Search results for " Tumor."

Enfermedad mínima residual y cáncer de mama en estadios iniciales: valor pronóstico de la detección de células tumorales diseminadas en médula ósea a…

2013

Introducción: La enfermedad mínima residual y en concreto la presencia de células tumorales diseminadas (CTD) en médula ósea constituye una variable con potencial valor pronóstico en cáncer de mama. Aunque existen estudios que evalúan el papel de la afectación de médula ósea por CTD en el momento del diagnóstico, el papel de esta determinación tras tratamiento con quimioterapia (QT) adyuvante es más controvertido. Hipótesis: La EMR tiene un impacto en supervivencia determinada al diagnóstico y tras quimioterapia en pacientes con cáncer de mama en estadios iniciales Objetivos: Los objetivos principales de nuestro estudio fueron: 1) identificar la proporción de afectación de médula ósea por c…

Early stage nasal vestibule tumors: safety and efficacy of HDR brachyterapy in elderly patients

2009

Adjuvant capecitabine in triple negative breast cancer patients with residual disease after neoadjuvant treatment: real-world evidence from CaRe, a m…

2023

BackgroundIn triple negative breast cancer patients treated with neoadjuvant chemotherapy, residual disease at surgery is the most relevant unfavorable prognostic factor. Current guidelines consider the use of adjuvant capecitabine, based on the results of the randomized CREATE-X study, carried out in Asian patients and including a small subset of triple negative tumors. Thus far, evidence on Caucasian patients is limited, and no real-world data are available.MethodsWe carried out a multicenter, observational study, involving 44 oncologic centres. Triple negative breast cancer patients with residual disease, treated with adjuvant capecitabine from January 2017 through June 2021, were recrui…

Neuroendocrine Tumors: A Comprehensive Review on Nutritional Approaches.

2022

Simple Summary Neuroendocrine neoplasms and their main subtype neuroendocrine tumors have an increasing incidence worldwide, associated with a high survival and prevalence rate. Both the tumor itself and systemic therapy can have an impact on patients' nutrition. Conversely, preliminary data suggest that malnutrition has a negative impact on the development and prognosis of neuroendocrine tumors, as does obesity. The aim of this review is to condense the latest evidence on the role of the most widely used dietary patterns, the Mediterranean diet, the ketogenic diet and intermittent fasting, in the context of neuroendocrine tumors. Nutritional plans are an integral part of the multidisciplin…

Targeting the tumor mutanome for personalized vaccination therapy

2012

Next generation sequencing enables identification of immunogenic tumor mutations targetable by individualized vaccines. In the B16F10 melanoma system as pre-clinical proof-of-concept model, we found a total of 563 non-synonymous expressed somatic mutations. Of the mutations we tested, one third were immunogenic. Immunization conferred in vivo tumor control, qualifying mutated epitopes as source for effective vaccines.

Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts

2014

The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF. The animals were vaccinated with free B16 cells or cell complexes. We employed two gene plasmid constructions: one high producer (pMok) and a low producer (p2F). Tumor transplant was performed by injection of B16 tumor cells. Plasma levels of total IgG and its subtypes were measured by ELISA. Tumor volumes were measured and survival curves were obtained. The study resulted in a cell complex vaccine able to stimulate the immune system to produce specific anti-tumor membrane proteins (TMP) IgG. In the g…

Intervención psicoeducativa en el alumnado con cáncer. Trayectoria profesional e investigadora en esta materia de la profesora Claudia Grau Rubio

2014

Se describe la trayectoria profesional e investigadora de la profesora Claudia Grau Rubio desde el año 1983,con respecto a la temática "intervención psicoeducativa en el alumnado con cáncer".

Paragangliomi cervicali: diagnosi e trattamento

2006

Potential use of organotin(IV)-tripetide complexes as stopper in tumor cells growth.

2008

Activation of the p38MAPK cascade is associated with upregulation of TNF alpha receptors in the spinal motor neurons of mouse models of familial ALS.

2005

Phosphorylated p38 mitogen-activated protein kinase (p38MAPK), but not activated c-jun-N-terminal kinase (JNK), increases in the motor neurons of transgenic mice overexpressing ALS-linked SOD1 mutants at different stages of the disease. This effect is associated with a selective increase of phosphorylated MKK3-6, MKK4 and ASK1 and a concomitant upregulation of the TNFalpha receptors (TNFR1 and TNFR2), but not IL1beta and Fas receptors. Activation of both p38 MAPK and JNK occurs in the activated microglial cells of SOD1 mutant mice at the advanced stage of the disease; however, this effect is not accompanied by the concomitant activation of the upstream kinases ASK1 and MKK3,4,6, while both …