Search results for " TREATMENT"
showing 10 items of 3424 documents
Clinical Potential of Circulating Cell-Free DNA (cfDNA) for Longitudinally Monitoring Clinical Outcomes in the First-Line Setting of Non-Small-Cell L…
2022
Background: Despite the increasing implementation of targeted and immunotherapy-based treatments, the prognosis of patients with advanced NSCLC remains dismal. We prospectively evaluated longitudinal plasma cfDNA kinetics as an early marker of therapeutic efficacy in patients with advanced NSCLC undergoing standard first-line treatments. Methods: From February 2020 to May 2022, treatment-naïve patients with advanced NSCLC were consecutively enrolled at the Medical Oncology Unit of the Paolo Giaccone University Hospital, Palermo (Italy). We quantified cfDNA in terms of ng/μL using a QubitTM dsDNA HS Assay Kit. The agreement between the cfDNA and radiologic response was evaluated from…
Effect of RNS60 in amyotrophic lateral sclerosis: a phase II multicentre, randomized, double-blind, placebo-controlled trial
2022
Background and purpose: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal models of ALS and other neurodegenerative diseases. Its administration has been safe and well tolerated in ALS subjects in previous early phase trials. Methods: This was a phase II, multicentre, randomized, double-blind, placebo-controlled, parallel-group trial. Participants diagnosed with definite, probable or probable laboratory-supported ALS were assigned to receive RNS60 or placebo administered for 24 weeks intravenously (375 ml) once a week and via nebul…
Types, triggers and treatment strategies of psoriasis
2013
Psoriasis is a common chronic, immune mediated, inflammatory disease,characterized by periods of exacerbation and remission. Patients with psoriasis have asignificantly impaired quality of life; the disease is associated with substantial burden interms of disability or psychosocial stigmatization. Moreover, in a percentage of patientsthat varies between 5% and 42%, depending on the population studied, psoriatic arthritismay occur.Psoriasis is found worldwide but the prevalence varies among different ethnicgroups. It has a strong genetic component but environmental factors such as ß-haemolyticstreptococcal infection, HIV, stress, and drugs, including ß blockers, antimalarials andlithium can …
Real-world experience with obeticholic acid in patients with primary biliary cholangitis
2021
Background & aims Obeticholic acid (OCA) is the second-line treatment approved for patients with primary biliary cholangitis (PBC) and an inadequate response or intolerance to ursodeoxycholic acid. We aimed to evaluate the effectiveness and safety of OCA under real-world conditions. Methods Patients were recruited into the Italian PBC Registry, a multicentre, observational cohort study that monitors patients with PBC at national level. The primary endpoint was the biochemical response according to Poise criteria; the secondary endpoint was the biochemical response according to normal range criteria, defined as normal levels of bilirubin, alkaline phosphatase (ALP), and alanine aminotransfer…
Noninvasive neurostimulation methods for migraine therapy: The available evidence.
2016
Background Migraine is one of the most disabling neurological disorders. The current pharmacological armamentarium is not satisfying for a large proportion of patients because the responder rate does not exceed 50% on average and the most effective drugs often induce intolerable side effects. During recent years, noninvasive central and peripheral neuromodulation methods have been explored for migraine treatment. Overview A review of the available evidence suggests that noninvasive neuromodulation techniques could be beneficial for migraine patients. The transcranial stimulation methods allow modulating selectively cortical activity and can thus be curtailed to the patient’s pathophysiologi…
Impact assessment of a solar powered water treatment project
2015
Water treatment technologies are seen as the best alternative to be considered for adoption in developing countries where access to portable water supply that is free of pathogens is yet a challenge. This study intended to assess impact brought forth by a project, which employed a water treatment technology in rural settings of Morogoro Region in Tanzania. The project used solar photovoltaic panels to trap solar energy, converted to mechanical power to treat water with the help of sterilization ultraviolet membrane. A comparative analysis was used as an assessment framework to study impacts of the project with respect to the quality of approach used during the project life cycle. Determinan…
Vascularized lymph node transfer for treatment of extremity lymphedema: An overview of current controversies regarding donor sites, recipient sites a…
2018
As lymphatic microsurgery has become more common, vascularized lymph node transfer ascended to the forefront in many centers for the surgical management of advanced stages of lymphedema showing substantial clinical improvement. However, no consensus has been reached among experts regarding many details of the procedures, including patient selection criteria, type of treatment, donor, and recipient sites and postoperative evaluation of the outcome. Here, we will review these issues and provide the current results of this procedure.
Environmental remediation using nanomaterial as adsorbents for emerging micropollutants
2023
Water shortage and scarcity are issues of global concern. Water pollution caused by organic micropollutants further aggravates the problem, by rendering an already scarce resource unfit for human consumption. The existing conventional wastewater treatment methods and infrastructure were not designed to eliminate micropollutants. Therefore, their inefficiencies call for modern methods for removing emerging micropollutant residues such as Active Pharmaceutical Ingredients (APIs), Endocrine Disrupting Compounds (EDCs), personal care products and pesticides. The use of nanomaterials, for the abatement of micropollutants in water is gaining traction in recent years, due to the abundance of susta…
Platelet cut-off for anticoagulant therapy in thrombocytopenic patients with blood cancer and venous thromboembolism: an expert consensus
2019
Background. Management of venous thromboembolism (VTE) in patients with haematologic malignancies and thrombocytopenia is clinically challenging due to the related risks. No prospective studies or clinical trials have been carried out and, therefore, no solid evidence on this compelling issue is available. Methods. Given this, an expert panel endorsed by the Gruppo Italiano Malattie Ematologiche dell'Adulto Working Party on Thrombosis and Haemostasis was set up to produce a formal consensus, according to the RAND method, in order to issue clinical recommendations about the platelet (PLT) cut-off for safe administration of low molecular weight heparin (LMWH) in thrombocytopenic (PLT <100×…