Search results for " VIA"
showing 10 items of 388 documents
Viability and integrity of cell present in particulate bone collected during the preparation of the implant site: a preliminary study
2014
Aim: The aim of this study was to evaluate viability and integrity of cells (Osteoblasts and Osteocytes) present in the particulate bone (Bone Chips), obtained during the preparation of the implant site. Methods: Four patients aged between the IV and the VI decade presenting edentulous areas class III of Cawood and Howell were selected. All patients suffering from systemic and oral diseases and smoking were excluded. The surgeries were performed with the conventional technique, full-thickness flap, and the implant sites were prepared with large coils calibrated burs mounted on surgical micromotor at a speed of 600 rpm and external irrigation of saline solution previously cooled . The partic…
Design of enzyme-mediated controlled release systems based on silica mesoporous supports capped with ester-glycol groups
2012
[EN] An ethylene glycol-capped hybrid material for the controlled release of molecules in the presence of esterase enzyme has been prepared. The final organic-inorganic hybrid solid S1 was synthesized by a two-step procedure. In the first step, the pores of an inorganic MCM-41 support (in the form of nanoparticles) were loaded with [Ru(bipy) 3]Cl 2 complex, and then, in the second step, the pore outlets were functionalized with ester glycol moieties that acted as molecular caps. In the absence of an enzyme, release of the complex from aqueous suspensions of S1 at pH 8.0 is inhibited due to the steric hindrance imposed by the bulky ester glycol moieties. Upon addition of esterase enzyme, del…
Tres conferències sobre el Tirant lo Blanch a València (1912, 1919 i 1921)
2017
Com a fruit de l’esforç de recuperació de les principals obres literàries medievals que durant la segona meitat del segle XIX portaren a terme els protagonistes de la Renaixença, entre els anys 1912 i 1921 a la ciutat de València se celebraren tres conferències que tingueren com a tema principal el Tirant lo Blanch, i que contribuïren notablement a divulgar la novel·la de Martorell entre les classes socials més actives, des d’un punt de vista intel·lectual i cívic. Així, cal assenyalar que, per aquells anys, el Tirant ja havia adquirit un gran simbolisme cultural i patriòtic per als valencians; i que, ben significativament, aquelles ponències –que varen ser organitzades per les entitats Lo …
Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics
2018
Abstract Multidrug-resistant bacterial infections are a global health threat. Nanoparticles are thus investigated as novel antibacterial agents for clinical practice, including wound dressings and implants. We report that nanoparticles' bactericidal activity strongly depends on their physical binding to pathogens, including multidrug-resistant primary clinical isolates, such as Staphylococcus aureus , Klebsiella pneumoniae or Enterococcus faecalis . Using controllable nanoparticle models, we found that nanoparticle-pathogen complex formation was enhanced by small nanoparticle size rather than material or charge, and was prevented by 'stealth' modifications. Nanoparticles seem to preferentia…
Interaction effects of enniatin B, deoxinivalenol and alternariol in Caco-2 cells.
2015
Enniatin B (ENN B), deoxinivalenol (DON) and alternariol (AOH) are secondary metabolites of filamentous fungi. These mycotoxins are contaminants of vegetables and cereals. They are cytotoxic and their effects are enhanced by their mixtures. The objectives of this study were to compare the cytotoxicity of ENN B, DON and AOH alone or in combination in human adenocarcinoma (Caco-2) cells and to evaluate the type of interactions of mycotoxin mixtures by the isobologram analysis. Cells were treated with concentrations ranging from 1.85 to 90μM (AOH) and from 0.312 to 10μM (for ENN B and DON), individually and in combination of two and three mycotoxins (from 1.85 to 30μM for AOH and from 0.312 to…
Evaluación de los factores de riesgo, comportamientos y accidentalidad vial de los usuarios vulnerables: el caso de los ciclistas = Assessment of the…
2018
Aunque los accidentes de tráfico constituyen desde hace décadas un serio problema de salud pública, la alta vulnerabilidad de grupos de usuarios específicos -entre ellos los ciclistas- ha dado lugar a una especial preocupación a nivel social, político y científico a lo largo del último lustro. Además, la evidencia reciente sugiere que durante los próximos años la utilización de la bicicleta como medio transporte urbano aumentará sustancialmente, lo que dará lugar también a un incremento de las lesiones y muertes entre los usuarios de este sistema de movilidad. En este contexto, uno de los factores con mayor peso explicativo de la siniestralidad vial es el comportamiento de los usuarios; sin…
Viable Systems Approach and Consumer Culture Theory: A Conceptual Framework
2013
The aim of this study is to depict the relational dynamics between the firm/ brand and the individual/consumer or communities of consumers. To this aim we propose a conceptual framework, integrating the viable systems approach (VSA) with consumer culture theory (CCT), which considers the individual as an active co-maker of the product/brand (‘prosumer’). The VSA view of the firm overcomes the limitations of CCT research, which is mainly focused on the individual, giving little consideration to the other actors in the context. Among the different approaches under the umbrella of viable systems we chose the VSA because of its emphasis on the analysis of the systemic external relations with th…
Degraded Gerber Saddles in RC Bridges
2023
Sudden failure of reinforced concrete (RC) or prestressed concrete (PC) Gerber saddles of bridges and viaducts has occurred all around in the word in the last few years due to corrosion of steel bars. The danger of sudden and brittle failure is often due to general and pitting corrosion of steel bars, concrete crushing, and loss of bond in steel bars. In this paper, the flexural response of reinforced concrete Gerber supports under their self-weight with or without service loads was investigated through determination of the load-deflection response of beams, with the focus on the consequences of pitting corrosion and loss of bond in steel bars. A simplified strut-and-tie model was developed…
Cell inactivation and membrane damage after long-term treatments at sub-zero temperature in the supercooled and frozen states.
2008
The survival of cells subjected to cooling at sub-zero temperature is of paramount concern in cryobiology. The susceptibility of cells to cryopreservation processes, especially freeze-thawing, stimulated considerable interest in better understanding the mechanisms leading to cell injury and inactivation. In this study, we assessed the viability of cells subjected to cold stress, through long-term supercooling experiments, versus freeze-thawing stress. The viability of Escherichia coli, Saccharomyces cerevisiae, and leukemia cells were assessed over time. Supercooled conditions were maintained for 71 days at -10 degrees C, and for 4 h at -15 degrees C, and -20 degrees C, without additives or…
Ovarian tissue cryopreservation and transplantation in menopause: new perspective of therapy in postmenopausal women and the importance of ethical an…
2023
Menopausal transition entails a progressive decrease in hormone production by the ovaries that lead to important physical and psychological changes that could significantly affect quality of life. Hormone replacement therapy (HRT) administered from the onset of menopausal symptoms usually improves quality of life and life expectancy. Nevertheless, it is not risk-free. Ovarian tissue cryopreservation (OTC) has been investigated as a potential new strategy for delaying menopause and/or to avoid HRT. This review analyzes the critical points of HRT to assess whether OTC and subsequent reimplantation can affect postmenopausal management. We assessed available randomized clinical trials in PubMed…