Search results for " activity"
showing 10 items of 4540 documents
New Optically Active 4-Alkoxyprolinol Ethers Derived from trans-4-Hydroxy-L-proline
2011
(2S,4R)-trans-4-Hydroxy-L-proline has been used as thechiral-pool source in the efficient syntheses of optically active protected 4-hydroxyprolinols. After N-acyl protection andester formation, the first ether moiety was introduced maintaining the chiral centre adjacent to the ester. Then, reduction of the ester delivered the corresponding carbinol, which had to be alkylated selectively to avoid side reactions with the N-protecting group. Finally, the N-acyl function was removed to generate the target methyl and tert-butyl ethers displaying defined substitution patterns. The so-formed optically active 4-alkoxyprolinol ethers can be used as core fragments in biologically active compounds or …
Novel Lymphocyte-Independent Antitumor Activity by PD-1 Blocking Antibody against PD-1+ Chemoresistant Lung Cancer Cells
2022
Abstract Purpose: Antibodies against the lymphocyte PD-1 (aPD-1) receptor are cornerstone agents for advanced non–small cell lung cancer (NSCLC), based on their ability to restore the exhausted antitumor immune response. Our study reports a novel, lymphocyte-independent, therapeutic activity of aPD-1 against NSCLC, blocking the tumor-intrinsic PD-1 receptors on chemoresistant cells. Experimental Design: PD-1 in NSCLC cells was explored in vitro at baseline, including stem-like pneumospheres, and following treatment with cisplatin both at transcriptional and protein levels. PD-1 signaling and RNA sequencing were assessed. The lymphocyte-independent antitumor activity of aPD-1 was explored in…
Associations of age, body size, and maturation with physical activity intensity in different laboratory tasks in children
2021
We investigated the associations of age, sex, body size, body composition, and maturity with measures of physical activity (PA) intensity in children. PA intensity was assessed using VO2 as % of VO2reserve or VO2 at ventilatory threshold (VT), muscle activity measured by textile electromyography, mean amplitude deviation (MAD) measured by accelerometry, and metabolic equivalent of task (MET) during laboratory activities.Age, stature, and muscle mass were inversely associated with VO2 as % of VO2reserve and % of VT, during walking or running on a treadmill for 4, 6, and 8 km/h (Spearman r = -0.645 to -0.358). Age was inversely associated with MAD during walking on treadmill for 4 km/h (r = -…
Body mass index in the early years in relation to motor coordination at the age of 5–7 years
2017
Physical activity (PA) and body mass index (BMI) are consistently associated with motor coordination (MC) in children. However, we know very little how BMI in early childhood associates with MC later in childhood. This study investigated associations between BMI in early childhood and BMI, PA, and MC in middle childhood. Children aged 5 to 7 years (n = 64, 32 girls) were measured for MC using Körperkoordinationstest für Kinder (KTK) and for moderate-to-vigorous PA (MVPA) using triaxial accelerometers. Prevailing body weight and height were measured, and information on weight and height in early years was based on parental report of child health care report cards. Age-adjusted BMIz scores we…
Jaunākā pirmsskolas vecuma bērnu vārdu krājuma bagātināšana didaktiskajās rotaļās
2018
Bakalaura darba tēma – “Jaunākā pirmsskolas vecuma bērnu vārdu krājuma bagātināšana didaktiskajās rotaļās”. Bakalaura darba autore: Indra Tišanova. Izvēlētās tēmas aktualitāte pamatojama ar to, ka didaktiskās rotaļas pirmsskolas vecuma bērniem rada patīkamas izjūtas, veicina sadarbības un citas nepieciešamās prasmes, tādēļ svarīgi izpētīt, kā ar rotaļu palīdzību var bagātināt bērnu vārdu krājumu. Pētījuma mērķis – teorētiski un praktiski izzināt vārdu krājuma bagātināšanas iespējas didaktiskajās rotaļās jaunākā pirmsskolas vecuma bērniem. Pētījums sastāv no divām daļām – teorētiskā un empīriskā pētījuma. Teorētiskajā daļā pētīti un izzināti latviešu un ārvalstu pedagoģijas un psiholoģijas p…
Daily physical activity and physical activity in soccer practice with children
2017
Päivittäisen fyysisen aktiivisuuden määrässä ja intensiteetissä on eroja ihmisten välillä. Suurin osa fyysisestä aktiivisuudesta tapahtuu vapaa-ajalla, lapsilla koulupäivän ulkopuolella. Liikuntasuositukset ohjeistavat riittävästä päivittäisen fyysisen aktiivisuuden määrästä ja laadusta. Yhä useammat lapset eivät saavuta näitä suosituksia ja jako aktiivisiin ja vähemmän aktiivisiin lapsiin on tullut entistä selkeämmäksi. Osallistumista ohjattuun liikuntaan on pidetty yhtenä ratkaisuna lisätä lasten päivittäisen fyysisen aktiivisuuden määrää. Tutkimukset kuitenkin ovat osoittaneet, ettei järjestettyyn liikuntaan osallistuminen kasvata lasten kokonaisaktiivisuutta. Saman päivän aikana tapahtu…
A family based tailored counselling to increase non-exercise physical activity in adults with a sedentary job and physical activity in their young ch…
2011
Background. Epidemiological evidence suggests that decrease in sedentary behaviour is beneficial for health. This family based randomized controlled trial examines whether face-to-face delivered counselling is effective in reducing sedentary time and improving health in adults and increasing moderate-to-vigorous activities in children. Methods. The families are randomized after balancing socioeconomic and environmental factors in the Jyväskylä region, Finland. Inclusion criteria are: healthy men and women with children 3-8 years old, and having an occupation where they self-reportedly sit more than 50% of their work time and children in all-day day-care in kindergarten or in the first grade…
Lasten ja nuorten kestävyyskunto
2018
Kestävyyskunto on yksi tutkituimmista terveyteen ja suorituskykyyn yhdistetyistä fyysisen kunnon osa-alueista lapsilla ja nuorilla. Kestävyyskunnon mittaamiseen, sitä koskevien mittaustulosten tulkintaan, kestävyyskunnon harjoitettavuuteen sekä kestävyyskunnon terveysvaikutusten tutkimiseen lapsilla ja nuorilla liittyy yhä haasteita. nonPeerReviewed
The Effects of a 2-year Individualized and Family-based Lifestyle Intervention on Physical Activity, Sedentary Behavior and Diet in Children
2016
Objective To investigate the effects of a long-term, individualized and family-based lifestyle intervention on physical activity, sedentary behavior and diet quality in children. Methods We carried out a 2-year intervention study in a population sample of 506 children aged 6–8 years in Finland in 2007–2012. We allocated the participants at baseline in the intervention and control group. We assessed physical activity and sedentary behavior by questionnaires and diet by food records. Results Total physical activity (+ 9 min/d in intervention group vs. − 5 min/d in control group, p = 0.001 for time*group interaction), unsupervised physical activity (+ 7 min/d vs. − 9 min/d, p < 0.001) and orga…
Longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children
2019
Background: There are few prospective studies on the associations of changes in objectively measured vigorous physical activity (VPA∆), moderate‐to‐vigorous physical activity (MVPA∆), light physical activity (LPA∆), and sedentary time (ST∆) with changes in cardiometabolic risk factors (∆) in children. We therefore investigated these relationships among children. Methods: The participants were a population sample of 258 children aged 6‐8 years followed for 2 years. We assessed PA and ST by a combined heart rate and movement sensor; computed continuous age‐ and sex‐adjusted z‐scores for waist circumference, blood pressure, and fasting insulin, glucose, triglycerides, and high‐density lipoprot…