Search results for " Uncertainty"
showing 10 items of 777 documents
Automatic variable selection for exposure-driven propensity score matching with unmeasured confounders.
2020
Multivariable model building for propensity score modeling approaches is challenging. A common propensity score approach is exposure-driven propensity score matching, where the best model selection strategy is still unclear. In particular, the situation may require variable selection, while it is still unclear if variables included in the propensity score should be associated with the exposure and the outcome, with either the exposure or the outcome, with at least the exposure or with at least the outcome. Unmeasured confounders, complex correlation structures, and non-normal covariate distributions further complicate matters. We consider the performance of different modeling strategies in …
Marginal hazard ratio estimates in joint frailty models for heart failure trials
2019
Abstract This work is motivated by clinical trials in chronic heart failure disease, where treatment has effects both on morbidity (assessed as recurrent non‐fatal hospitalisations) and on mortality (assessed as cardiovascular death, CV death). Recently, a joint frailty proportional hazards model has been proposed for these kind of efficacy outcomes to account for a potential association between the risk rates for hospital admissions and CV death. However, more often clinical trial results are presented by treatment effect estimates that have been derived from marginal proportional hazards models, that is, a Cox model for mortality and an Andersen–Gill model for recurrent hospitalisations. …
The linear birth and death process under the influence of independently occurring disasters
1989
A population developing according to a time homogeneous linear birth and death process is subjected to an independently occurring random sequence of disasters. Using an embedded Galton-Watson process with random environments explicit results about the probability of extinction and the asymptotic behavior of the process are obtained.
Quantum dissipative dynamics of a bistable system in the sub-Ohmic to super-Ohmic regime
2016
We investigate the quantum dynamics of a multilevel bistable system coupled to a bosonic heat bath beyond the perturbative regime. We consider different spectral densities of the bath, in the transition from sub-Ohmic to super-Ohmic dissipation, and different cutoff frequencies. The study is carried out by using the real-time path integral approach of the Feynman-Vernon influence functional. We find that, in the crossover dynamical regime characterized by damped \emph{intrawell} oscillations and incoherent tunneling, the short time behavior and the time scales of the relaxation starting from a nonequilibrium initial condition depend nontrivially on the spectral properties of the heat bath.
Robust dynamic cooperative games
2009
Classical cooperative game theory is no longer a suitable tool for those situations where the values of coalitions are not known with certainty. Recent works address situations where the values of coalitions are modelled by random variables. In this work we still consider the values of coalitions as uncertain, but model them as unknown but bounded disturbances. We do not focus on solving a specific game, but rather consider a family of games described by a polyhedron: each point in the polyhedron is a vector of coalitions’ values and corresponds to a specific game. We consider a dynamic context where while we know with certainty the average value of each coalition on the long run, at each t…
Response functions in multicomponent Luttinger liquids
2012
We derive an analytic expression for the zero temperature Fourier transform of the density-density correlation function of a multicomponent Luttinger liquid with different velocities. By employing Schwinger identity and a generalized Feynman identity exact integral expressions are derived, and approximate analytical forms are given for frequencies close to each component singularity. We find power-like singularities and compute the corresponding exponents. Numerical results are shown for the case of three components.
A Stochastic Approach to Quantum Statistics Distributions: Theoretical Derivation and Monte Carlo Modelling
2009
Abstract. We present a method aimed at a stochastic derivation of the equilibrium distribution of a classical/quantum ideal gas in the framework of the canonical ensemble. The time evolution of these ideal systems is modelled as a series of transitions from one system microstate to another one and thermal equilibrium is reached via a random walk in the single-particle state space. We look at this dynamic process as a Markov chain satisfying the condition of detailed balance and propose a variant of the Monte Carlo Metropolis algorithm able to take into account indistinguishability of identical quantum particles. Simulations performed on different two-dimensional (2D) systems are revealed to…
Response models for mixed binary and quantitative variables
1992
SUMMARY A number of special representations are considered for the joint distribution of qualitative, mostly binary, and quantitative variables. In addition to the conditional Gaussian models and to conditional Gaussian regression chain models some emphasis is placed on models derived from an underlying multivariate normal distribution and on models in which discrete probabilities are specified linearly in terms of unknown parameters. The possibilities for choosing between the models empirically are examined, as well as the testing of independence and conditional independence and the estimation of parameters. Often the testing of independence is exactly or nearly the same for a number of di…
Flow of Homeomorphisms and Stochastic Transport Equations
2007
Abstract We consider Stratonovich stochastic differential equations with drift coefficient A 0 satisfying only the condition of continuity where r is a positive C 1 function defined on a neighborhood ]0, c 0] of 0 such that (Osgood condition), and s → r(s) is decreasing while s → sr(s 2) is increasing. We prove that the equation defines a flow of homeomorphisms if the diffusion coefficients A 1,…, A N are in . If , we prove limit theorems for Wong–Zakai approximation as well as for regularizing the drift A 0. As an application, we solve a class of stochastic transport equations.
Power of the Wilcoxon–Mann–Whitney test for non‐inferiority in the presence of death‐censored observations
2017
In clinical trials with patients in a critical state, death may preclude measurement of a quantitative endpoint of interest, and even early measurements, for example for intention-to-treat analysis, may not be available. For example, a non-negligible proportion of patients with acute pulmonary embolism will die before 30 day measurements on the efficacy of thrombolysis can be obtained. As excluding such patients may introduce bias, alternative analyses, and corresponding means for sample size calculation are needed. We specifically consider power analysis in a randomized clinical trial setting in which the goal is to demonstrate noninferiority of a new treatment as compared to a reference t…