Search results for " Transformation"
showing 10 items of 1043 documents
Wip1 phosphatase: between p53 and MAPK kinases pathways.
2016
IF 5.008; International audience; Cells undergoing oncogenic transformation frequently inactivate tumor suppressor pathways that could prevent their uncontrolled growth. Among those pathways p53 and p38MAPK pathways play a critical role in regulation of cell cycle, senescence and cell death in response to activation of oncogenes, stress and DNA damage. Consequently, these two pathways are important in determining the sensitivity of tumor cells to anti-cancer treatment. Wild type p53-induced phosphatase, Wip1, is involved in governance of both pathways. Recently, strategies directed to manipulation with Wip1 activity proposed to advance current day anticancer treatment and novel chemical com…
Hybrid State Feedback Position-Force Control of Hydraulic Cylinder
2019
A hybrid position-force control is proposed using a unified state feedback controller in combination with feedforward dead-zone compensation. Dead-zone compensator was constructed as inverse of the identified static map while the state feedback gains were obtained using a numerical optimization routine. An accurate state-space model affine in states and control, derived in a previous work, was used for closed-loop simulations and control tuning. A trigger event for automatic switching between position and force control was defined and integrated into overall control architecture alongside with a feedforward low-pass filter reducing high frequency components in the control signal. Experiment…
Impact of the information provided to consumers on their willingness to pay for Champagne : comparison with hedonic scores
2002
International audience; L'étude a été effectuée afin de comparer deux mécanismes destinés à révéler les préférences des consommateurs : une enchère Vickrey qui mesure la disposition à payer, et un test hédonique classique. A travers ces deux méthodes, l'objectif était d'estimer les effets respectifs des caractéristiques sensorielles et de l'information externe sur l'évaluation de cinq champagnes brut non millésimés. Cent-ving-trois consommateurs ont été assignés au hasard aux deux groupes et ont utilisé l'une des méthodes. Quelle que soit la méthode, ils ont évalué les champagnes à l'aveugle, puis sur la base d'une présentation des bouteilles et, enfin, après l'observation de la bouteille e…
[Qualité attendue contre qualité perçue : arbitrage avec les prix]
2000
International audience; Cet article rend compte d'une étude menée afin de comparer le comportement des consommateurs qui doivent choisir des produits sous contrainte économique, selon deux conditions différentes : quand la qualité perçue est basée sur une attente générée par des images fabriquées et, à l'inverse, quand la qualité perçue est basée sur l'expérience sensorielle en présence d'images fabriquées. Les participants de l'expérience ont été choisis au hasard, dotés d'un budget réel et placés dans cinq situations différentes de prix/budget. Ils ont formulé leurs choix parmi six jus d'orange dans chaque situation prix/budget. Ce travail a été réalisé pour les deux conditions différente…
Ecovillages in Spain: Searching an emancipatory social transformation?
2018
Today the second most important country after the United States, in the number of ecovillages, and by far, the most prominent in Europe, is Spain. The question to be addressed here is whether this revival or boom of ecovillages in Spain is an incipient social transformation and cultural change, following Erik Olin Wright theory of emancipatory social transformation. This work is divided into five main sections. The first one introduces three different approaches that remark the importance of ecovillages for radical cultural and social studies. The second part explains the methodology performed for the study of 29 ecovillages in Spain, using six critical variables on material interests and i…
An Easy Game? Experiences of ‘Homecoming’ in the Post-Socialist Context of Croatia and the Czech Republic
2016
The obstacles that often accompany remigration, planned and imagined as a ‘homecoming’, are seldom the topic of investigation in migration studies. Returning is not always an ‘easy game’. To explore this aspect of remigration, this chapter intends to focus on narratives of return produced mainly by so-called co-ethnic migrants who moved back to Croatia and the Czech Republic during the past two decades of post-socialist transformation. The empirical base of the chapter draws on the experiences and struggles accompanying remigration, and of arrival and acceptance in the respective society as described by returnees in biographical interviews. Attention is given to everyday social interaction …
‘Tool port’ to ‘landlord port’: a game theory approach to analyse gains from governance model transformation
2018
This study investigates potential port users’ surplus and terminal operators’ profits due to transforming port governance from the ‘tool port’ model to the ‘landlord port’ model. Although the landl...
Business Process Management in Financial and Non-Financial Institutions: Payment Process Modelling in Financial Flows Management
2017
Business process management is a progressively developing area of science, which is seen as the most modern and forward-looking innovative. Modern business operations remain highly dependent on IT solutions to steer the processes. Business process management solutions have been the clue for easing daily business operations. IT solutions have actively penetrated the working environment in all areas of business, especially the financial sector. It is beyond to imagine modern financial markets and institutions without IT software support. Not only billing, calculation and payment processes, even stock pricing, market analysis and risk monitor tools are fully computerized through business proce…
Stability of Asymmetric Lipid Bilayers Assessed by Molecular Dynamics Simulations
2009
The asymmetric insertion of amphiphiles into biological membranes compromises the balance between the inner and outer monolayers. As a result, area expansion of the receiving leaflet and curvature strain may lead to membrane permeation, shape changes, or membrane fusion events. We have conducted both atomistic and coarse-grained molecular dynamics simulations of dipalmitoyl-phosphatidylcholine (DPPC) bilayers to study the effect of an asymmetric distribution of lipids between the two monolayers on membrane stability. Highly asymmetric lipid bilayers were found to be surprisingly stable within the submicrosecond time span of the simulations. Even the limiting case of a monolayer immersed in …
On the Almost Everywhere Convergence of Multiple Fourier-Haar Series
2019
The paper deals with the question of convergence of multiple Fourier-Haar series with partial sums taken over homothetic copies of a given convex bounded set $$W\subset\mathbb{R}_+^n$$ containing the intersection of some neighborhood of the origin with $$\mathbb{R}_+^n$$ . It is proved that for this type sets W with symmetric structure it is guaranteed almost everywhere convergence of Fourier-Haar series of any function from the class L(ln+L)n−1.