Search results for " aging."

showing 6 items of 556 documents

Religiosity and social support in Polish older adults: the mediating role of wisdom. Perspectives on Lars Tornstam’s theory of gerotranscendence

2021

Objectives: The purpose of this study was to examine whether wisdom is a mediator in the relation-ships between religious meaning system and social support among older adults. According to the theory of gerotranscendence, associations of religiousness and social support are complex and sug- gest the existence of wisdom in their internal structures. Method: The study included 466 persons aged 50–75. Three measures were used: Religious Meaning System Scale (RMSS), Three-Dimensional Wisdom Scale (3D-WS) and Berlin Social Support Scales (BSSS). Results: The analyses allowed for a partial verification of the hypothesis that wisdom is a mediator in the relationship between the religious meaning s…

theory of gerotranscendenceAdultpositive aginggenetic structureswisdom and old ageSocial SupportReligious meaning systemReligionReligiosityPsychiatry and Mental healthSocial supportAdaptation PsychologicalHumansPositive agingPolandMeaning (existential)Geriatrics and GerontologyPshychiatric Mental HealthPsychologyGerontologySocial psychologyAgedAging & Mental Health
researchProduct

THYROID DISORDERS

2012

thyroid disease aging hyperthyroidism hypothyroidism thyroid nodule non thyroidal illnessmedicine.medical_specialtymedicine.anatomical_structureEndocrinologySettore MED/09 - Medicina Internabusiness.industryInternal medicineThyroidmedicinebusiness
researchProduct

The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.

2021

Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…

transposonsNeocortexMiceHeterochromatinProlyl isomeraseDrosophila ProteinsBiology (General)PhosphorylationRNA Small InterferingTissue homeostasisCells CulturedSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniNeuronsLamin Type BChemistryHP1phosphorylationneurodegenerationnuclear envelopePeptidylprolyl IsomeraseCell biologyDrosophila heterochromatin HP1 Lamin mechanical stress neurodegeneration nuclear envelope phosphorylation PIN1 transposonsNuclear laminaDrosophilaRNA InterferencePremature agingQH301-705.5HeterochromatinNuclear EnvelopeDrosophila; heterochromatin; HP1; Lamin; mechanical stress; neurodegeneration; nuclear envelope; phosphorylation; PIN1; transposonsSettore BIO/11 - Biologia MolecolareSettore MED/08 - Anatomia PatologicaGeneral Biochemistry Genetics and Molecular BiologyPIN1Alzheimer DiseaseSettore MED/05 - Patologia ClinicaAnimalsHumansHeterochromatin maintenancemechanical stressheterochromatinmechanical streMice Inbred C57BLNIMA-Interacting Peptidylprolyl IsomeraseChromobox Protein Homolog 5DNA Transposable ElementsHeterochromatin protein 1Stress MechanicalLaminLaminCell reports
researchProduct

Associations of Sex Hormones and Hormonal Status With Arterial Stiffness in a Female Sample From Reproductive Years to Menopause

2021

ObjectiveLoss of sex hormones has been suggested to underlie menopause-associated increment in cardiovascular risk. We investigated associations of sex hormones with arterial stiffness in 19–58-years-old women. We also studied associations of specific hormonal stages, including natural menstrual cycle, cycle with combined oral contraceptives (COC) and menopausal status with or without hormone therapy (HT), with arterial stiffness.MethodsThis study includes repeated measurements of 65 healthy women representing reproductive (n=16 natural, n=10 COC-users) and menopause (n=5 perimenopausal, n=26 postmenopausal, n=8 HT-users) stages. Arterial stiffness outcomes were aortic pulse wave velocity (…

vascular aginghormonal contraceptionvascular stiffnesspulse wave analysismenstruationRC648-665reproductive hormonesDiseases of the endocrine glands. Clinical endocrinologyFrontiers in Endocrinology
researchProduct

Multifactorial Assessment of Risk of Falling in 753 Post-Menopausal Women: A Multicenter Cross-Sectional Study by the Italian Group for the Study of …

2020

Giovanni Iolascon,1 Alessandro de Sire,1– 3 Dario Calafiore,1,4 Maria Grazia Benedetti,5 Carlo Cisari,2,6 Giulia Letizia Mauro,7 Silvia Migliaccio,8 Ranuccio Nuti,9 Giuseppina Resmini,10 Stefano Gonnelli,9 Antimo Moretti1 1Department of Medical and Surgical Specialties and Dentistry, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Physical and Rehabilitative Medicine, Department of Health Sciences, University of Eastern Piedmont “A. Avogadro”, Novara, Italy; 3Rehabilitation Unit, “Mons L. Novarese” Hospital, Vercelli, Moncrivello, Italy; 4Section of Neuromotor Rehabilitation, Department of Neuroscience, ASST Ca…

walking speed.medicine.medical_specialtyCross-sectional studymedicine.medical_treatmentOsteoporosiswalking speedboneaccidental falls osteoporosis walking speed fractures bone rehabilitationBone remodelingrehabilitationFractures Bone03 medical and health sciences0302 clinical medicineRisk FactorsInternal medicineVitamin D and neurologyHumansMedicineosteoporosi030212 general & internal medicineVitamin DAgedOriginal ResearchAged 80 and overRehabilitationaccidental fallbusiness.industryRC952-954.6General Medicinefracturesmedicine.diseaseosteoporosisPostmenopausePreferred walking speedCross-Sectional StudiesItalyGeriatricsfractureClinical Interventions in AgingCohortrehabilitation.Population studyFemaleaccidental fallsGeriatrics and Gerontologybusiness030217 neurology & neurosurgeryClinical Interventions in Aging
researchProduct

Inspiratory Muscle Strength and Cardiorespiratory Fitness Association With Health-Related Quality of Life in Healthy Older Adults

2021

The main purpose of this study was to explore similarities and differences in the association between two capabilities affecting the cardiorespiratory system (overall and multifactorial cardiorespiratory fitness and inspiratory muscle strength) and the health-related quality of life (HRQoL), in a group of active healthy seniors. Sixty-five individuals (age, 73.01 ± 5.27 years; 53 women) who participated regularly in a multicomponent training program completed the EuroQol 5D-5L questionnaire, the 6-min walking test (6MWT), and the maximum inspiratory pressure test (MIP). Non-parametric correlations (Spearman's rho) were conducted to analyze the association between HRQoL indices (EQindex and …

well-being agingAgingmedicine.medical_specialtymulticomponent exercise programPopulationRespiratory systemlcsh:GV557-1198.99503 medical and health sciencesphysical function0302 clinical medicineQuality of lifeEducación Física y DeportivaMedicine030212 general & internal medicineMaximum Inspiratory Pressure TesteducationAssociation (psychology)Multicomponent exercise programPartial correlationlcsh:SportsHealth related quality of lifeeducation.field_of_studybusiness.industryagingCardiorespiratory fitnessInspiratory muscleBrief Research ReportWell-being agingrespiratory systemhumanitiesSports and Active LivingPhysical functionPhysical therapybusiness030217 neurology & neurosurgeryFrontiers in Sports and Active Living
researchProduct