Search results for " acetonitrile"

showing 10 items of 628 documents

The deubiquitinase USP11 is a versatile and conserved regulator of autophagy

2021

Autophagy is a major cellular quality control system responsible for the degradation of proteins and organelles in response to stress and damage to maintain homeostasis. Ubiquitination of autophagy-related proteins or regulatory components is important for the precise control of autophagy pathways. Here, we show that the deubiquitinase ubiquitin-specific protease 11 (USP11) restricts autophagy and that KO of USP11 in mammalian cells results in elevated autophagic flux. We also demonstrate that depletion of the USP11 homolog H34C03.2 in Caenorhabditis elegans triggers hyperactivation of autophagy and protects the animals against human amyloid-β peptide 42 aggregation-induced paralysis. USP11…

autophagyhAβ42 human amyloid-β protein 1 to 42Lipid kinase activityPI(3)P phosphatidylinositol-3-phosphatemTORC1BiochemistryCell LineGene Knockout Techniqueschemistry.chemical_compoundubiquitinAnimalsHumansULK1 unc-51-like autophagy activating kinase 1WIPI WD-repeat domain phosphoinositide-interacting proteinPI3KC3-C1Caenorhabditis elegansCaenorhabditis elegans ProteinsmTORC1Molecular BiologyMechanistic target of rapamycinUSP11 ubiquitin-specific protease 11proteostasisAmyloid beta-PeptidesS6K S6 kinasebiologyPhosphatidylinositol 3-phosphateAutophagyDUB deubiquitinaseLFQ label-free quantificationIP immunoprecipitationNHT nonhuman targetingPI3KC3-C1 class III phosphatidylinositol 3-kinase complex ICell BiologyACN acetonitrileAβ amyloid-βNRBF2 nuclear receptor-binding factor 2Peptide FragmentsCell biologydeubiquitinase (DUB)ProteostasischemistryProteotoxicitymTORC1 mechanistic target of rapamycin complex 1biology.proteinAutophagy-Related Protein-1 HomologBSA bovine serum albuminThiolester HydrolasesResearch ArticleJournal of Biological Chemistry
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CCDC 1852850: Experimental Crystal Structure Determination

2019

Related Article: Qiang Chen, Stefan Thoms, Sven Stöttinger, Dieter Schollmeyer, Klaus Müllen, Akimitsu Narita, Thomas Basché|2019|J.Am.Chem.Soc.|141|16439|doi:10.1021/jacs.9b08320

benzo[a]dinaphtho[218-cde:1'2'3'4'-ghi]perylene-514-dicarbaldehyde acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 829874: Experimental Crystal Structure Determination

2012

Related Article: R.Inglis, E.Houton, Junjie Liu, A.Prescimone, J.Cano, S.Piligkos, S.Hill, L.F.Jones, E.K.Brechin|2011|Dalton Trans.|40|9999|doi:10.1039/c1dt11118c

bis((mu~3~-((Hydroxyimino)(phenyl)methyl)phenolato)-(mu~2~-pyridin-2-ylmethanolato))-tetrakis(2-((hydroxyimino)-(phenyl)methyl)phenolato)-di-manganese-di-zinc acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 267737: Experimental Crystal Structure Determination

2005

Related Article: M.Cametti, M.Nissinen, A.D.Cort, L.Mandolini, K.Rissanen|2005|J.Am.Chem.Soc.|127|3831|doi:10.1021/ja042807n

bis((mu~3~-NN'-o-Phenylenebis(3-(benzyloxy)salicylideneaminato))-(mu~3~-chloro)-(mu~3~-oxo)-oxo-cesium-uranium) acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 267736: Experimental Crystal Structure Determination

2005

Related Article: M.Cametti, M.Nissinen, A.D.Cort, L.Mandolini, K.Rissanen|2005|J.Am.Chem.Soc.|127|3831|doi:10.1021/ja042807n

bis((mu~3~-NN'-o-Phenylenebis(3-(benzyloxy)salicylideneaminato))-(mu~3~-fluoro)-(mu~3~-oxo)-oxo-cesium-uranium) acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1876390: Experimental Crystal Structure Determination

2019

Related Article: Steffen Treiling, Cui Wang, Christoph Fçrster, Florian Reichenauer, Jens Kalmbach, Pit Boden, Joe P. Harris, Luca M. Carrella, Eva Rentschler, Ute Resch-Genger, Christian Reber, Michael Seitz, Markus Gerhards, and Katja Heinze|2019|Angew.Chem.,Int.Ed.|58|18075|doi:10.1002/anie.201909325

bis(22'2''-(ethane-111-triyl)tripyridine)-chromium tris(hexafluorophosphate) acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 1876389: Experimental Crystal Structure Determination

2019

Related Article: Steffen Treiling, Cui Wang, Christoph Fçrster, Florian Reichenauer, Jens Kalmbach, Pit Boden, Joe P. Harris, Luca M. Carrella, Eva Rentschler, Ute Resch-Genger, Christian Reber, Michael Seitz, Markus Gerhards, and Katja Heinze|2019|Angew.Chem.,Int.Ed.|58|18075|doi:10.1002/anie.201909325

bis(22'2''-(ethane-111-triyl)tris(pyridine))-chromium tris(tetrafluoroborate) acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 736124: Experimental Crystal Structure Determination

2010

Related Article: R.Ballesteros-Garrido, B.Abarca, R.Ballesteros, C.R.de Arellano, F.R.Leroux, F.Colobert, E.Garcia-Espana|2009|New J.Chem.|33|2102|doi:10.1039/b906992e

bis(33'-(pyridine-26-diyl)bis[123]triazolo[15-a]pyridine)-zinc(ii) diperchlorate acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 889025: Experimental Crystal Structure Determination

2015

Related Article: A. R. Popescu, I. Rojo, F. Teixidor, R. Sillanpää, C. Viñas|2015|Chem.-Eur.J.|21|8613|doi:10.1002/chem.201500307

bis(78-bis(diisopropylphosphino)-78-dicarba-nido-undecaborane)-aqua-magnesium acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 829482: Experimental Crystal Structure Determination

2012

Related Article: D.Armentano, J.Martinez-Lillo|2012|Inorg.Chim.Acta|380|118|doi:10.1016/j.ica.2011.09.010

bis(Dichloro-bis(ethane-12-diamine)-ruthenium(iii)) hexachloro-rhenium(iv) acetonitrile solvateSpace GroupCrystallographyCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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