Search results for " TYR"
showing 10 items of 362 documents
Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor.
2004
The Trk family of receptor tyrosine kinases and the p75 receptor (p75NTR) mediate the effects of neurotrophins on neuronal survival, differentiation and synaptic plasticity. The neurotrophin BDNF and its cognate receptor tyrosine kinase, TrkB.FL, are highly expressed in neurons of the central nervous system. At later stages in postnatal development the truncated TrkB splice variants (TrkB.T1, TrkB.T2) become abundant. However, the signalling and function of these truncated receptors remained largely elusive.We show that overexpression of TrkB.T1 in hippocampal neurons induces the formation of dendritic filopodia, which are known precursors of synaptic spines. The induction of filopodia by T…
TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling
2007
The epithelial-to-mesenchymal transition (EMT) is a crucial process, occurring both during development and tumor progression, by which an epithelial cell undergoes a conversion to a mesenchymal phenotype, dissociates from initial contacts and migrates to secondary sites. We recently reported that in hepatocytes the multifunctional cytokine TGFβ induces a full EMT characterized by (i) Snail induction, (ii) E-cadherin delocalization and down-regulation, (iii) down-regulation of the hepatocyte transcriptional factor HNF4α and (iv) up-regulation of mesenchymal and invasiveness markers. In particular, we showed that Snail directly causes the transcriptional down-regulation of E-cadherin and HN…
Interactions between cholinergic and fibroblast growth factor receptors in brain trophism and plasticity
2014
Acetylcholine, acting on both nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs), plays a role in the regulation of synaptic plasticity, being involved in the regulation of cellular processes and cognitive functions, such as learning, memory and attention. Recently, G protein coupled receptors (GPCRs), including mAChRs, have been reported to transactivate tyrosine-kinase receptors (RTK), such as epidermal growth factor receptor (EGFR), and initiate their intracellular signaling. In this minireview we have first analysed the RTK transactivation mechanisms, involving cholinergic receptors, and thereafter the interplay between AChR and neurotrophic factor systems built up by FGF2 a…
EVOLUTION OF THE INNATE AND ADAPTIVE IMMUNE SYSTEMS
1999
Porifera (sponge) form the lowest metazoan phylum and share a common ancestor with other metazoan phyla. In the present study, it is reported that sponges possess molecules that are similar in structure to those molecules involved in the immune system in mammals. Experiments with the marine sponges Geodia cydonium and Suberites domuncula have been performed on tissue (auto- and allografting) as well as on a cellular level. The studies revealed that sponges are provided with elements of the mammalian innate immune system, such as molecules containing scavenger receptor cysteine-rich domains. Furthermore, macrophage-derived cytokine-like molecules have been identified that are up-regulated du…
Abstract 4372: Chronic myeloid leukemia (CML) exosomes promote angiogenesis in a Src-dependent fashion in vitro and in vivo
2012
Abstract CML is an uncontrolled proliferation of bone marrow myeloid cells driven by the constitutively active fusion product tyrosine kinase BCR/ABL. Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is newly recognized as a factor in CML progression. Exosomes, released by a broad spectrum of cells, are microvesicles that play an important role in cell-to-cell communication both in physiological and pathological conditions. The role of exosomes released by CML cells in angiogenesis is emerging; however, little is known about the mechanisms involved in this process. We first isolated and characterized exosomes released by K562 CML cells and we demonstrated thei…
Induction of rapid and reversible cytokeratin filament network remodeling by inhibition of tyrosine phosphatases
2002
The cytokeratin filament network is intrinsically dynamic, continuously exchanging subunits over its entire surface, while conferring structural stability on epithelial cells. However, it is not known how cytokeratin filaments are remodeled in situations where the network is temporarily and spatially restricted. Using the tyrosine phosphatase inhibitor orthovanadate we observed rapid and reversible restructuring in living cells, which may provide the basis for such dynamics. By examining cells stably expressing fluorescent cytokeratin chimeras, we found that cytokeratin filaments were broken down and then formed into granular aggregates within a few minutes of orthovanadate addition. After …
Sea-level changes during the last 41,000 years in the outer shelf of the southern Tyrrhenian Sea: Evidence from benthic foraminifera and seismostrati…
2011
Abstract An integrated high resolution study based both on a seismostratigraphic approach and on a sedimentary core (VIB 10), collected in the outer shelf (127 m depth) from the southern Tyrrhenian Sea (Gulf of Termini, Sicily), provides new data about climatic, eustatic and paleoenvironmental changes during the last ∼41,000 years. The results based on the interpretation of a seismic profile, on benthic foraminifera assemblages and on δ18O records, allowed recognition of two drastic sea-level falls during the Last Glacial Maximum (LGM) and the Younger Dryas (YD). The short deglacial event, between LGM and YD, known as Bolling/Allerod, played an important role in the sea-level rise that prod…
First considerations on post processing kinematic GNSS data during a geophysical oceanographic cruise
2021
<p class="Abstract">Differential GNSS positioning on vessels is of considerable interest in various fields of application as navigation aids, precision positioning for geophysical surveys or sampling purposes especially when high resolution bathymetric surveys are conducted. However ship positioning must be considered a kinematic survey with all the associated problems. The possibility of using high-precision differential GNSS receivers in navigation is of increasing interest, also due to the very recent availability of low-cost differential receivers that may soon replace classic navigation ones based on the less accurate point positioning technique. The availability of greater plano…
Growth and geomorphic evolution of the Ustica volcanic complex at the Africa-Europe plate margin (Tyrrhenian Sea)
2021
18 pages, 13 figures, 1 table
Magmatism Along Lateral Slab Edges: Insights From the Diamante-Enotrio-Ovidio Volcanic-Intrusive Complex (Southern Tyrrhenian Sea)
2019
Volcanic‐intrusive complexes often formed along lateral slab edges as a consequence of subduction‐induced mantle flow. We investigate this process in the southern Tyrrhenian Sea by integrating multibeam bathymetry, seismic‐reflection data, regional magnetic anomalies data, and seismological data. The interpretation of the data highlights the presence of magmatic intrusions that locally reach the seafloor forming volcanic edifices. Chimneys, lava flows, and laccoliths are observed beneath and surrounding the volcanoes. The emplacement and cooling of the magma occurred during the Brunhes Chron. The volcanoes are not active even if the hydrothermal activity occurs. The volcanic‐intrusive compl…