Search results for " TYR"
showing 10 items of 362 documents
Disumano, troppo umano. La maschera del tiranno e l’antropologia dei filosofi (da Sofocle a Seneca)
2019
Tyranny is often regarded as "a perennial problem" (Boesche 1996) on the basis of its ubiquitous presence in literature. Even more enduring is the problem of how to define human nature, its place in the environment, and its relationship to the divine – a core issue of philosophical anthropology (Pansera 2001, Honenberger 2015). In the present paper, I shall approach the literary construction of the tyrant figure in Greek and Roman tragedy from the holistic perspective of philosophical anthropology. I will focus on three well-known dramas (Sophocles’ Oedipus the King and Antigone and Seneca’s Thyestes) which put great emphasis on the moral and cognitive status of tyrants as “exceptional” hum…
Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 ph…
2006
Aplidin® is an antitumor agent in phase II clinical trials that induces apoptosis through the sustained activation of Jun N-terminal kinase (JNK). We report that Aplidin® alters glutathione homeostasis increasing the ratio of oxidized to reduced forms (GSSG/GSH). Aplidin® generates reactive oxygen species and disrupts the mitochondrial membrane potential. Exogenous GSH inhibits these effects and also JNK activation and cell death. We found two mechanisms by which Aplidin® activates JNK: rapid activation of Rac1 small GTPase and downregulation of MKP-1 phosphatase. Rac1 activation was diminished by GSH and enhanced by L-buthionine (SR)-sulfoximine, which inhibits GSH synthesis. Downregulatio…
New seismological and geological-structural contributions to the support of a seismotectonic model of the hinge area between northern Sicily and sout…
2012
Submarine Slope Failures Along the Northern Sicilian Continental Margin (Southern Tyrrhenian Sea) and Possible Implications for Geo-Hazard
2013
Mass wasting and downslope movements are common processes that have contributed to shape the northern Sicilian continental margin (southern Tyrrhenian Sea) since the Late Quaternary. Nevertheless, processes controlling their evolution are still partially unknown and a variety of geologic factors can be responsible for their formation. In this work we present an overview of the main mass wasting features (submarine canyons, landslides, debris flows) observed and mapped in different sectors of the northern Sicilian margin. The margin is characterized by a narrow, steep continental shelf (1-2°) and a very irregular and steep (6-8°) upper slope. The main aims of this work are: (1) to outline th…
Submarine canyon of the north-western Sicilian offshore (Southern Tyrrhenian Sea): variability in morphologies, sedimentary processes and tectonic se…
2013
Protein tyrosine nitration and thiol oxidation by peroxynitrite-strategies to prevent these oxidative modifications.
2013
The reaction product of nitric oxide and superoxide, peroxynitrite, is a potent biological oxidant. The most important oxidative protein modifications described for peroxynitrite are cysteine-thiol oxidation and tyrosine nitration. We have previously demonstrated that intrinsic heme-thiolate (P450)-dependent enzymatic catalysis increases the nitration of tyrosine 430 in prostacyclin synthase and results in loss of activity which contributes to endothelial dysfunction. We here report the sensitive peroxynitrite-dependent nitration of an over-expressed and partially purified human prostacyclin synthase (3.3 μM) with an EC50 value of 5 μM. Microsomal thiols in these preparations effectively co…