Search results for " US"
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Los nuevos derechos sociales: El derecho al cuidado como fundamento del pacto constitucional
2016
ResumenNos encontramos ante un momento histórico y político que sugiere una revisión constitucional, con necesidades específicas y diferentes a las de 1978. Existen nuevas demandas que exigen que se revise el pacto constitucional. Algunas afectan directamente al catálogo de derechos, especialmente a los llamados derechos sociales, y se refieren por un lado, a la necesidad de otorgar a los derechos sociales ya reconocidos la consideración de fundamentales con todo lo que ello conlleva; y por otro, a la necesidad de crear nuevos derechos. El previsible aumento de personas necesitadas de cuidados, la escasez de servicios públicos para su asistencia, el tipo de cuidado informal prestado casi ex…
Obesity and survival in operable breast cancer patients treated with adjuvant anthracyclines and taxanes according to pathological subtypes: a pooled…
2013
Obesity is an unfavorable prognostic factor in breast cancer (BC) patients regardless of menopausal status and treatment received. However, the association between obesity and survival outcome by pathological subtype requires further clarification. METHODS: We performed a retrospective analysis including 5,683 operable BC patients enrolled in four randomized clinical trials (GEICAM/9906, GEICAM/9805, GEICAM/2003-02, and BCIRG 001) evaluating anthracyclines and taxanes as adjuvant treatments. Our primary aim was to assess the prognostic effect of body mass index (BMI) on disease recurrence, breast cancer mortality (BCM), and overall mortality (OM). A secondary aim was to detect differences o…
Vers un environnement informatisé d'évaluation de la qualité ergonomique d'interfaces multimédia : Étude exploratoire
2000
Our objective is to encourage the human-computer interface designers to be more interested in the uses made of their product by taking into account to a higher degree the human-factor in the testing phase which often is too focused on technical aspects. We want to facilitate the integration of the user as a source of evaluation during the testing phase. Our aim is to offer the designer a software environment of practical tests that allow them to have their own products evaluated by their users. We undertook an experiment to explore the feasibility of this project.
Vers un environnement informatisé d'évaluation de la qualité ergonomique d'interfaces multimédia : Étude exploratoire
2000
Our objective is to encourage the human-computer interface designers to be more interested in the uses made of their product by taking into account to a higher degree the human-factor in the testing phase which often is too focused on technical aspects. We want to facilitate the integration of the user as a source of evaluation during the testing phase. Our aim is to offer the designer a software environment of practical tests that allow them to have their own products evaluated by their users. We undertook an experiment to explore the feasibility of this project.
Brak sprzeczności planu miejscowego ze studium jako jedna z zasad sporządzania planu miejscowego
2022
Zagadnienie relacji między miejscowym planem zagospodarowania przestrzennego a studium uwarunkowań i kierunków zagospodarowania przestrzennego gminy stanowi przedmiot wieloletnich badań przedstawicieli nauki prawa, a także obszernych wypowiedzi sformułowanych w orzecznictwie. Wymóg, by plan miejscowy nie naruszał ustaleń studium, jest wymogiem ustawowym zawartym w przepisach art. 20 ust. 1 w zw. z art. 9 ust. 4 i art. 15 ust. 1 ustawy o planowaniu i zagospodarowaniu przestrzennym. Okoliczność, że w dalszym ciągu dochodzi do unieważnienia uchwał planistycznych w całości lub w części z powodu sprzeczności ze studium, wskazuje na aktualność tej problematyki oraz potrzebę dalszego popularyzowan…
Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry
2021
The formation of multiple proteoforms by post-translational modifications (PTMs) enables a single protein to acquire distinct functional roles in its biological context. Oxidation of methionine residues (Met) is a common PTM, involved in physiological (e.g., signaling) and pathological (e.g., oxidative stress) states. This PTM typically maps at multiple protein sites, generating a heterogeneous population of proteoforms with specific biophysical and biochemical properties. The identification and quantitation of the variety of oxidized proteoforms originated under a given condition is required to assess the exact molecular nature of the species responsible for the process under investigation…
Unraveling environmental histories from skeletal diaries — Advances in sclerochronology
2013
High-resolution proxy archives from aquatic settings are essential to better understand processes and mechanisms of global change. During the last decade, it has become increasingly evident that calcified tissues of bivalve mollusks and cold-water corals, in particular, can significantly increase our knowledge of seasonal to multi-decadal paleoclimate and paleoenvironmental variability in the extratropical oceans and coastal marine settings. Daily, tidal, fortnightly and annual growth patterns of periodically formed skeletal hard parts provide a means to place the proxy record in a precise temporal context. Their extreme longevity coupled with the running similarity between growth increment…