Search results for " Tuberculosis"

showing 10 items of 213 documents

Isolated Nodal TBC Reactivation in a Patient with Post-Thrombocythemia Myelofibrosis Treated with Ruxolitinib: Case Report and Review of the Literatu…

2021

Ruxolitinib side effects include the most frequent hematological toxicity along with a more recently evidenced immunosuppressive activity, interfering both with the innate and adaptive immunity, and several cases of reactivation of latent infections by opportunistic agents in patients in treatment with ruxolitinib have been published in the last years. Several pathophysiological mechanisms may explain an association between ruxolitinib and opportunistic infections. From what we know, the only case of an isolated lymph node TBC reactivation in a ruxolitinib-treated myelofibrosis (MF) patient was reported by Patil et al. in 2016 [Int J Med Sci Public Health. 2017;6(3):1]. Other 10 cases descr…

Oncologymedicine.medical_specialtyRuxolitinibConstitutional symptomsSettore MED/15 - Malattie Del SangueHematological toxicityInternal medicineDrug DiscoverymedicinePharmacology (medical)In patientMyelofibrosisProspective cohort studyLymph nodePharmacologybusiness.industryInfection Myelofibrosis Reactivation Tuberculosis Ruxolitinib TBCGeneral Medicinemedicine.diseaseInfectious Diseasesmedicine.anatomical_structureOncologySputummedicine.symptombusinessmedicine.drug
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Hemophagocytic syndrome in a patient with disseminated tuberculosis: a case report

2018

Hemophagocytic syndrome (HS) is a rare disorder of the immune system. It is characterized by fever, lymphadenopathy, hepatosplenomegaly, cytopenia and hyperferritinemia. The cause differs in each country suggesting a specific genetic background and epidemiology of infections, and it can be associated with malignant diseases. A rare cause of HS is tuberculosis (TB), we describe a case of HS associated with disseminated Mycobacterium tuberculosis (MT) infection in a patient from Sudan. He presented diarrhea, fever, pancytopenia, thickened and dilated bowel loops and lymph nodes enlargement at ultrasound and computed tomography scan. A bone marrow biopsy performed to rule out a lymphoma reveal…

Pathologymedicine.medical_specialtySettore MED/09 - Medicina InternaTuberculosisHepatosplenomegalyMycobacterium tuberculosis.lcsh:MedicineMycobacterium tuberculosiMycobacterium tuberculosisBiopsymedicineHemophagocytic lymphohistiocytosis disseminated tuberculosis; Hemophagocytic syndrome; Mycobacterium tuberculosis; Medicine (all)hemophagocytic lymphohistiocytosis disseminated tuberculosisCytopeniabiologymedicine.diagnostic_testbusiness.industryMedicine (all)lcsh:RGeneral Medicinebiology.organism_classificationmedicine.diseasePancytopeniaLymphomaBronchoalveolar lavageHemophagocytic lymphohistiocytosis disseminated tuberculosimedicine.symptombusinessHemophagocytic syndromeItalian Journal of Medicine
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Italian multicentre study found infectious and vaccine-preventable diseases in children adopted from Africa and recommends prompt medical screening

2018

AIM This study evaluated the prevalence of infectious diseases and immunisation status of children adopted from Africa. METHODS We studied 762 African children referred to 11 Italian paediatric centres in 2009-2015. Clinical and laboratory data were retrospectively collected and analysed. RESULTS The median age of the children (60.3% males) was 3 years and 6 months, 52.6% came from Ethiopia and 50.1% had at least one infectious disease. Parasitic infections accounted for the majority of the infectious diseases (409 of 715), and the most common were Giardia lamblia (n = 239), Toxocara canis (n = 65) and skin infections (n = 205), notably Tinea capitis/corporis (n = 134) and Molluscum contagi…

Pediatricsmedicine.medical_specialtyTuberculosisEpidemiologyParasitic infectionsPopulationSkin infectionPediatricsQuantiFERON03 medical and health sciences0302 clinical medicine030225 pediatricsmedicineTuberculosis030212 general & internal medicineeducationeducation.field_of_studybusiness.industryEpidemiology; Immunisation; International adoption; Parasitic infections; Tuberculosis; Pediatrics Perinatology and Child HealthEpidemiology; Immunisation; International adoption; Parasitic infections; TuberculosisGeneral MedicinePerinatology and Child Healthmedicine.diseaseInternational adoptionVaccinationImmunisationSettore MED/38 - PEDIATRIA GENERALE E SPECIALISTICAInfectious disease (medical specialty)Pediatrics Perinatology and Child HealthTinea capitisVaccine-preventable diseasesbusiness
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Severe tuberculous meningoencephalitis in a 30-year old woman with active systemic lupus erythematosus.

