Search results for " Themes"

European perspective on the 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroi…

2018

The American Thyroid Association (ATA) management guidelines for patients with thyroid nodules and differentiated thyroid cancer (DTC) are highly influential practice recommendations. The latest revision appeared in 2015 ("ATA 2015"). These guidelines were developed predominantly by North American experts. European experts frequently have different perspectives, given epidemiological, technological/methodological, practice organization, and medicolegal differences between the respective regions.Divergent viewpoints were the focus of an invited symposium organized by the European Association of Nuclear Medicine involving 17 European thyroidologists, four ATA Guidelines Taskforce members, and…

A novel device for intracolonoscopy cleansing of inadequately prepared colonoscopy patients: a feasibility study.

2019

Abstract Background The importance of high quality preprocedural bowel preparation is widely acknowledged, but suboptimal bowel cleansing still occurs in up to 20 % of all colonoscopy patients. The aim of this study was to evaluate the performance of a novel intraprocedural cleaning device for cleaning poorly prepared colons. Methods This multicenter feasibility study included patients aged 18 – 75 years who were referred for colonoscopy. Intraprocedural cleaning was performed in patients after a limited preprocedural bowel preparation regimen (2 days of dietary restrictions and 2 × 10 mg bisacodyl). The primary outcome was the proportion of adequately prepared patients (Boston Bowel Prepar…

Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tum…

2021

Simple Summary Variable domains of heavy chain only antibodies are small proteins that can be used for tumor imaging and therapy upon conjugation of functional groups. As frequently used random conjugation techniques can decrease binding to the target of interest, site-specific conjugation of these functional groups is preferred. Here, we optimized site-specific conjugation of both a chelator for binding of a radiometal and a photosensitizer to epidermal growth factor receptor (EGFR) binding VHH 7D12. We characterized this dual-labeled VHH for nuclear imaging and targeted photodynamic therapy of EGFR-expressing tumors. Abstract Variable domains of heavy chain only antibodies (VHHs) are valu…

Enhanced Spatial Navigation Skills in Sequence-Space Synesthetes

2018

Contains fulltext : 219554.pdf (Publisher’s version ) (Closed access) Individuals with sequence-space synesthesia (SSS) perceive sequences like months, days and numbers in certain spatial arrangements. Several cognitive benefits have been associated with SSS, such as enhanced mental rotation, more vivid visual imagery and an advantage in spatial processing. The current study aimed to further investigate these cognitive benefits, focusing on spatial navigation skills, to explore if their enhanced sensitivity to spatial relations is reflected in enhanced navigational performance. Synesthetes were distinguished from controls by means of a questionnaire, a consistency test and drawings. A virtu…

Measuring Behavior in the Home Cage: Study Design, Applications, Challenges, and Perspectives

2021

Contains fulltext : 239279.pdf (Publisher’s version ) (Open Access) The reproducibility crisis (or replication crisis) in biomedical research is a particularly existential and under-addressed issue in the field of behavioral neuroscience, where, in spite of efforts to standardize testing and assay protocols, several known and unknown sources of confounding environmental factors add to variance. Human interference is a major contributor to variability both within and across laboratories, as well as novelty-induced anxiety. Attempts to reduce human interference and to measure more "natural" behaviors in subjects has led to the development of automated home-cage monitoring systems. These syste…

Architettura in alzato. Questioni di territorio, paesaggio, ambiente

2021

Negata alla tipologia l’architettura del Sud nel saggio riconosce una specifica identità e perfetta eccezionalità nell’essenza del luogo. Se la facciata istituisce un rapporto con l’estetica del paesaggio, i temi che essa sottende definiscono altre significative relazioni. L’ordinamento logico delle membrature, la chiarezza geometrica e il rigore dei rapporti rimandano ad una architettura che si misura, ed è misura stessa, del territorio e della sua morfologia. A sua volta, lo spessore della facciata esprime la relazione con l’ambiente e interpreta in maniera poetica i condizionamenti climatici, intervenendo sul controllo della luce, sui vuoti nei paramenti murari, sulla determinazione dell…

Training for gender equity: an experience through choreographies in Early Childhood Education

2020

INTRODUCCIÓN. En Educación Infantil, el trabajo de los denominados temas transversales toma especial relevancia porque permiten reforzar las destrezas del alumnado en diferentes áreas, que contribuyen a un desarrollo adecuado durante la Educación Primaria. Los contenidos de la asignatura “Procesos musicales en Educación Infantil”, de tercer curso del Grado de Maestra de Educación Infantil, permiten el trabajo de esos temas, concretamente, las coreografías. Éstas pueden ser utilizadas como herramientas lúdicas que garantizan no sólo el trabajo de las habilidades motrices básicas, sino también la equidad, la educación cívica y moral…, por el contenido de las canciones que pueden ser utilizada…

The fantastic in The Magus by John Fowles

2000

A life put on pause: an exploration of the health-related quality of life issues relevant to adolescents and young adults with cancer

2018

Purpose: in recent years, the assessment of health-related quality of life (HRQoL) has been recognized as particularly informative to health care providers. For adolescents and young adults (AYAs), the impact of a cancer diagnosis and subsequent treatment is likely to be distinct from other age groups given the unique and complex physical and psychosocial challenges of this developmental phase. The objective of this study was to capture the HRQoL issues described by AYAs with cancer using thematic analysis.Methods: semi-structured interviews were carried out with 45 AYAs aged 14-25 years from 6 countries. Results: the most prevalent cancers presented were leukemia (n=12) and lymphoma (n=8).…

Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes

2019

Importance: Both low and high gestational weight gain have been associated with adverse maternal and infant outcomes, but optimal gestational weight gain remains uncertain and not well defined for all prepregnancy weight ranges. Objectives: To examine the association of ranges of gestational weight gain with risk of adverse maternal and infant outcomes and estimate optimal gestational weight gain ranges across prepregnancy body mass index categories. Design, setting, and participants: Individual participant-level meta-analysis using data from 196 670 participants within 25 cohort studies from Europe and North America (main study sample). Optimal gestational weight gain ranges were estimated…