Search results for " Transformation"
showing 10 items of 1043 documents
Transition to Digital Distribution Platforms and Business Model Evolution
2019
How do business models evolve when technology-based firms move from physical distribution channels to digital distribution platforms? This is an important question, since digitalization of distribution platforms provides new opportunities to expand the reach and customer base of technology-based firms. Based on an in-depth multi-case study of four Japanese high-tech firms, we seek to expand our understanding of digital transformation and business model literature. Our findings indicate that that through digital transformation, the case firms’ business models evolved toward more constant interaction with the market, in particular through digital platforms. This interaction includes growing a…
Agile Enterprise Transformations : Surveying the Many Facets of Agility for the Hybrid Era
2022
Agile companies are not uniform. Consequently, agile transformations are conceived broadly, ranging from adopting agile methods and practices in software development teams or functions to building all-encompassing enterprise agility. Moreover, the targeted effects of agility may vary, and the success of transformations and the attainment of agility are measured in various ways. In this paper, based on a recent industrial survey study, we scrutinize holistically why companies want to transform, what types of agility they are aiming at, and how they gauge transformations. The survey data was collected during the COVID-19 pandemic in 2020. Most of the respondents were in large or very large co…
Digikehitysjohtajan tehtävissä tarvittavat kompetenssit : laadullinen tutkimus
2017
Tämän tutkimuksen tarkoituksena on selvittää kirjallisuuskatsauksen ja empiirisen tutkimuksen avulla: mitä kompetensseja digikehitysjohtajan (eng. Chief Digital Officer, CDO) tehtävissä tarvitaan? Digitalisaatio on Mooren lain aikaansaama teknologian kehittymisen ilmiö, joka saa aikaan muutoksia, niin yksilö-, yritys- kuin yhteiskuntatasoilla. Yritysten näkökulmasta siihen liittyy keskeisesti digitaalinen transformaatio, jossa teknologian mahdollisuuksia pyritään hyödyntämään yrityksessä digitalisoinnin avulla. Digitaalinen transformaatio vaikuttaa yrityksiin monella tavalla, ja sen hyödyt ovat parhaiten nähtä-vissä asiakaskokemuksessa, prosesseissa ja liiketoimintamalleissa. Transformaatio…
Ledrappier-Young formula and exact dimensionality of self-affine measures
2017
In this paper, we solve the long standing open problem on exact dimensionality of self-affine measures on the plane. We show that every self-affine measure on the plane is exact dimensional regardless of the choice of the defining iterated function system. In higher dimensions, under certain assumptions, we prove that self-affine and quasi self-affine measures are exact dimensional. In both cases, the measures satisfy the Ledrappier-Young formula. peerReviewed
Mutant HRAS as novel target for MEK and mTOR inhibitors.
2015
HRAS is a frequently mutated oncogene in cancer. However, mutant HRAS as drug target has not been investigated so far. Here, we show that mutant HRAS hyperactivates the RAS and the mTOR pathway in various cancer cell lines including lung, bladder and esophageal cancer. HRAS mutation sensitized toward growth inhibition by the MEK inhibitors AZD6244, MEK162 and PD0325901. Further, we found that MEK inhibitors induce apoptosis in mutant HRAS cell lines but not in cell lines lacking RAS mutations. In addition, knockdown of HRAS by siRNA blocked cell growth in mutant HRAS cell lines. Inhibition of the PI3K pathway alone or in combination with MEK inhibitors did not alter signaling nor had an imp…
Alterations of panoramic radiomorphometric indices in children and adolescents with beta-thalassemia major: A fractal analysis study
2021
Background Beta-thalassemia major is an inherited disorder that can cause bone deformity and loss of bone mineral density. The objective of this study is to evaluate the cortical and trabecular mandibular bone morphology of children and adolescents who have beta-thalassemia major (ß-TM) using a fractal dimension (FD) analysis and different panoramic radiomorphometric indices with digital panoramic radiographic images (DPRIs). Material and Methods The study included 80 patients (with 40 patients each of ß-TM and control). The mandibular cortical width (MCW), panoramic mandibular index (PMI), mandibular cortical index (MCI), and simple visual estimation (SVE) were evaluated, and an FD analysi…
Opinion dynamics, stubbornness and mean-field games
2014
This paper studies opinion dynamics and stubbornness using mean-field game theory. Assuming an initial exponential density function and affine control policies we analyze under what conditions the Fokker-Planck equation returns an exponential density function over the horizon. Consensus and clusters formation are also studied.
Ri _ GENERAZIONI. Reversibili
2016
Vogliamo ora la maestria del “meccanico” in luogo di quella del “muratore”. Vogliamo architetti capaci di costruire mentre pensano a dover o poter smontare. Troppo spesso assistiamo alla supponenza di tanti manufatti che si arrogano il diritto di sentirsi immortali e invece sono solo premature obsolescenze non più governabili. I tempi di realizzazione dell’architettura contemporanea sono giurassici; spesso l’edificio non è ancora completato è già sono mutate le circostanze per cui lo si è voluto mentre stiamo riconoscendo di non potere più tornare indietro. L’architettura oggi non riesce più a stare al passo con le continue mutazioni che l’ambiente e la società impongono (ormai sempre più r…
Geometric Aspects of Thermodynamics
2016
This chapter deals with mathematical aspects of thermodynamics most of which will be seen to be primarily of geometrical nature. Starting with a short excursion to differentiable manifolds we summarize the properties of functions, of vector fields and of one-forms on thermodynamic manifolds. This summary centers on exterior forms over Euclidean spaces and the corresponding differential calculus. In particular, one-forms provide useful tools for the analysis of thermodynamics. A theorem by Caratheodory is developed which is closely related to the second law of thermodynamics. The chapter closes with a discussion of systems which depend on two variables and for which there is an interesting a…
Critiquing and Joining Intersections of Disaster, Conflict, and Peace Research
2020
AbstractDisaster research, conflict research, and peace research have rich and deep histories, yet they do not always fully intersect or learn from each other, even when they investigate if and how disasters lead to conflict or peace. Scholarship has tended to focus on investigating causal linkages between disaster (including those associated with climate change) and conflict, and disaster diplomacy emerged as a thread of explanatory research that investigates how and why disaster-related activities do and do not influence peace and conflict. However, definitive conclusions on the disaster-conflict-peace nexus have evaded scientific consensus, in part due to conceptual, methodological, and …