>Ca</sub>) were investigated in rat ventricular cardiomyocytes using the patch-clamp technique. At a stimulation frequency of 2 Hz, both quinine and quinidine depressed the magnitude of I<sub>to</sub> and I<sub>Ca</sub>; the half-maximal effects on I<sub>to</sub> were achieved at 11 and 15 µmol/l, respectively, and those on I<sub>Ca</sub> at 14 and 10 µmol/l, respectively. At 0.2 Hz, both drugs depressed the magnitude of I<sub>to</sub>, but not tha…