Search results for " activity"
showing 10 items of 4540 documents
Effect of a dominant-negative form of ADAM10 in a mouse model of Alzheimer's disease.
2009
The alpha-secretase cleaves in the non-amyloidogenic pathway the amyloid-beta protein precursor (AbetaPP) within the region of the amyloid-beta peptides to prevent their formation and aggregation in the brain. Members of the ADAM family (a disintegrin and metalloprotease) are the main candidates for physiologically relevant alpha-secretases. We recently demonstrated that overexpression of ADAM10 in mice transgenic for human AbetaPP (ADAM10 x APP[V717I]) alleviated functional deficits related to Alzheimer's disease. To further demonstrate that this is due to the specific activity of alpha-secretase, we characterized mice overexpressing an inactive form of ADAM10 (ADAM10[E384A]; ADAM10-dn). T…
Feasibility of a Responsibility-Based Leadership Training Program for Novice Physical Activity Instructors
2021
Most coaches and instructors would like to teach more than just sport skills to their athletes and children. However, to promote athletes' or children's holistic development and teach them to take responsibility and lead, requires the coaches and instructors to first master the skills themselves. Therefore, feasible, high quality leadership training programs where coaches and physical activity instructors are taught to teach and share leadership are needed. The aim of the current study was to evaluate the feasibility of a leadership training program to optimize it and to determine whether to proceed with its evaluation. In the leadership training program, eight Finnish novice physical activ…
Microbiology and atmospheric processes: research challenges concerning the impact of airborne micro-organisms on the atmosphere and climate
2011
Cet article a fait l'objet d'une discussion dans "Morris, C. E., Sands, D. C., Bardin, M., Jaenicke, R., Vogel, B., Leyronas, C., Ariya, P. A., and Psenner, R.: Microbiology and atmospheric processes: an upcoming era of research on bio-meteorology, Biogeosciences Discuss., 5, 191-212, doi:10.5194/bgd-5-191-2008, 2008."; International audience; For the past 200 years, the field of aerobiology has explored the abundance, diversity, survival and transport of micro-organisms in the atmosphere. Micro-organisms have been explored as passive and severely stressed riders of atmospheric transport systems. Recently, an interest in the active roles of these micro-organisms has emerged along with prop…
Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.
2022
Funder: European Commission
Synthesis, Structural Analysis, Fiber Formation and Preliminary Anticancer Characterization of the Organotin Polyether from Dibutyltin Dichloride and…
2012
The organotin polyether derived from reaction of dibutyltin dichloride and 2,5-dimethyl-3-hexyne-2,5-diol was rapidly synthesized employing classical interfacial polymerization in 65% yield and a chain length of 360 units. IR results are consistent with the polyether structure. Bands characteristic of the formation of the Sn-O are present and bands characteristic of the Sn-Cl are absent. F MALDI MS results in the low mass range gives ion fragment clusters to five units. Isotopic abundance matches for tin are consistent with its presence in these ion fragment clusters. In the high mass range ion fragment clusters to greater than 300 units are found. The products offer outstanding inhibition …
Tricyclic heterocycles with antiproliferative activity
2009
SYNTHESIS AND ANTITUMOR ACTIVITY OF NEW PYRROLO[2,1-c][1,4]BENZOXAZINES
2009
Stabilized Naked Sub-nanometric Cu Clusters within a Polymeric Film Catalyze C-N, C-C, C-O, C-S, and C-P Bond-Forming Reactions
2015
[EN] Sub-nanometric Cu clusters formed by endogenous reduction of Cu salts and Cu nanoparticles are active and selective catalysts for C−N, C−C, C−O, C−S, and C−P bond-forming reactions. Sub-nanometric Cu clusters have also been generated within a polymeric film and stored with full stability for months. In this way, they are ready to be used on demand and maintain high activity (TONs up to 104 ) and selectivity for the above reactions. A potential mechanism for the formation of the sub-nanometric clusters and their electronic nature is presented.
AZAINDOLO-FUSED HETEROCYCLES: SYNTHESIS AND ANTITUMOR ACTIVITY
2008
La educación para la salud en la escuela en la adquisicion de estilos de vida saludables
2013
ABSTRACT: The main objective of ESP is to develop activities and encourage the students to achieve the highest attainable standard of health, through the acquisition of knowledge and skills that promote choice and adoption of healthy lifestyles, seeking the participation, the interaction and social integration and the ability to work critically and creatively, and the search for solutions. Promotion and Health Education developed from Schools is one of the key tools of health interventions. Access to children and young people is almost complete because of the obligatory education. In the period of the obligatory people education are more receptive for the learning, being the period of the v…