Search results for " Well-Being"
showing 10 items of 797 documents
Subjective well-being key elements of Successful Aging: A study with Lifelong Learners older adults from Costa Rica and Spain.
2019
Abstract Subjective well-being is a major psychological construct in the research tradition. Along with literature, authors have distinguished between hedonic and eudaimonic well-being. The aim of this study is to determine the role of some psychosocial variables plays in the perceived well-being is conceived from a hedonic or a eudaimonic perspective. The sample consisted of 1016 people of 55 years and older in a Spanish sample and 277 people of 55 years old or older from a Costa Rican sample. Both samples were part of the Longitudinal Older Learners (LOL) study. A structural model with latent variables was estimated with Mplus. The results point out that, the traditional variables include…
Do aging employees benefit from self-regulative strategies? : A follow-up study
2020
SOC-strategies (selection, optimization, and compensation) are crucial for well-being and adaptation throughout the life course. The workforce is aging rapidly, thus the age-conditional premises of SOC theory require attention. This study explored (1) whether older employees used SOC strategies more often (compared to younger employees), and (2) whether older employees benefited more from SOC strategies in relation to occupational well-being (job burnout, work engagement). The study was based on follow-up data including three occupational subsamples of different age (N = 1,020). There were no significant age-conditional differences in the take-up of SOC strategies. However, older (white-col…
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
2021
Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci ass…
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness…
2011
Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions a…
Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults
2020
Abstract Background In 2016, an expert working group was convened under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and formulated consensus recommendations for the conduct of clinical trials for drugs to prevent or treat sarcopenia. Aims The objective of the current paper is to provide a 2020 update of the previous recommendations in accordance with the evidence that has become available since our original recommendations. Methods This paper is based on literature reviews performed by members of the ESCEO working group and followed up with face to face meetings organized for the whole group to make amendments and discuss…
The age and well-being “paradox”: a longitudinal and multidimensional reconsideration
2022
This paper explores qualifcations to the much-discussed paradox that although aging is associated with multiple physical and social losses, subjective well-being (SWB) is stable or increasing in later life. We explore age-related changes in cognitive, afective, and eudaimonic dimensions in three waves of data spanning up to 15 years from the Norwegian NorLAG study (N=4,944, age 40−95). We employ fxed-efect models to examine the nature and predictors of aging efects on SWB. Results indicate a general pattern of stability well into older age, but negative changes in advanced age across well-being measures. Declines in SWB are less pronounced and with a later onset for the cognitive compared w…
Receptor Activator of NF-kB (RANK) Expression in Primary Tumors Associates with Bone Metastasis Occurrence in Breast Cancer Patients
2011
Background\ud Receptor activator of NFkB (RANK), its ligand (RANKL) and the decoy receptor of RANKL (osteoprotegerin, OPG) play a pivotal role in bone remodeling by regulating osteoclasts formation and activity. RANKL stimulates migration of RANK-expressing tumor cells in vitro, conversely inhibited by OPG.\ud \ud Materials and Methods\ud We examined mRNA expression levels of RANKL/RANK/OPG in a publicly available microarray dataset of 295 primary breast cancer patients. We next analyzed RANK expression by immunohistochemistry in an independent series of 93 primary breast cancer specimens and investigated a possible association with clinicopathological parameters, bone recurrence and surviv…
Collecting and Using Students’ Digital Well-Being Data in Multidisciplinary Teaching
2018
This article examines how students (N=198; aged 13 to 17) experienced the new methods for sensor-based learning in multidisciplinary teaching in lower and upper secondary education that combine the use of new sensor technology and learning from self-produced well-being data. The aim was to explore how students perceived new methods from the point of view of their learning and did the teaching methods provide new information that could promote their own well-being. We also aimed to find out how to collect digital well-being data from a large number of students and how the collected big data set can be utilized to predict school success from the students’ well-being data by using machine lear…
When Climate Turns Nasty, What Are Recent and Future Implications? Ecological and Human Health Review of Climate Change Impacts
2020
Purpose of Review: The impacts of climate change on biodiversity in the last three decades have increasingly assumed from significant to threatening proportions and this causes major global concerns. This study aims at examining the recent and future impacts of global climate change on both ecological resources and human well-being. This review study is based on the general concept of ecological resilience: that coping with climate change stresses and disturbances depends on social resilience, political and environmental strategies accessible in a community. The study assessed over 300 peer-reviewed publications, both articles and books, which linked climate change impacts on ecosystems to …