Search results for " TYR"
showing 10 items of 362 documents
Two new apricot varieties
2010
Nella and Dora are apricot seedlings recently selected by R. Chiappetta in Sicily. Their vegetative, floreal, agronomic and fruit-quality characteristics were checked for three years (2003 - 2005) in Partinico (Palermo coast area), under mild winter and spring temperatures, in comparison with Tyrinthos variety. Nella and Dora have an upright tree habit and are self-compatible. Blooming started a week earlier in Nella and Tyrinthos (end of February) and concluded in the second part of March in all varieties. Fruit set was satisfactory in all cultivars. Crop was harvested from May 25th to 30th in Dora, May 24th to 30th in Nella and May 24th to 28th in Tyrinthos. Fruit weight, as a three years…
Serve ancora ucidere i tiranni? A proposito di Ps. Quint. decl. min. 253
2018
The paper deals with Ps. Quint. decl. min. 253; in the text, concerning one of the best-known themes of the declamatory literature, a tyrannicide, after killing a tyrant, asks the community for approval of a rogatio in order to be sent to the tyrant of the nearby city. The declamation focuses on a hero willing to put the salvation of the community before his own, a theme certainly usual in Latin thought, but which traces new interpretative ways in the declamatory culture.
Entrectinib: a potent new TRK, ROS1, and ALK inhibitor
2015
Abstract: Introduction: Receptor tyrosine kinases (RTKs) and their signaling pathways, control normal cellular processes; however, their deregulation play important roles in malignant transformation. In advanced non-small cell lung cancer (NSCLC), the recognition of oncogenic activation of specific RTKs, has led to the development of molecularly targeted agents that only benefit roughly 20% of patients. Entrectinib is a pan-TRK, ROS1 and ALK inhibitor that has shown potent anti-neoplastic activity and tolerability in various neoplastic conditions, particularly NSCLC. Areas covered: This review outlines the pharmacokinetics, pharmacodynamics, mechanism of action, safety, tolerability, pre-cl…
Antagonistic feedback loops involving Rau and Sprouty in the Drosophila eye control neuronal and glial differentiation.
2013
During development, differentiation is often initiated by the activation of different receptor tyrosine kinases (RTKs), which results in the tightly regulated activation of cytoplasmic signaling cascades. In the differentiation of neurons and glia in the developing Drosophila eye, we found that the proper intensity of RTK signaling downstream of fibroblast growth factor receptor (FGFR) or epidermal growth factor receptor required two mutually antagonistic feedback loops. We identified a positive feedback loop mediated by the Ras association (RA) domain-containing protein Rau that sustained Ras activity and counteracted the negative feedback loop mediated by Sprouty. Rau has two RA domains t…
Toward more realistic viscosity measurements of tyre rubber–bitumen blends
2014
AbstractThe measurement of rheological properties of the tyre rubber bitumen blends is often challenging due to presence of suspended tyre rubber’s crumbs. Furthermore, the phase separation during the course of measurements makes the viscosity of these non-homogeneous blends difficult to ascertain. In this study, a new dual helical impeller was designed and manufactured to be used with a rotational viscometer in order to have a real-time control of the viscosity while performing a laboratory mixing of the blends. Layer based manufacturing techniques showed to be a convenient method to produce complex shaped impeller prototypes before manufacturing the more expensive stainless steel assembly…
Optimisation of liquid rubber modified bitumen for road pavements and roofing applications
2020
Abstract Polymer Modified Bitumens (PMBs) are largely used for pavement and roofing membranes applications with Styrene-Butadiene-Styrene Block copolymer (SBS) playing a major role in both markets despite its constantly increasing price due to the rising demand for quality bitumen modifiers. On the other hand, there is an increasing trend of recycling end of life tyres generating Recycled Tyre Rubber (RTR) at affordable price. This investigation aims at engineering a modified bitumen with a combination of Liquid Rubber (LR), a homogeneous blend of 50–70% RTR pre-processed in combination with heavy oils, and a wax denominated Ethylene Bis Stearamide (EBS). In the first phase, the effect of L…
A case of renal carcinoma metastasis simulating a thyroid goiter
2011
Background: Although the thyroid is a highly vascularized gland, it is not a common target of metastasis from extrathyroidal cancer. Clear-cell renal carcinoma (cRCC) frequently metastasizes to the thyroid, representing 2-3% of all adult tumors, and more than 40% of patients present with metastases at diagnosis. The presence of cRCC thyroidal metastases makes the differential diagnosis from thyroid clearcell carcinoma extremely difficult. Patients and Methods: A 70-year-old woman presented with a mild compressive symptomatology due to a recent multinodular thyroid goiter with a ‘simple’ multinodular ultrasound pattern, in the absence of signs of malignancy and with normal findings for hormo…
Tectono-stratigraphic modelling of the North Sicily continental margin (southern Tyrrhenian Sea).
2004
A two-dimensional numerical modelling that simulate the kinematic and thermal response of the lithosphere to thinning was used for the quantitative reconstruction of the late Neogene to Recent times tectonic and stratigraphic evolution of the North Sicily continental margin (southern Tyrrhenian Sea). The numerical study of the evolution of the North Sicily margin builds on the crustal image and kinematic interpretation of the margin obtained by Pepe et al. [Tectonics 19 (2000) 241] on the basis of seismic data and gravity modelling. Tectonic modeling indicate that different segments of the margin were undergoing different vertical movements, which are mainly expression of the rifting and th…
Role of PTPRJ genotype in papillary thyroid carcinoma risk
2010
The strong genetic predisposition to papillary thyroid carcinoma (PTC) might be due to a combination of low-penetrance susceptibility variants. Thus, the research into gene variants involved in the increase of susceptibility to PTC is a relevant field of investigation. The gene coding for the receptor-type tyrosine phosphatase PTPRJ has been proposed as a cancer susceptibility gene, and its role as a tumor suppressor gene is well established in thyroid carcinogenesis. In this study, we want to ascertain the role of PTPRJ genotype in the risk for PTC. We performed a case–control study in which we determined the PTPRJ genotype for the non-synonymous Gln276Pro and Asp872Glu polymorphisms by PC…
The nucleotide and partial amino acid sequences of rat fetuin. Identity with the natural tyrosine kinase inhibitor of the rat insulin receptor.
1992
Fetuins are among the major plasma proteins, yet their biological role has remained elusive. Here we report the molecular cloning of rat fetuin and the sequence analysis of a full-length clone, RF619 of 1456 bp with an open reading frame of 1056 bp encoding 352 amino acid residues. The coding part of RF619 was identical with the cDNA sequence of the natural inhibitor of the insulin receptor tyrosine kinase from rat (pp63) except for four substitutions and a single base insertion causing divergence of the predicted protein sequences. Partial amino acid sequences of rat plasma fetuin were in agreement with the predictions based on the RF619 cDNA. Purified rat fetuin inhibited the insulin rece…