Search results for " Transformation"
showing 10 items of 1043 documents
Rho GTPases: Promising Cellular Targets for Novel Anticancer Drugs
2006
Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho GTPases are localized at membranes and become activated upon stimulation of cell surface receptors. In their GTP-bound (=active) state, Rho proteins bind to effector proteins, thereby triggering specific cellular responses. Members of the Rho family of small GTPases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ECM) adhesion as well as of cell cycle progression, gene expression and apoptosis. Each of these functions is of importance for the development and progression of cancer. Fu…
Chirurgische Ausbildung im digitalen Zeitalter – Virtual Reality, Augmented Reality und Robotik im Medizinstudium
2021
The digital transformation of healthcare is changing the medical profession. Augmented/Virtual Reality (AR/VR) and robotics are being increasingly used in different clinical contexts and require supporting education and training, which must begin within the medical school. There is currently a large discrepancy between the high demand and the number of scientifically proven concepts. The aim of this thesis was the conceptual design and structured evaluation of a newly developed learning/teaching concept for the digital transformation of medicine, with a special focus on the influence of surgical teaching.Thirty-five students participated in three courses of the blended learning curriculum "…
Tulevat ilmastot ja sosiaalityön etiikka
2018
Sosiaalityössä olisi kiireesti terävöitettävä tilallisesti ja ajallisesti kaukaisia toisia koskevaa etiikka, jotta ala kykenisi nykyistä paremmin reagoimaan globaaleihin tai ajan myötä kumuloituviin uhkiin ja niiden aiheuttamaan haavoittuvuuteen. Erityisen ajankohtaiseksi asian tekee ihmisen aiheuttama ilmastonmuutos, joka lisää jo nyt (noin +1⁰ esiteollisesta ajasta) eriarvoisuutta ja haavoittuvuutta esimerkiksi konfliktien, siirtolaisuuden, ruokapulan ja sairauksien taustatekijänä. Vaikka kukaan ei ole suojassa ilmaston lämpenemisen vaikutuksilta, kaikkein suojattomimpia ovat köyhät, marginalisoidut ja muuten haavoittuvissa asemissa olevat ihmiset, joiden resurssit suojautua ja sopeutua o…
Data practices and inequality in South African early childhood development policy: Technocratic management versus social transformation
2019
Background: In 1994, the African National Congress identified early childhood development as a potential strategy to redress the inequalities of apartheid, however, two and a half decades later, poverty still persists, and South Africa is one of the most unequal countries in the world. Aim: This article explores how policy texts based on and with the use of certain data practices establish ‘truths’ about childhoods and society, construct families and communities, and determine forms of provision to address inequality. Setting: In 2015, the South African government published the National Integrated Early Childhood Policy (NIECDP) to continue to address poverty and inequality. Its implementat…
Understanding the impact of digital on performing arts: a systematic literature review proposal
2023
Digital technologies have profoundly changed the cultural and creative industries. Due to the intrinsic characteristics of the performing arts sector, this digital transition has had a later impact on it. However, it has accelerated since the Covid-19 pandemic, forcing organizations to digitally transform themselves to keep in touch with their audience(s). Now that this crisis is over, many strategic and operational questions still remain unanswered. This research proposes a systematic literature review in order to establish the state of the art of the research on digitalization of the performing arts sector and to highlight the main research avenues to be explored.
Transformation of proliferative verrucous leukoplakia to oral carcinoma: a ten years follow-up
2004
Los autores presentan un caso de leucoplasia verrugosa proliferativa (LVP) en varón de 78 años de edad. Fue inicialmente presentado como un caso de leucoplasia en lengua pero un estudio microscópico en 1991 reveló la presencia de displasia epitelial leve. Tras 5 años de seguimiento, la lesión sufrió cambios de tamaño y localización y tuvo comportamiento recidivante. En 1996, un área eritematosa granular e indurada que apareció en lengua resultó ser un carcinoma de células escamosas microinvasivo cuando se estudió microscópicamente. Tras una revisión del comportamiento clinicopatológico de esta entidad, los autores concluyeron que se trataba de una leucoplasia verrugosa proliferativa, cuyo d…
Oral pigmented lesions:a retrospective analysis from Brazil
2020
Background Pigmented lesions are uncommon in the oral mucosa, and studies investigating the incidence and types of these lesions are desired to improve the diagnostic knowledge of clinicians. The aim of this study was to analyze the distribution of oral pigmented lesions in a Brazilian population. Material and Methods A retrospective descriptive cross-sectional study was performed. Oral pigmented lesions were retrieved from the files of two oral and maxillofacial pathology services from Brazil over a 45-year period (1974-2019). The clinical data and the diagnoses of each case were retrieved and included in a Microsoft Excel® database. Results From 77.074 lesions diagnosed in this period, 76…
Behind the scenes of artificial intelligence: a study of micro-work platforms in France
2019
Este artículo es una versión resumida del informe “Le Micro-travail en France. Derrière l’automatisation de nouvelles précarités au travail?» This article is a summarized version of the report "Le Micro-travail en France. Derrière l’automatisation de nouvelles précarités au travail?" .; International audience; Micro-work internet services allocate small, standardized tasks of data generation and annotation to crowds of providers. The outputs are mainly used to produce artificial intelligence solutions. It is an exemplary instance of the “platformization” of the economy, and of the transformations of labour that digital technologies bring about. To uncover the conditions under which micro-wo…
Carleson's counterexample and a scale of Lorentz-BMO spaces on the bitorus
2005
We introduce a full scale of Lorentz-BMO spaces BMO L p,q on the bidisk, and show that these spaces do not coincide for different values ofp andq. Our main tool is a detailed analysis of Carleson's construction in [C].
Corporate business model transformation and inter-organizational cognition: the case of Nokia
2013
This article distinguishes between a firm’s corporate business model and business models of its various business units. Our aim is to provide new insights into how executives’ cognitive processes can influence corporate business model transformation decisions. We focus especially on top managers’ recognition of inter-organizational cognitions, that is, such cognitions about the firm and its businesses that are shared by the top managers and stakeholders of the firm in the industries and communities where it operates. We support our theoretical work with an historical case study of Nokia’s corporate business model transformation between 1990 and 1996, which proved highly successful. We find …