Search results for " VIA"
showing 10 items of 388 documents
Cytoprotective Effects of Dinitrosyl Iron Complexes on Viability of Human Fibroblasts and Cardiomyocytes
2019
Nitric oxide (NO) is an important signaling molecule that plays a key role in maintaining vascular homeostasis. Dinitrosyl iron complexes (DNICs) generating NO are widely used to treat cardiovascular diseases. However, the involvement of DNICs in the metabolic processes of the cell, their protective properties in doxorubicin-induced toxicity remain to be clarified. Here, we found that novel class of mononuclear DNICs with functional sulfur-containing ligands enhanced the cell viability of human lung fibroblasts and rat cardiomyocytes. Moreover, DNICs demonstrated remarkable protection against doxorubicin-induced toxicity in fibroblasts and in rat cardiomyocytes (H9c2 cells). Data revealed t…
Effect of the oncolytic ECHO-7 virus Rigvir® on the viability of cell lines of human origin in vitro
2018
Background: The role of oncolytic viruses in cancer treatment is increasingly studied. The first oncolytic virus (Rigvir®, ECHO-7) was registered in Latvia over a decade ago. In a recent retrospective study Rigvir® decreased mortality 4.39-6.57-fold in stage IB-IIC melanoma patients. The aims of the present study are to test the effect of Rigvir® on cell line viability in vitro and to visualize the cellular presence of Rigvir® by immunocytochemistry. Methods: The cytolytic effect of Rigvir® on the viability of FM-9, RD, AGS, A549, HDFa, HPAF‑II, MSC, MCF7, HaCaT, and Sk-Mel-28 cell lines was measured using live cell imaging. PBMC viability was measured using flow cytometry. The presence of …
Yeasts and moulds contaminants of food ice cubes and their survival in different drinks
2018
Aims To evaluate the levels of unicellular and filamentous fungi in ice cubes produced at different levels and to determine their survival in alcoholic beverages and soft drinks. Methods and Results Sixty samples of ice cubes collected from home level (HL) productions, bars and pubs (BP) and industrial manufacturing plants (MP) were investigated for the presence and cell density of yeasts and moulds. Moulds were detected in almost all samples, while yeasts developed from the majority of HL and MP samples. Representative colonies of microfungi were subjected to phenotypic and genotypic characterization. The identification was carried out by restriction fragment length polymorphism (RFLP) ana…
Advanced fluorescence technologies help to resolve long-standing questions about microbial vitality
2012
International audience; Advances in fundamental physical and optical principles applied to novel fluorescence methods are currently resulting in rapid progress in cell biology and physiology. Instrumentation devised in pioneering laboratories is becoming commercially available, and study findings are now becoming accessible. The first results have concerned mainly higher eukaryotic cells but many more developments can be expected, especially in microbiology. Until now, some important problems of cell physiology have been difficult to investigate due to interactions between probes and cells, excretion of probes from cells and the inability to make in situ observations deep within the cell, w…
El papel de los servicios públicos en el desarrollo de áreas rurales: una perspectiva comparada
2010
El objetivo de la presente tesis es determinar el impacto que tienen los servicios y equipamientos públicos educativos y sanitarios elementales en los procesos de desarrollo rural. Ante la complejidad de dicho trabajo, y con el fin de conseguir unos resultados significativos y capaces de tomarse como posibles referencias, el estudio práctico se lleva a cabo en dos zonas rurales con marcados contrastes territoriales internos, pero de organización similar en cuanto a aspectos económicos, demográficos, políticos, etc. Así, por un lado se elige como área de estudio la Provincia de Valencia (Comunidad Valenciana, España); y por otro, se toma el Departamento de La Manche (Región de Baja Normandía…
El sistema distritual de innovación cerámico de Castellón
2010
Tesis Doctoral presentada por Daniel Gabaldón Estevan en el Instituto Interuniversitario de Desarrollo Local de la Universitat de València - Facultat de Geografia i Història.-- Distribuido bajo licencia Creative Commons de Reconocimiento-NoComercial 3.0 No adaptada
La nueva oportunidad de la hipoteca inversa
2021
The reverse mortgage is a credit or loan guaranteed by a mortgage that falls on the applicant?s habitual residence, granted at once, or through periodic benefits, to a person who must be over a certain age or prove a degree of disability or dependency, and is not due until the time of death. In view of the doubts that the future of the public pension is raising and the concentration of savings in Spanish property, the reverse mortgage is once again being put on the table as a viable alternative to complement a public pension with little revaluation, in view of the increase in life expectancy and expenses after retirement.
El viaje de Niclas Von Popplau por Europa (1483-1486)
2018
Peripecia y retórica del libro de viajes a Oriente
2019
Presentación del libro "Viajeros en China y libros de viajes a Oriente (entre la Edad Media y el siglo XVII)", que reúne 16 artículos de especialistas en la materia.
Las quejas de los viajeros: ¿un género digital para controlar la calidad de los servicios hoteleros?
2016
Analizamos las quejas de los viajeros en un corpus integrado por 80 opiniones o reseñas sobre cuatro hoteles, alojadas en la plataforma TripAdvisor en las categorías de puntuación “malo/pésimo” y “bueno/excelente”. El estudio se enmarca en el análisis del discurso interpersonal aplicado a géneros turísticos digitales (Mapelli 2008, 2016, Suau Jiménez 2011, 2012a, 2012b, 2014), con el propósito de caracterizar no solo el aspecto relacional entre autor y lector, sino también el proposicional. Nos centramos en las quejas, ya que constituyen una parte fundamental de las opiniones. Abordamos la construcción de la subjetividad en la voz de los viajeros a partir de la revisión de los marcadores de…