Search results for " Variant"
showing 10 items of 231 documents
RNA-Binding Proteins which interact with mRNAs for H1° and H3.3 histone variants
2014
P04.29: Is the finding of a central gall bladder an anatomic variant?
2005
Replication-independent expression of H1˚ and H3.3 histone variants is probably regulated by different RNA-binding proteins
2012
DNA in eukaryotes is wrapped around core histones to form nucleosomes, the basic units of chromatin. The linker histones H1 bind DNA where it enters and leaves the nucleosome, thus stabilizing higher order structures. Chromatin is a dynamic complex, modulated by different processes such as DNA-methylation, post-translational modifications of histones, and incorporation of specific histone variants. Throughout rat brain development, expression of H1° and H3.3 histone variants is mainly regulated at the post-transcriptional level. These proteins are of interest for their possible involvement in the replication-independent chromatin remodelling induced by extracellular stimuli. We previously c…
Histone H1° and H3.3 RNA-binding proteins identified in the developing rat brain
2011
Expression and intracellular localization of H1° mRNA-containing complexes in developing rat brain and astrocytes
2015
INTRODUCTION: Post-transcriptional regulation of gene expression relies on RNA-binding proteins (RBPs), which regulate intracellular transport, stability, and translation of mRNAs [1]. We previously identified a set of proteins which interact with mRNAs encoding H1° and H3.3 histones [2-5]. All these proteins are probably part of a ribonucleoprotein particle [6]. Here we report more details on the expression and intracellular localization of some of these RBPs, during rat brain development and in isolated rat astrocytes. METHODS: Affinity chromatography was performed as already described [6]. Preparation of total lysates and cellular sub-fractions was done as reported in [3]. Possible co-lo…
Histone H1° RNA-binding proteins in developing rat brain.
2011
Copy Number Variants and microRNAs in Autism Spectrum Disorders: a whole-genome analysis
2014
In recent years, there has been an increased interest by the scientific community on Autism Spectrum Disorders (ASDs), neurodevelopmental disorders of childhood with an incidence of about 1/160 children [1]. Different studies have indicated a strong genetic basis for autism susceptibility, also supported by the presence of autistic features in several monogenic disorders (e.g.,Fragile X syndrome, Tuberous sclerosis). Since 2007 Copy Number Variants (CNVs) were recognized as important genetic factors in ASD [2]. Studies performed so far have highlighted the pathogenic role of CNVs in terms of dosage change for protein-coding genes and few works have suggested the potential involvement of miR…
ALLELIC VARIANTS OF CYP2E1 GENE IN HEPATOCARCINOMA PATIENTS AND IN HEPATIC TUMOR CELL LINES
2011
Background and Aims: Hepatic enzyme CYP2E1 is involved in the metabolism of a number of exogenous and endogenous substances (i.e. ethanol, drugs and chemical carcinogens). Being polymorphic, CYP2E1 gene can give different xeno-metabolic capabilities in a population and it is well known that inadequate or no enzymatic deactivation of xenobiotics could induce an increased susceptibility to disease and cancer. In particular, one of the 5 -flanking region polymorphisms, able to differentiate CYP2E1 gene transcriptional activity, is caused by the appearance/disappearance of RsaI and PstI restriction sites, which generates two different alleles, namely *C1(Rsa+/Pst−) and *C2(Rsa−/Pst+) respective…
Torre del Greco, villa marittima in contrada Sora: 65. Statua di Satiro
2019
Si presenta il più noto reperto scultoreso dalla Villa di Contrada Sora a Torre del Greco, sondata per cunicoli dall'allora principe ereditario della dinastia borbonica, al cui seguito il reperto giunse a Palermo all'epoca della fuga della famiglia reale per l'avanzata francese. Il Satiro, una delle migliori repliche del celeberrimo Satiro Versante di Prassitele, consente di individuare alcune specificità della rielaborazione copistica rispondenti al gusto del facoltoso committente della costa vesuviana.
Introduzione a Silvana Grasso, Enrichetta
2016
Anamnesi di un’analoga ossessione è questo volume. Quattro Enrichette, specchio biografico di un’identità impossibile da definire, si susseguono nella scrittura di Silvana Grasso, portando alla riemersione le «cellule staminali» di un mito metamorfico che condanna il personaggio da un lato all’eccezionalità e dall’altro alla solitudine. Quattro forme testuali per riaccendere un ricordo aurorale: un essere anfibio, di confine, metamorfico per natura e/o per scelta, che vive l’essere per sé sul crinale dell’essere per gli altri, che rappresenta, senza sottoporre ad alcun giudizio morale, ciò che l’umanità ‘normale’ rifugge e contemporaneamente cerca.