Search results for " TYR"

The southern Tyrrhenian Sea margin an example of lithospheric scale strike-slip duplex

2010

The southern Tyrrhenian Sea margin is dominated by deformations whose kinematics are relatively poorly constrained, and different models have been proposed to account for its recent evolution. Analysis of new structural and space geodesy data, combined with available geophysical information, reveal a deformation field characterised by subhorizontal NW-SE directed shortening and SW-NE directed extension. The main recognised regional-scale structure comprises E-W trending fault zones, namely the Ustica-Eolie Line and the Mt. Kumeta-Alcantara Line, connected by the NW-SE trending Marettimo, Trapani, San Vito, Palermo, Gratteri-Mt. Mufara and Eolie faults. This fault network displays a remarkab…

Encuentros y desencuentros de la Antigüedad tardía con la Edad Media en el "Libro de Apolonio"

2018

El Libro de Apolonio es un poema compuesto seguramente hacia 1240, conservado en una única copia de la segunda mitad del siglo XIV, y basado en un texto latino, la Historia Apollonii regis Tyri, quizá procedente de otro griego, que se origina en los primeros siglos de nuestra era, adquiere cierta forma en los siglos V o VI, y se sigue transmitiendo y modificando a lo largo de la Edad Media. El artí-culo estudia algunos encuentros y desencuentros de la Antigüedad tardía con la Edad Media que revelan las distintas capas textuales presentes en el Libro de Apolonio, fundamentalmente en lo que se refiere a su encaje literario, especialmente genérico, y al modo de presentar la «cortesía» como mat…

Oxidative stress, a new hallmark in the pathophysiology of Lafora progressive myoclonus epilepsy

2015

12 páginas, 4 figuras, 1 tabla

Ubiquitin conjugating enzyme E2-N and sequestosome-1 (p62) are components of the ubiquitination process mediated by the malin-laforin E3-ubiquitin li…

2015

11 páginas, 9 figuras.

Light-induced resistance of the keratin network to the filament-disrupting tyrosine phosphatase inhibitor orthovanadate.

2003

Epidermal keratinocytes respond to low-dose light irradiation by inducing signaling cascades that lead to long-term effects on gene transcription thereby protecting cells against damage. In contrast, little is known about immediate light-induced alterations of structural proteins. We have made the intriguing observation that light produces fundamental changes in the properties of the keratin filament system of cultured epidermoid A-431 cells. A short light exposure (1–10 min) causes the keratin cytoskeleton to become immediately resistant to the tyrosine phosphatase inhibitor orthovanadate, which otherwise disrupts the keratin filament network completely in just a few minutes. This protecti…

A GEOSITE TO BE SAVED: THE TYRRHENIAN FOSSIL DEPOSIT ON THE ISLAND OF USTICA

2014

During the 1960s, fossil beds characterized by a tropical-sea malacofauna were discovered by G. Ruggieri and G. Buccheri in the Island of Ustica, on the southern slope of Falconiera hill, 32 m asl. Thanks to the presence of Strombus bubonius and other Senegalese guests, the authors estimated that the molluscan fauna had lived around 125,000 years ago, during the Tyrrhenian stage. Recently on the initiative of the “Centro Studi e Documentazione Isola di Ustica”, a research has been initiated to verify the persistence of sand-layers mixed up with Tyrrhenian fossils, even though, in the last 50 years, that area has undergone great changes, because of earthworks which have sealed the deposit. T…

Innovative Vehicle-Trailer Connection for Yaw Stability Improvement

2014

As well known, dangerous conditions may occur for the lateral stability of the road vehicles on increasing the running velocity. While it is easy to make up for this drawback in the case of a vehicle alone, by a proper weight distribution, the unstable trend may worsen unfavourably for the vehicle-trailer configuration, imposing a very hard correction task to the driver, who has to cope with the development of two types of instability, exponentially divergent or swaying with increasing amplitude. The critical velocity depends on the geometrical and inertial characteristics of the car-trailer system, on the cornering stiffness of the tires and on the weight distribution among the axles. The …

Thérapies ciblées et diabète

2017

DIEL ACTIVITY AND HOME RANGE OF THE WHITE SEABREAM DIPLODUS SARGUS SARGUS (LINNAEUS, 1758) IN THE GULF OF CASTELLAMMARE (NW SICILY)

2011

Rat tyrosine kinase inhibitor shows sequence similarity to human α2-HS glycoprotein and bovine fetuin

1991

Human alpha 2-HS glycoprotein and bovine fetuin, abundant proteins of fetal plasma, are structural members of the fetuin family within the cystatin superfamily. They are characterized by the presence of two N-terminally located cystatin-like units and a unique C-terminal sequence segment not present in the other members of the cystatin superfamily. Search for related sequences revealed that the natural inhibitor of the insulin receptor tyrosine kinase [Auberger, Falquerho, Contreres, Pages, Le Cam, Rossi & Le Cam (1989) Cell (Cambridge, Mass.) 58, 631-640] shows sequence similarity to the mammalian fetuins. The sequence identity between rat tyrosine kinase inhibitor, human alpha 2-HS gl…