1997

Tuberculosis is a significant cause of morbidity and mortality in immunocompromising diseases such as systemic lupus erythematosus (SLE). It often is difficult to distinguish between central nervous system (CNS) involvement and infectious complications in SLE. We report the case of a 30-year-old woman with active SLE and severe tuberculous meningoencephalitis. The diagnosis of tuberculous meningoencephalitis was confirmed by cerebrospinal fluid culture examination, which revealed mycobacterium tuberculosis and typical findings for tuberculous meningoencephalitis on magnetic resonance imaging. Despite treatment with isoniazid, rifampicin, ethambutol, streptomycin, and prednisone, the patient…

Pediatricsmedicine.medical_specialtyTuberculosisbiologybusiness.industryIsoniazidmedicine.diseasebiology.organism_classificationTuberculous meningitisMycobacterium tuberculosisRheumatologyPrednisoneMedicineskin and connective tissue diseasesbusinessRifampicinEthambutolmedicine.drugAnti-SSA/Ro autoantibodiesJournal of clinical rheumatology : practical reports on rheumaticmusculoskeletal diseases
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Monocyte to lymphocyte blood ratio in tuberculosis and HIV patients: Comparative analysis, preliminary data

2017

Recent data confirmed the hypothesis suggested by historical studies that the ratio of peripheral blood monocytes to lymphocytes (M/L) is associated with the risk of tuberculosis (TB) disease. We retrospectively analyzed the electronic health records of tuberculosis and HIV-positive patients who had followed day-care programs at the AIDS Center of the University of Palermo, Italy. 261 patients were recruited and divided into 6 groups as follows: healthy control group (HCG: 47 pts), latent HIV negative infected TB group (LIG, 43 pts), active HIV negative tuberculosis (TAG: 61 pts), treated tuberculosis HIV negative (TTG: 44 pts), HIV drug-naive patients tested TST and QFT-IT-negative with ne…

PharmacologyCo-infected HIV/TBCTuberculosiDrug Discovery3003 Pharmaceutical ScienceCo-infected HIV/TBC; HIV infection; Monocyte to lymphocyte blood RATIO; Tuberculosis; Pharmacology; Drug Discovery3003 Pharmaceutical ScienceMonocyte to lymphocyte blood RATIOHIV infection
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Epidemiology of Mycobacterial Resistance(Especially <i>Mycobacterium tuberculosis</i>)

1999

Pharmacologymedicine.medical_specialtyTuberculosisbiologymedicine.drug_classbusiness.industryAntibioticsGeneral Medicinebiology.organism_classificationmedicine.diseaseMicrobiologyMycobacterium tuberculosisInfectious DiseasesOncologyDrug DiscoveryEpidemiologyImmunologymedicinePharmacology (medical)businessAntibacterial agentChemotherapy
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Comparative Proteomics of Activated THP-1 Cells Infected with Mycobacterium tuberculosis Identifies Putative Clearance Biomarkers for Tuberculosis Tr…

2015

Biomarkers for determining clearance of Mycobacterium tuberculosis (Mtb) infection during anti-tuberculosis therapy or following exposure could facilitate enhanced monitoring and treatment. We screened for biomarkers indicating clearance of Mtb infection in vitro. A comparative proteomic analysis was performed using GeLC MSI/MS. Intracellular and secreted proteomes from activated THP-1 cells infected with the Mtb H37Rv strain (MOI = 1) and treated with isoniazid and rifampicin for 1 day (infection stage) and 5 days (clearance stage) were analyzed. Host proteins associated with early infection (n = 82), clearance (n = 121), sustained in both conditions (n = 34) and suppressed by infection (n…

ProteomicsProteomeCell Line Tumorlcsh:Rlcsh:MedicineHumansTuberculosislcsh:QMycobacterium tuberculosislcsh:ScienceBiomarkersResearch ArticlePloS one
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Permanent Loss of Human Leukocyte Antigen E–restricted CD8+ T Stem Memory Cells in Human Tuberculosis

2022

Pulmonary and Respiratory MedicineHLA AntigensHLA-EClinical BiochemistryTuberculosisMycobacterium tuberculosisStem cellsCell BiologyCD8-Positive T-LymphocytesMolecular BiologyAmerican Journal of Respiratory Cell and Molecular Biology
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Host-directed therapies and holistic care for tuberculosis

2020

Pulmonary and Respiratory Medicinemedicine.medical_specialtyTuberculosisbusiness.industryAntitubercular AgentsMEDLINEHolistic HealthMycobacterium tuberculosisHolistic healthmedicine.diseaseHost-Pathogen InteractionsTuberculosis Multidrug-ResistantmedicineHumansIntensive care medicinebusinessHost (network)The Lancet Respiratory Medicine
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Human leucocyte antigen-A2 restricted and Mycobacterium tuberculosis 19-kDa antigen-specific CD8+ T-cell responses are oligoclonal and exhibit a T-ce…

2001

CD8+ T cells can be grouped into two different types of secretory T lymphocytes, based on the cytokine-secretion pattern upon antigen exposure: those with a T-cell cytotoxic type 1 response (Tc1), which secrete interferon-gamma (IFN-gamma), or those with a T-cell cytotoxic type 2 response, which secrete interleukin (IL)-4 and IL-10. We examined the CD8+ T-cell response directed against an immunodominant human leucocyte antigen (HLA)-A2-presented peptide derived from a 19-kDa Mycobacterium tuberculosis-associated antigen. T cells were examined by functional analysis and by T-cell receptor (TCR) complementarity-determining region 3 (CDR3)-spectratyping, which defines the complexity of a T-cel…

Receptors Antigen T-Cell alpha-betaT cellImmunologyHuman leukocyte antigenCD8-Positive T-LymphocytesBiologyLymphocyte ActivationEpitopeCell LineInterferon-gammaAntigenHLA-A2 AntigenmedicineHumansImmunology and AllergyCytotoxic T cellAntigen-presenting cellTuberculosis PulmonaryAntigens BacterialImmunodominant EpitopesT-cell receptorGranulocyte-Macrophage Colony-Stimulating FactorMycobacterium tuberculosisOriginal ArticlesComplementarity Determining RegionsMolecular biologyPeptide FragmentsClone Cellsmedicine.anatomical_structureImmunologyInterleukin-4CD8Immunology
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